Evidence map›Paper›PMID 24931841›Full record

ArticleBlood transfusion = Trasfusione del sangue2014

Patient blood management in orthopaedic surgery: a four-year follow-up of transfusion requirements and blood loss from 2008 to 2011 at the Balgrist University Hospital in Zurich, Switzerland.

Oliver M Theusinger, Stephanie L Kind, Burkhardt Seifert, Lain Borgeat, Christian Gerber, Donat R Spahn

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood transfusion = Trasfusione del sangue, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04777097 (Does Preeclampsia Affect Blood Loss During a Caesarean Procedure), which is not on this map. Cited by 42 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04777097 unknown statusnot on this mapstarted 2021, after this paper: background citation

Does Preeclampsia Affect Blood Loss During a Caesarean Procedure

TypeobservationalSponsorUniversity of ZurichRan2021 to 2025Enrolled120ConditionsPre-Eclampsia, Complicating Pregnancy, Blood Loss, Coagulation DisorderArmsBlood sample
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 109 citations in OpenAlex.

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  13. Perioperative protocol to reduce blood transfusions in total knee o hip replacement patientsRevista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Oliver M TheusingerInstitute of Anaesthesiology, University and University Hospital Zurich, Balgrist Hospital, Zurich, Switzerland.
Stephanie L KindInstitute of Anaesthesiology, University and University Hospital Zurich, Balgrist Hospital, Zurich, Switzerland.
Burkhardt SeifertDivision of Biostatistics, Institute of Social and Preventive Medicine, University of Zurich, Balgrist Hospital, Zurich, Switzerland.
Lain BorgeatDepartment of Orthopaedics, University of Zurich, Balgrist Hospital, Zurich, Switzerland.
Christian GerberDepartment of Orthopaedics, University of Zurich, Balgrist Hospital, Zurich, Switzerland.
Donat R SpahnInstitute of Anaesthesiology, University and University Hospital Zurich, Balgrist Hospital, Zurich, Switzerland.
Universitätsklinik Balgrist · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to investigate the impact of the introduction of a Patient Blood Management (PBM) programme in elective orthopaedic surgery on immediate pre-operative anaemia, red blood cell (RBC) mass loss, and transfusion. MATERIALS AND

methodsOrthopaedic operations (hip, n=3,062; knee, n=2,953; and spine, n=2,856) performed between 2008 and 2011 were analysed. Period 1 (2008), was before the introduction of the PBM programme and period 2 (2009 to 2011) the time after its introduction. Immediate pre-operative anaemia, RBC mass loss, and transfusion rates in the two periods were compared.

resultsIn hip surgery, the percentage of patients with immediate pre-operative anaemia decreased from 17.6% to 12.9% (p<0.001) and RBC mass loss was unchanged, being 626±434 vs 635±450 mL (p=0.974). Transfusion rate was significantly reduced from 21.8% to 15.7% (p<0.001). The number of RBC units transfused remained unchanged (p=0.761). In knee surgery the prevalence of immediate pre-operative anaemia decreased from 15.5% to 7.8% (p<0.001) and RBC mass loss reduced from 573±355 to 476±365 mL (p<0.001). The transfusion rate dropped from 19.3% to 4.9% (p<0.001). RBC transfusions decreased from 0.53±1.27 to 0.16±0.90 units (p<0.001). In spine surgery the prevalence of immediate pre-operative anaemia remained unchanged (p=0.113), RBC mass loss dropped from 551±421 to 404±337 mL (p<0.001), the transfusion rate was reduced from 18.6 to 8.6% (p<0.001) and RBC transfusions decreased from 0.66±1.80 to 0.22±0.89 units (p=0.008). DISCUSSION: Detection and treatment of pre-operative anaemia, meticulous surgical technique, optimal surgical blood-saving techniques, and standardised transfusion triggers in the context of PBM programme resulted in a lower incidence of immediate pre-operative anaemia, reduction in RBC mass loss, and a lower transfusion rate.

Indexed as

Orthopedic ProceduresAdultAgedAnemiaBlood Loss, SurgicalErythrocyte TransfusionFemaleFollow-Up StudiesHospitals, UniversityHumansMaleMiddle AgedRetrospective StudiesSwitzerland

Identifiers

PMID24931841
PMCPMC4039701
OpenAlexW1688601832

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.