Evidence map›Paper›PMID 24932443›Full record

ArticleMuscles, ligaments and tendons journal2014

Vascular Endothelial Growth Factor-111 (VEGF-111) and tendon healing: preliminary results in a rat model of tendon injury.

Jean-François Kaux, Lauriane Janssen, Pierre Drion, Betty Nusgens, Vincent Libertiaux, Frédéric Pascon, Antoine Heyeres, Audrey Hoffmann, Charles Lambert, Caroline Le Goff and 5 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Muscles, ligaments and tendons journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 51 citations in OpenAlex.

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  13. Modulation of vascular response after injury in the rat Achilles tendon alters healing capacity.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021
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  20. Augmenting endogenous repair of soft tissues with nanofibre scaffolds.Journal of the Royal Society, Interface · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Jean-François KauxPhysical Medicine Service, Department of Motility Sciences, University and University Hospital of Liège, Belgium.
Lauriane JanssenLaboratory of Connective Tissues Biology, GIGA-R, University of Liège, Belgium.
Pierre DrionAnimal Facility of University Hospital of Liège, ULg-GIGA-R, University of Liège, Belgium.
Betty NusgensLaboratory of Connective Tissues Biology, GIGA-R, University of Liège, Belgium.
Vincent LibertiauxDepartment ARGENCO, University of Liège, Belgium.
Frédéric PasconDepartment ARGENCO, University of Liège, Belgium.
Antoine HeyeresLaboratory of Connective Tissues Biology, GIGA-R, University of Liège, Belgium.
Audrey HoffmannLaboratory of Connective Tissues Biology, GIGA-R, University of Liège, Belgium.
Charles LambertLaboratory of Connective Tissues Biology, GIGA-R, University of Liège, Belgium.
Caroline Le GoffDepartment of Clinical Biology, University and University Hospital of Liège, Belgium.
Vincent DenoëlDepartment ARGENCO, University of Liège, Belgium.
Jean-Olivier DefraigneCREDEC, Laboratory of Experimental Surgery, University of Liège, Belgium.
Markus RickertDepartment of Orthopaedic Surgery, University of Giessen, Germany.
Jean-Michel CrielaardPhysical Medicine Service, Department of Motility Sciences, University and University Hospital of Liège, Belgium.
Alain ColigeAnimal Facility of University Hospital of Liège, ULg-GIGA-R, University of Liège, Belgium.
University of Liège · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tendon lesions are among the most frequent musculoskeletal pathologies. Vascular endothelial growth factor (VEGF) is known to regulate angiogenesis. VEGF-111, a biologically active and proteolysis-resistant splice variant of this family, was recently identified. This study aimed at evaluating whether VEGF-111 could have a therapeutic interest in tendon pathologies. Surgical section of one Achilles tendon of rats was performed before a local injection of either saline or VEGF-111. After 5, 15 and 30 days, the Achilles tendons of 10 rats of both groups were sampled and submitted to a biomechanical tensile test. The force necessary to induce tendon rupture was greater for tendons of the VEGF-111 group (p<0.05) while the section areas of the tendons were similar. The mechanical stress was similar at 5 and 15 days in the both groups but was improved for the VEGF-111 group at day 30 (p <0.001). No difference was observed in the mRNA expression of collagen III, tenomodulin and MMP-9. In conclusion, we observed that a local injection of VEGF-111 improves the early phases of the healing process of rat tendons after a surgical section. Further confirmatory experimentations are needed to consolidate our results.

Indexed as

biomechanicalgrowth factorhealingtendonVEGFVEGF-111

Identifiers

PMID24932443
PMCPMC4049645
OpenAlexW2104317066

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.