Evidence map›Paper›PMID 24932428›Full record

ArticleFatigue : biomedicine, health & behavior2014

Chronic Fatigue Syndrome: The Current Status and Future Potentials of Emerging Biomarkers.

David Benjamin Fischer, Arsani Hany William, Adam Campbell Strauss, Elizabeth R Unger, Leonard Jason, Gailen D Marshall, Jordan D Dimitrakoff

Abstract read
In one paragraph

Article in Fatigue : biomedicine, health & behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David Benjamin FischerHarvard Medical School, 25 Shattuck Street, Boston, MA, USA 02115.
Arsani Hany WilliamHarvard Medical School, 25 Shattuck Street, Boston, MA, USA 02115.
Adam Campbell StraussHarvard Medical School, 25 Shattuck Street, Boston, MA, USA 02115 ; Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03766.
Elizabeth R UngerCenters for Disease Control and Prevention, Atlanta, GA 30333.
Leonard JasonDePaul University, Chicago, IL.
Gailen D MarshallUniversity of Mississippi Medical Center, Jackson, MS.
Jordan D DimitrakoffHarvard Medical School, 25 Shattuck Street, Boston, MA, USA 02115 ; Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 ; Johns Hopkins University School of Medicine, Baltimore, MD.

Funding

A prospective study of CFS following infectious mononucleosis in college studentsR01AI105781 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI JASON, LEONARD A, KATZ, BEN Z. · 2014 to 2018
$3.4M
Pediatric CFS in a Community-Based SampleR01HD072208 · NICHD · DE PAUL UNIVERSITY · PI JASON, LEONARD A · 2013 to 2017
$2.0M
NIAID NIH HHS R01 AI105781NICHD NIH HHS R01 HD072208
6 · The paper itself

Abstract

Chronic fatigue syndrome (CFS) remains an incompletely characterized illness, in part due to controversy regarding its definition, biological basis and diagnosis. Biomarkers are objective measures that may lead to improvements in our understanding of CFS by providing a more coherent and consistent approach to study, diagnosis and treatment of the illness. Such metrics may allow us to distinguish between CFS subtypes - each defined by characteristic biomarkers - currently conflated under the single, heterogeneous condition of CFS. These delineations, in turn, may guide more granular, focused, and targeted treatment strategies based on more precise characterizations of the illness. Here, we review potential CFS biomarkers related to neurological and immunological components of the illness, and discuss how these biomarkers may be used to move the field of CFS forward, emphasizing clinical utility and potential routes of future research.

Identifiers

PMID24932428
PMCPMC4052724

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.