ArticleNeurobiology of learning and memory2014
Localization of the cerebellar cortical zone mediating acquisition of eyeblink conditioning in rats.
Article in Neurobiology of learning and memory, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Three principles for the utility of simple tasks that assess elemental processes in parsing heterogeneity.Journal of psychopathology and clinical science · 2024Article
- Knockdown of the Non-canonical Wnt Gene Prickle2 Leads to Cerebellar Purkinje Cell Abnormalities While Cerebellar-Mediated Behaviors Remain Intact.Cerebellum (London, England) · 2024Article
- Climbing fibers provide essential instructive signals for associative learning.Nature neuroscience · 2024Article
- Synaptic mechanisms for associative learning in the cerebellar nuclei.Nature communications · 2023Article
- Reexposure to a sensorimotor perturbation produces opposite effects on explicit and implicit learning processes.PLoS biology · 2021Article
- Young Domestic PigsFrontiers in behavioral neuroscience · 2021Article
- A FN-MdV pathway and its role in cerebellar multimodular control of sensorimotor behavior.Nature communications · 2020Article
- Bidirectional short-term plasticity during single-trial learning of cerebellar-driven eyelid movements in mice.Neurobiology of learning and memory · 2020Article
- Cannabinoid agonist administration within the cerebellar cortex impairs motor learning.Neurobiology of learning and memory · 2020Review
- Intrinsic Excitability Increase in Cerebellar Purkinje Cells after Delay Eye-Blink Conditioning in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Intracerebellar cannabinoid administration impairs delay but not trace eyeblink conditioning.Behavioural brain research · 2020Article
- Impact of parallel fiber to Purkinje cell long-term depression is unmasked in absence of inhibitory input.Science advances · 2018Article
- Locomotor activity modulates associative learning in mouse cerebellum.Nature neuroscience · 2018Article
- Cannabinoid modulation of memory consolidation within the cerebellum.Neurobiology of learning and memory · 2016Article
- Amygdala Modulation of Cerebellar Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Cerebellar Premotor Output Neurons Collateralize to Innervate the Cerebellar Cortex.The Journal of comparative neurology · 2015Article
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2 authors.
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Abstract
Delay eyeblink conditioning is established by paired presentations of a conditioned stimulus (CS) such as a tone or light and an unconditioned stimulus (US) that elicits eyelid closure before training. The CS and US inputs converge on Purkinje cells in the cerebellar cortex. The cerebellar cortex plays a substantial role in acquisition of delay eyeblink conditioning in rabbits and rodents, but the specific area of the cortex that is necessary for acquisition in rodents has not been identified. A recent study identified an eyeblink microzone in the mouse cerebellar cortex at the base of the primary fissure (Heiney, Kim, Augustine, & Medina, 2014). There is no evidence that the cortex in this eyeblink microzone plays a role in rodent eyeblink conditioning but it is a good candidate region. Experiment 1 examined the effects of unilateral (ipsilateral to the US) lesions of lobule HVI, the lateral anterior lobe, or the base of the primary fissure on eyeblink conditioning in rats. Lesions of either the anterior lobe or lobule HVI impaired acquisition, but lesions of the base of the primary fissure produced the largest deficit. Experiment 2 used reversible inactivation with muscimol to demonstrate that inactivation of the putative eyeblink microzone severely impaired acquisition and had only a modest effect on retention of eyeblink conditioning. The findings indicate that the base of the primary fissure is the critical zone of the cerebellar cortex for acquisition of eyeblink conditioning in rats.
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