Evidence map›Paper›PMID 24932303›Full record

ArticleOncology letters2014

The role of MALAT1 correlates with HPV in cervical cancer.

Yan Jiang, Yuehui Li, Shujuan Fang, Binyuan Jiang, Changfei Qin, Pingli Xie, Guohua Zhou, Guancheng Li

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 115 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yan JiangCancer Research Institution, Xiangya Medical School, Central South University, Changsha, Hunan 410078, P.R. China.
Yuehui LiCancer Research Institution, Xiangya Medical School, Central South University, Changsha, Hunan 410078, P.R. China.
Shujuan FangCancer Research Institution, Xiangya Medical School, Central South University, Changsha, Hunan 410078, P.R. China.
Binyuan JiangCancer Research Institution, Xiangya Medical School, Central South University, Changsha, Hunan 410078, P.R. China.
Changfei QinCancer Research Institution, Xiangya Medical School, Central South University, Changsha, Hunan 410078, P.R. China.
Pingli XieCancer Research Institution, Xiangya Medical School, Central South University, Changsha, Hunan 410078, P.R. China.
Guohua ZhouCancer Research Institution, Xiangya Medical School, Central South University, Changsha, Hunan 410078, P.R. China.
Guancheng LiCancer Research Institution, Xiangya Medical School, Central South University, Changsha, Hunan 410078, P.R. China.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cervical cancer, the second most common type of cancer in women worldwide, is responsible for >275,100 mortalities each year and is associated with high-risk human papilloma virus (HR-HPV). HPVs have two important oncogenes, E6 and E7, which have crucial roles in malignant transformation in cervical cancer. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-coding RNA originally identified in non-small cell lung cancer. Previous studies have revealed that MALAT1 is expressed in numerous tissue types, and is significant in maintaining the normal function of the body. However, it also appeared to be notably upregulated in numerous carcinoma types compared with adjacent non-cancerous tissues. In the present study, it was identified that MALAT1 expression was upregulated in cervical cancer cell lines compared with normal cervical squamous cell samples. Further study into the effect of MALAT1 on cellular phenotype revealed that MALAT1 was able to promote cell migration and proliferation. Of note, it was revealed that the expression of MALAT1 was decreased with the knockdown of HPV16 E6/E7 in CaSki cells. Furthermore, the investigations in clinical samples also revealed that MALAT1 was expressed in HPV-positive cervical squamous cells, but not in HPV-negative normal cervical squamous cells. These results indicate that HPV correlates with MALAT1 deregulation in cervical cancer.

Indexed as

cell proliferationcervical cancerhuman papilloma virusmetastasis-associated lung adenocarcinoma transcript 1

Identifiers

PMID24932303
PMCPMC4049771
OpenAlexW2071504371

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.