Evidence map›Paper›PMID 24933483›Full record

ArticleNeuropsychology2014

Life experience and demographic influences on cognitive function in older adults.

Paul W H Brewster, Rebecca J Melrose, María J Marquine, Julene K Johnson, Anna Napoles, Anna MacKay-Brandt, Sarah Farias, Bruce Reed, Dan Mungas

Open access · greenAbstract read
In one paragraph

Article in Neuropsychology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 4 pooled it
11.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 4 syntheses or guidelines pooled it, 118 citations in OpenAlex.

  1. Pooled it
  2. Systematic Review of Pulmonary Function and Cognition in Aging.The journals of gerontology. Series B, Psychological sciences and social sciences · 2020
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Review
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  9. Review
  10. Associations of war-related exposures and early life adversity with late-life cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
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  12. Observational
  13. Observational
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Paul W H BrewsterDepartment of Psychology.
Rebecca J MelroseBrain, Behavior, and Aging Research Center, VA Greater Los Angeles Healthcare System.
María J MarquineDepartment of Psychiatry, University of California.
Julene K JohnsonInstitute for Health & Aging.
Anna NapolesCenter for Aging in Diverse Communities, Department of Medicine, University of California.
Anna MacKay-BrandtDepartment of Outpatient Research, Nathan Kline Institute for Psychiatric Research.
Sarah FariasDepartment of Neurology, School of Medicine.
Bruce ReedDepartment of Neurology, School of Medicine.
Dan MungasDepartment of Neurology, School of Medicine.
University of California, Davis · USUniversity of California, San Francisco · USNathan Kline Institute for Psychiatric Research · USUniversity of California, San Diego · USUniversity of Victoria · CAVA Greater Los Angeles Healthcare System · US

Funding

STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jessica Lynette Montoya · 2001 to 2026
$50.4M
UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3M
RESOURCE CENTER FOR AGING RESEARCH IN DIVERSE POPULATIONP30AG015272 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEAH S KARLINER · 1997 to 2026
$19.5M
FELLOWSHIP IN GERIATRIC MENTAL HEALTHT32MH019934 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Elizabeth W Twamley · 1994 to 2026
$9.5M
Brain pathologies, reserve and cognition in aging and dementiaR01AG031563 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Evan Fletcher, SARAH E TOMASZEWSKI-FARIAS · 2009 to 2026
$8.9M
Research Training in Late-Life NeuroPsychiatric DisordersT32MH020004 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Patrick J Brown · 1998 to 2026
$6.1M
Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN)T32DA031098 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello, DAVID J MOORE · 2011 to 2026
$4.6M
Heterogeneity of Mild Cognitive Impairment(MCI)R01AG021028 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 2003 to 2014
$4.6M
ENGLISH AND SPANISH ASSESSMENT OF COGNITION IN ELDERLYR01AG010220 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI MUNGAS, DAN M. · 1992 to 2012
$4.5M
Community Choirs to Promote Healthy Aging and Independence of Older AdultsR01AG042526 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSON, JULENE K · 2012 to 2016
$3.1M
INVESTIGATOR DEVELOPMENT COREP30AG043097 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HINTON, WALTER LADSON · 2012 to 2017
$2.9M
The Mount Sinai Institute for NeuroAIDS DisparitiesR25MH080663 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MORGELLO, SUSAN · 2007 to 2015
$2.1M
CIHRNIA NIH HHS P30 AG010129NIA NIH HHS P30 AG015272NIA NIH HHS P30 AG043097NIA NIH HHS P30 AG10129NIA NIH HHS P30 AG15272NIA NIH HHS R01 AG010220NIA NIH HHS R01 AG021028NIA NIH HHS R01 AG031252NIA NIH HHS R01 AG031563NIA NIH HHS R01 AG042526NIA NIH HHS R01 AG10220NIA NIH HHS R13 AG030995NIDA NIH HHS T32 DA031098NIMH NIH HHS R25 MH080663NIMH NIH HHS T32 MH019934NIMH NIH HHS T32 MH020004NIMH NIH HHS T32 MH02004
6 · The paper itself

Abstract

objectiveWe examined the influence of a broad spectrum of life experiences on longitudinal cognitive trajectories in a demographically diverse sample of older adults.

methodParticipants were 333 educationally, ethnically, and cognitively diverse older adults enrolled in a longitudinal aging study. Mixed-effects regression was used to measure baseline status in episodic memory, executive functioning, and semantic memory and change in a global cognition factor defined by change in these 3 domain-specific measures. We examined effects of life experience variables (literacy, childhood socioeconomic status, morphometric measures of physical development, life course physical and recreational activity) on longitudinal cognitive trajectories, covarying for age, apolipoprotein E (APOE) genotype and demographics (education, ethnicity, language).

resultsNon-Latino Whites had higher baseline cognition, but life experience variables attenuated ethnic differences in cognitive scores. Age, literacy, childhood socioeconomic status, and physical activity significantly influenced baseline cognition. Age, APOE ε4, and decline in intellectually and socially stimulating recreational activity from mid to late life were independently associated with increased late life cognitive decline. Higher literacy and late life recreational activity were associated with less decline. Literacy had similar effects for English and Spanish readers/speakers. Bilingual English and Spanish speakers did not differ from English Speakers in cognitive performance.

conclusionsLife experience variables, especially literacy level, were strongly related to baseline cognition and substantially attenuated effects of race/ethnicity and education. Cognitive change was best explained by age, APOE ε4, literacy, and current recreational activities. Literacy had robust associations with baseline cognition and cognitive change in both English and Spanish speakers.

Indexed as

CognitionExecutive FunctionLife Change EventsAgedAgingApolipoprotein E4Black or African AmericanCognition DisordersEducational StatusFemaleGenotypeHispanic or LatinoHumansIndividualityLanguageLiteracyApolipoprotein E4

Identifiers

PMID24933483
PMCPMC4227962
OpenAlexW2126398365

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.