Evidence map›Paper›PMID 24932446›Full record

ReviewMuscles, ligaments and tendons journal2014

Learning about PRP using cell-based models.

Knut Beitzel, Mary Beth McCarthy, Ryan P Russell, John Apostolakos, Mark P Cote, Augustus D Mazzocca

Open access · bronzeAbstract readReview
In one paragraph

Review in Muscles, ligaments and tendons journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Knut BeitzelDepartment of Orthopaedic Sportsmedicine Technical University Munich, Germany.
Mary Beth McCarthyDepartment of Orthopaedic Surgery, UCONN Health Center, Farmington, USA.
Ryan P RussellDepartment of Orthopaedic Surgery, UCONN Health Center, Farmington, USA.
John ApostolakosDepartment of Orthopaedic Surgery, UCONN Health Center, Farmington, USA.
Mark P CoteDepartment of Orthopaedic Surgery, UCONN Health Center, Farmington, USA.
Augustus D MazzoccaDepartment of Orthopaedic Surgery, UCONN Health Center, Farmington, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies using in vitro cell models enable evaluation of the effects of different PRP products under very controlled and standardized conditions. Therefore the results of such studies build the basis for understanding the variable results of clinical studies on the use of PRPs. The main lessons learned through the use of in vitro cell models are that many different PRP products exist and researchers have to report on component variation within each product. These different products may have distinctive effects on the various cells treated in musculoskeletal injuries; therefore, some products might be more beneficial in certain indication than others. In its utilization in cell models, PRP may generate a variety of positive effects on cell proliferation, recovery, and inflammatory response. There might also be a benefit to adding PRP to current pharmacological therapies (e.g. corticosteroids) to prevent their commonly known negative effects on e.g. tendon and cartilage tissue.

Indexed as

in vitroplatelet-rich plasmaPRPtendontenocytes

Identifiers

PMID24932446
PMCPMC4049649
OpenAlexW2017587037

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.