ArticleDental research journal2014
Evaluation of the efficacy of taurine as an antioxidant in the management of patients with chronic periodontitis.
Article in Dental research journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- The assessment of glutathione, glutathione peroxidase, glutathione reductase, and oxidized glutathione in patients with periodontitis-A systematic review and meta-analysis.Clinical and experimental dental research · 2024Pooled it
- Taurine, Sirtuin-1 and TNF- α levels in different aged adults with periodontitis: a pilot study.BMC oral health · 2025Trial
- Antibacterial, antibiofilm, and antiproliferative properties of Aspergillus frequens-derived pigment.Microbial cell factories · 2025Article
- Salivary metabolites associated with a 5-year tooth loss identified in a population-based setting.BMC medicine · 2021Article
- Salivary Metabolomics: From Diagnostic Biomarker Discovery to Investigating Biological Function.Metabolites · 2020Review
- Oxidative Stress and Antioxidants in the Diagnosis and Therapy of Periodontitis.Frontiers in physiology · 2017Review
- Oxidative Stress and Antioxidant System in Periodontitis.Frontiers in physiology · 2017Review
- Hydrogen Sulfide, Oxidative Stress and Periodontal Diseases: A Concise Review.Antioxidants (Basel, Switzerland) · 2016Review
- Taurine Regulates Mitochondrial Function During 7,12-Dimethyl Benz[a]anthracene Induced Experimental Mammary Carcinogenesis.Journal of pharmacopuncture · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn the recent years, various studies have shown a link between the free radicals, antioxidants and periodontal diseases. The purpose of the present study was to evaluate the oxidative stress and the antioxidant status present in the gingival tissue and plasma of patients with chronic periodontitis and to evaluate the antioxidant property of taurine. MATERIALS AND
methodsPeriodontal status in 10 chronic periodontitis patients was assessed in terms of gingival index, plaque index, probing pocket depth and clinical attachment level prior to and after oral administration of taurine (500 mg O.D.) for 15 days. The oxidative stress present in the gingival tissue and blood (by measuring thiobarbituric acid reactive substance [TBARS]) and the antioxidants namely glutathione peroxidase (GPX) and reduced glutathione (GSH) were estimated before and after administration of taurine. The changes in the clinical parameters were also reassessed following administration of taurine. Statistical comparisons were performed using the Student's t-test. A level of P < 0.05 was considered as statistically significant.
resultsThe levels of TBARS in plasma and gingival tissue showed a significant reduction (P < 0.001) following administration of taurine. The antioxidant enzyme GPX showed a significant reduction following administration of taurine (P < 0.001), whereas GSH increased significantly (P < 0.001) following administration of taurine. The improvement in the periodontal status following administration of taurine was also significant statistically.
conclusionBased on the biochemical and clinical assessments, taurine seems to exert a protective role against the oxidative stress in the management of patients with chronic periodontitis.
Indexed as
Identifiers
24932194PMC4052649W1549143863What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.