ArticleThe Journal of rheumatology2014
The diagnostic performance of anterior knee pain and activity-related pain in identifying knees with structural damage in the patellofemoral joint: the Multicenter Osteoarthritis Study.
Open access · bronzeAbstract readMulticenter Study
In one paragraph
Article in The Journal of rheumatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Comparative efficacy of high intensity laser therapy (Class IV) and ibuprofen gel phonophoresis in the treatment of knee osteoarthritis among people living in hilly terrain: A randomized controlled study.Lasers in medical science · 2025Trial
- A questionnaire to identify patellofemoral pain in the community: an exploration of measurement properties.BMC musculoskeletal disorders · 2016Trial
- Associations between anterior knee pain and 2-year patellofemoral cartilage worsening: The MOST study.Osteoarthritis and cartilage · 2024Article
- Mapping the course to recovery: a prospective study on the anatomic distribution of early postoperative pain after total knee arthroplasty.Arthroplasty (London, England) · 2023Article
- Magnetic Resonance Imaging-Defined Osteoarthritis Features and Anterior Knee Pain in Individuals With, or at Risk for, Knee Osteoarthritis: A Multicenter Study on Osteoarthritis.Arthritis care & research · 2022Article
- Preoperative muscle thickness influences muscle activation after arthroscopic knee surgery.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022Article
- Pain descriptors and determinants of pain sensitivity in knee osteoarthritis: a community-based cross-sectional study.Rheumatology advances in practice · 2022Article
- Patellofemoral Pain After Arthroscopy: Muscle Atrophy Is Not Everything.Orthopaedic journal of sports medicine · 2021Article
- A New Procedure for Ultrasound-Guided Hydrorelease for the Scarring After Arthroscopic Knee Surgery.Cureus · 2020Article
- Physical Therapist Management of Anterior Knee Pain.Current reviews in musculoskeletal medicine · 2020Review
- Psychological and Pain Sensitization Characteristics Are Associated With Patellofemoral Osteoarthritis Symptoms: The Multicenter Osteoarthritis Study.The Journal of rheumatology · 2020Article
- A New Clustering Method for Knee Movement Impairments using Partitioning Around Medoids Model.Iranian journal of medical sciences · 2020Article
- Medical Interventions for Patellofemoral Pain and Patellofemoral Osteoarthritis: A Systematic Review.Journal of clinical medicine · 2020Article
- Article
- Pressure algometry is a suitable tool to assess anterior knee pain in osteoarthritic patients.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2019Article
- Brief Report: Leg Length Inequality and Hip Osteoarthritis in the Multicenter Osteoarthritis Study and the Osteoarthritis Initiative.Arthritis & rheumatology (Hoboken, N.J.) · 2018Article
- Patellofemoral morphology and alignment: reference values and dose-response patterns for the relation to MRI features of patellofemoral osteoarthritis.Osteoarthritis and cartilage · 2017Article
- Severity and distribution of cartilage damage and bone marrow edema in the patellofemoral and tibiofemoral joints in knee osteoarthritis determined by MRI.Experimental and therapeutic medicine · 2017Article
- Changes in clinical symptoms and functional disability in patients with coexisting patellofemoral and tibiofemoral osteoarthritis: a 1-year prospective cohort study.BMC musculoskeletal disorders · 2017Article
- Is There a Biomechanical Link Between Patellofemoral Pain and Osteoarthritis? A Narrative Review.Sports medicine (Auckland, N.Z.) · 2016Review
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 3 countries.
Joshua J StefanikFrom Boston University, Boston, Massachusetts; the University of California, San Francisco, California; the University of Alabama, Birmingham, Alabama; the University of Iowa, Iowa City, Iowa, USA; Klinikum Augsburg, Augsburg, Germany.J.J. Stefanik, MSPT, PhD, Research Assistant Professor of Physical Therapy and Athletic Training; T. Neogi, MD, PhD, Associate Professor of Medicine; J. Niu, DSc, Clinical Epidemiology and Research Training Unit; A. Guermazi, MD, PhD, Professor of Radiology; D.T. Felson, MD, MPH, Professor of Medicine, Boston University; F.W. Roemer, MD, Associate Professor, Klinikum Augsburg; M.C. Nevitt, PhD, Professor of Epidemiology and Biostatistics, University of California, San Francisco; C.E. Lewis, MD, Professor of Medicine, University of Alabama; N.A. Segal, MD, Associate Professor of Orthopedics and Rehabilitation, University of Iowa. stefanik@bu.edu.
Tuhina NeogiFrom Boston University, Boston, Massachusetts; the University of California, San Francisco, California; the University of Alabama, Birmingham, Alabama; the University of Iowa, Iowa City, Iowa, USA; Klinikum Augsburg, Augsburg, Germany.J.J. Stefanik, MSPT, PhD, Research Assistant Professor of Physical Therapy and Athletic Training; T. Neogi, MD, PhD, Associate Professor of Medicine; J. Niu, DSc, Clinical Epidemiology and Research Training Unit; A. Guermazi, MD, PhD, Professor of Radiology; D.T. Felson, MD, MPH, Professor of Medicine, Boston University; F.W. Roemer, MD, Associate Professor, Klinikum Augsburg; M.C. Nevitt, PhD, Professor of Epidemiology and Biostatistics, University of California, San Francisco; C.E. Lewis, MD, Professor of Medicine, University of Alabama; N.A. Segal, MD, Associate Professor of Orthopedics and Rehabilitation, University of Iowa.
Jingbo NiuFrom Boston University, Boston, Massachusetts; the University of California, San Francisco, California; the University of Alabama, Birmingham, Alabama; the University of Iowa, Iowa City, Iowa, USA; Klinikum Augsburg, Augsburg, Germany.J.J. Stefanik, MSPT, PhD, Research Assistant Professor of Physical Therapy and Athletic Training; T. Neogi, MD, PhD, Associate Professor of Medicine; J. Niu, DSc, Clinical Epidemiology and Research Training Unit; A. Guermazi, MD, PhD, Professor of Radiology; D.T. Felson, MD, MPH, Professor of Medicine, Boston University; F.W. Roemer, MD, Associate Professor, Klinikum Augsburg; M.C. Nevitt, PhD, Professor of Epidemiology and Biostatistics, University of California, San Francisco; C.E. Lewis, MD, Professor of Medicine, University of Alabama; N.A. Segal, MD, Associate Professor of Orthopedics and Rehabilitation, University of Iowa.
Frank W RoemerFrom Boston University, Boston, Massachusetts; the University of California, San Francisco, California; the University of Alabama, Birmingham, Alabama; the University of Iowa, Iowa City, Iowa, USA; Klinikum Augsburg, Augsburg, Germany.J.J. Stefanik, MSPT, PhD, Research Assistant Professor of Physical Therapy and Athletic Training; T. Neogi, MD, PhD, Associate Professor of Medicine; J. Niu, DSc, Clinical Epidemiology and Research Training Unit; A. Guermazi, MD, PhD, Professor of Radiology; D.T. Felson, MD, MPH, Professor of Medicine, Boston University; F.W. Roemer, MD, Associate Professor, Klinikum Augsburg; M.C. Nevitt, PhD, Professor of Epidemiology and Biostatistics, University of California, San Francisco; C.E. Lewis, MD, Professor of Medicine, University of Alabama; N.A. Segal, MD, Associate Professor of Orthopedics and Rehabilitation, University of Iowa.
Neil A SegalFrom Boston University, Boston, Massachusetts; the University of California, San Francisco, California; the University of Alabama, Birmingham, Alabama; the University of Iowa, Iowa City, Iowa, USA; Klinikum Augsburg, Augsburg, Germany.J.J. Stefanik, MSPT, PhD, Research Assistant Professor of Physical Therapy and Athletic Training; T. Neogi, MD, PhD, Associate Professor of Medicine; J. Niu, DSc, Clinical Epidemiology and Research Training Unit; A. Guermazi, MD, PhD, Professor of Radiology; D.T. Felson, MD, MPH, Professor of Medicine, Boston University; F.W. Roemer, MD, Associate Professor, Klinikum Augsburg; M.C. Nevitt, PhD, Professor of Epidemiology and Biostatistics, University of California, San Francisco; C.E. Lewis, MD, Professor of Medicine, University of Alabama; N.A. Segal, MD, Associate Professor of Orthopedics and Rehabilitation, University of Iowa.
Cora E LewisFrom Boston University, Boston, Massachusetts; the University of California, San Francisco, California; the University of Alabama, Birmingham, Alabama; the University of Iowa, Iowa City, Iowa, USA; Klinikum Augsburg, Augsburg, Germany.J.J. Stefanik, MSPT, PhD, Research Assistant Professor of Physical Therapy and Athletic Training; T. Neogi, MD, PhD, Associate Professor of Medicine; J. Niu, DSc, Clinical Epidemiology and Research Training Unit; A. Guermazi, MD, PhD, Professor of Radiology; D.T. Felson, MD, MPH, Professor of Medicine, Boston University; F.W. Roemer, MD, Associate Professor, Klinikum Augsburg; M.C. Nevitt, PhD, Professor of Epidemiology and Biostatistics, University of California, San Francisco; C.E. Lewis, MD, Professor of Medicine, University of Alabama; N.A. Segal, MD, Associate Professor of Orthopedics and Rehabilitation, University of Iowa.
Michael NevittFrom Boston University, Boston, Massachusetts; the University of California, San Francisco, California; the University of Alabama, Birmingham, Alabama; the University of Iowa, Iowa City, Iowa, USA; Klinikum Augsburg, Augsburg, Germany.J.J. Stefanik, MSPT, PhD, Research Assistant Professor of Physical Therapy and Athletic Training; T. Neogi, MD, PhD, Associate Professor of Medicine; J. Niu, DSc, Clinical Epidemiology and Research Training Unit; A. Guermazi, MD, PhD, Professor of Radiology; D.T. Felson, MD, MPH, Professor of Medicine, Boston University; F.W. Roemer, MD, Associate Professor, Klinikum Augsburg; M.C. Nevitt, PhD, Professor of Epidemiology and Biostatistics, University of California, San Francisco; C.E. Lewis, MD, Professor of Medicine, University of Alabama; N.A. Segal, MD, Associate Professor of Orthopedics and Rehabilitation, University of Iowa.
Ali GuermaziFrom Boston University, Boston, Massachusetts; the University of California, San Francisco, California; the University of Alabama, Birmingham, Alabama; the University of Iowa, Iowa City, Iowa, USA; Klinikum Augsburg, Augsburg, Germany.J.J. Stefanik, MSPT, PhD, Research Assistant Professor of Physical Therapy and Athletic Training; T. Neogi, MD, PhD, Associate Professor of Medicine; J. Niu, DSc, Clinical Epidemiology and Research Training Unit; A. Guermazi, MD, PhD, Professor of Radiology; D.T. Felson, MD, MPH, Professor of Medicine, Boston University; F.W. Roemer, MD, Associate Professor, Klinikum Augsburg; M.C. Nevitt, PhD, Professor of Epidemiology and Biostatistics, University of California, San Francisco; C.E. Lewis, MD, Professor of Medicine, University of Alabama; N.A. Segal, MD, Associate Professor of Orthopedics and Rehabilitation, University of Iowa.
David T FelsonFrom Boston University, Boston, Massachusetts; the University of California, San Francisco, California; the University of Alabama, Birmingham, Alabama; the University of Iowa, Iowa City, Iowa, USA; Klinikum Augsburg, Augsburg, Germany.J.J. Stefanik, MSPT, PhD, Research Assistant Professor of Physical Therapy and Athletic Training; T. Neogi, MD, PhD, Associate Professor of Medicine; J. Niu, DSc, Clinical Epidemiology and Research Training Unit; A. Guermazi, MD, PhD, Professor of Radiology; D.T. Felson, MD, MPH, Professor of Medicine, Boston University; F.W. Roemer, MD, Associate Professor, Klinikum Augsburg; M.C. Nevitt, PhD, Professor of Epidemiology and Biostatistics, University of California, San Francisco; C.E. Lewis, MD, Professor of Medicine, University of Alabama; N.A. Segal, MD, Associate Professor of Orthopedics and Rehabilitation, University of Iowa.
Boston University · USBiomedical Research and Training Institute · ZWMoog (United States) · USUniversity of Alabama at Birmingham · USUniversity of California, San Francisco · USUniversity of Iowa · USYazd University · IR
Funding
Multicenter Osteoarthritis Study (MOST) Second RenewalU01AG019069 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NEVITT, MICHAEL C · 2001 to 2020
$21.7MUniversity of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Stuart J Frank · 2013 to 2026
$19.5MWORK DISABILITY-- PERSONS WITH RHEUMATOID ARTHRITISP60AR047785 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FELSON, DAVID TOBIN · 2001 to 2016
$18.0MMulticenter Osteoarthritis Study (MOST) Second Renewal: Iowa Clinical CenterU01AG018832 · NIA · UNIVERSITY OF IOWA · PI SEGAL, NEIL A, TORNER, JAMES C · 2001 to 2020
$14.1MMulticenter Osteoarthritis Study (MOST) Second Renewal - Boston UniversityU01AG018820 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FELSON, DAVID TOBIN · 2001 to 2019
$13.6MMulticenter Osteoarthritis Study (MOST) Second Renewal - UAB Clinical CenterU01AG018947 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEWIS, CORA E · 2001 to 2020
$13.2MNIAMS NIH HHS AR-47785NIAMS NIH HHS P60 AR047785NIA NIH HHS U01 AG018820NIA NIH HHS U01 AG018832NIA NIH HHS U01 AG018947NIA NIH HHS U01 AG019069NIA NIH HHS U01-AG18820NIA NIH HHS U01-AG18832NIA NIH HHS U01-AG18947NIA NIH HHS U01-AG19069NIDDK NIH HHS P30 DK079626
Abstract
objectiveTo determine the diagnostic test performance of location of pain and activity-related pain in identifying knees with patellofemoral joint (PFJ) structural damage.
methodsThe Multicenter Osteoarthritis Study is a US National Institutes of Health-funded cohort study of older adults with or at risk of knee osteoarthritis. Subjects identified painful areas around the knee on a knee pain map and the Western Ontario and McMaster Universities Osteoarthritis Index was used to assess pain with stairs and walking on level ground. Cartilage damage and bone marrow lesions were assessed from knee magnetic resonance imaging. We determined the sensitivity, specificity, positive and negative predictive values for presence of anterior knee pain (AKP), pain with stairs, absence of pain while walking on level ground, and combinations of tests in discriminating knees with isolated PFJ structural damage from those with isolated tibiofemoral joint (TFJ) or no structural damage. Knees with mixed PFJ/TFJ damage were removed from our analyses because of the inability to determine which compartment was causing pain.
resultsThere were 407 knees that met our inclusion criteria. "Any" AKP had a sensitivity of 60% and specificity of 53%; and if AKP was the only area of pain, the sensitivity dropped to 27% but specificity rose to 81%. Absence of moderate pain with walking on level ground had the greatest sensitivity (93%) but poor specificity (13%). The combination of "isolated" AKP and moderate pain with stairs had poor sensitivity (9%) but the greatest specificity (97%) of strategies tested.
conclusionCommonly used questions purported to identify knees with PFJ structural damage do not identify this condition with great accuracy.
Indexed as
AgedAged, 80 and overArthralgiaCohort StudiesFemaleHumansKnee JointMagnetic Resonance ImagingMaleMiddle AgedOsteoarthritis, KneePain MeasurementPatellofemoral JointProspective StudiesRisk FactorsSelf ReportMAGNETIC RESONANCE IMAGINGOSTEOARTHRITISPAIN
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