Evidence map›Paper›PMID 24932109›Full record

ArticleJournal of central nervous system disease2014

Neuronal and glia-related biomarkers in cerebrospinal fluid of patients with acute ischemic stroke.

Clara Hjalmarsson, Maria Bjerke, Björn Andersson, Kaj Blennow, Henrik Zetterberg, N David Aberg, Bob Olsson, Carl Eckerström, Lena Bokemark, Anders Wallin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of central nervous system disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.

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  20. Liquid biopsy markers for stroke diagnosis.Expert review of molecular diagnostics · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Clara HjalmarssonThe Stroke Unit, Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
Maria BjerkeInstitute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, University of Gothenburg, The Sahlgrenska Academy, Gothenburg, Sweden.
Björn AnderssonThe Stroke Unit, Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
Kaj BlennowInstitute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, University of Gothenburg, The Sahlgrenska Academy, Gothenburg, Sweden.
Henrik ZetterbergInstitute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, University of Gothenburg, The Sahlgrenska Academy, Gothenburg, Sweden. ; UCL Institute of Neurology, Queen Square, London, UK.
N David AbergThe Stroke Unit, Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
Bob OlssonInstitute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, University of Gothenburg, The Sahlgrenska Academy, Gothenburg, Sweden.
Carl EckerströmInstitute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, University of Gothenburg, The Sahlgrenska Academy, Gothenburg, Sweden.
Lena BokemarkThe Stroke Unit, Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
Anders WallinInstitute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, University of Gothenburg, The Sahlgrenska Academy, Gothenburg, Sweden.
University College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCerebral ischemia promotes morphological reactions of the neurons, astrocytes, oligodendrocytes, and microglia in experimental studies. Our aim was to examine the profile of CSF (cerebrospinal fluid) biomarkers and their relation to stroke severity and degree of white matter lesions (WML).

methodsA total of 20 patients (mean age 76 years) were included within 5-10 days after acute ischemic stroke (AIS) onset. Stroke severity was assessed using NIHSS (National Institute of Health stroke scale). The age-related white matter changes (ARWMC) scale was used to evaluate the extent of WML on CT-scans. The concentrations of specific CSF biomarkers were analyzed.

resultsPatients with AIS had significantly higher levels of NFL (neurofilament, light), T-tau, myelin basic protein (MBP), YKL-40, and glial fibrillary acidic protein (GFAP) compared with controls; T-Tau, MBP, GFAP, and YKL-40 correlated with clinical stroke severity, whereas NFL correlated with severity of WML (tested by Mann-Whitney test).

conclusionsSeveral CSF biomarkers increase in AIS, and they correlate to clinical stroke severity. However, only NFL was found to be a marker of degree of WML.

Indexed as

cerebrospinal fluidneurodegenerationstrokeWML

Identifiers

PMID24932109
PMCPMC4039292
OpenAlexW1998025612

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.