ArticlePloS one2014
Expression and functional characterization of NOD2 in decidual stromal cells isolated during the first trimester of pregnancy.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Role and molecular mechanism of NOD2 in chronic non-communicable diseases.Journal of molecular medicine (Berlin, Germany) · 2024Review
- Changes in expression levels of Nod-like receptors in the spleen of ewes.Animal reproduction · 2023Article
- Modulation of Nod-like Receptor Expression in the Thymus during Early Pregnancy in Ewes.Vaccines · 2022Article
- MicroRNA-Mediated Control of Inflammation and Tolerance in Pregnancy.Frontiers in immunology · 2019Review
- Decidual stromal cell-derived PGEAmerican journal of reproductive immunology (New York, N.Y. : 1989) · 2018Article
- Enhanced expression of IFI16 and RIG-I in human third-trimester placentas following HSV-1 infection.Clinical and experimental immunology · 2018Article
- Current concepts in maternal-fetal immunology: Recognition and response to microbial pathogens by decidual stromal cells.American journal of reproductive immunology (New York, N.Y. : 1989) · 2017Review
- Elevated Serum Level of HMGB1 in Patients with the Antiphospholipid Syndrome.Journal of immunology research · 2017Article
- Different expression of NOD2 in decidual stromal cells between normal and unexplained recurrent spontaneous abortion women during first trimester gestation.International journal of clinical and experimental pathology · 2014Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NOD2, one of the cytosolic proteins that contain a nuclear oligomerization domain (NOD), is a pattern recognition receptor (PRR) involved in innate immune responses to intracellular pathogens. Little is known, however, about the effect of NOD2 expression on the maternal-fetal relationship. Our aim was to elucidate the functions of NOD2 in normal decidual stromal cells (DSCs) from the first trimester. Tissues and DSCs were isolated from 26 patients with normal pregnancies that required abortion. The expression of NOD2 in deciduas/decidual stromal cells (DSCs) was examined by real-time PCR, immunohistochemistry, and In-cell western. DSCs containing NOD2 were stimulated by its ligand, muramyl dipeptide (MDP). The secretion of various cytokines and chemokines were measured by ELISA and the apoptotic rate was determined by flow cytometry. Treatment with MDP significantly elevated the expression of both NOD2 mRNA and protein levels in DSCs. In addition, MDP activation of NOD2 significantly increased IL-1β and MCP-1 cytokine expression in a dose dependent manner but had no effect on IL-12 expression. IL-1β and TNF-α also significantly increased the expression of NOD2 in DSCs, suggesting a positive feedback loop mechanism. Moreover, MDP stimulation augmented DSC apoptosis. In summary, the results suggest that NOD2 expression in DSCs plays an important role in protecting the embryo and preventing infection in the maternal-fetal interface.
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