Evidence map›Paper›PMID 24931767›Full record

ArticleBrain research2014

Brain CD47 expression in a swine model of intracerebral hemorrhage.

Xiang Zhou, Qing Xie, Guohua Xi, Richard F Keep, Ya Hua

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xiang ZhouDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Qing XieDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Guohua XiDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Richard F KeepDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Ya HuaDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA. Electronic address: yahua@umich.edu.
University of Michigan–Ann Arbor · US

Funding

Mechanisms of Brain Injury after Intraventricular HemorrhageR01NS073595 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XI, GUOHUA · 2012 to 2016
$1.7M
Mechanisms of early brain injury after subarachnoid hemmorrhageR01NS079157 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XI, GUOHUA · 2012 to 2016
$1.7M
CD47 and hematoma clearance in intracerebral hemorrhageR21NS084049 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUA, YA · 2013 to 2014
$425k
NINDS NIH HHS NS-073595NINDS NIH HHS NS-079157NINDS NIH HHS NS-084049NINDS NIH HHS R01 NS073595NINDS NIH HHS R01 NS079157NINDS NIH HHS R21 NS084049
6 · The paper itself

Abstract

CD47 contributes to neuronal death, inflammation and angiogenesis after brain ischemia. The role of CD47 in intracerebral hemorrhage (ICH) has not been investigated and the current study examined brain CD47 expression in a pig ICH model. Pigs received a blood injection or needle insertion into the right frontal lobe and were euthanized at different times to examine CD47 expression. Pigs were also treated with an iron chelator, deferoxamine, (50mg/kg, i.m.) or vehicle and killed at day-3 to examine the effects on CD47. ICH resulted in upregulation of brain CD47 in both white and gray matter by both immunohistochemistry and Western blot. A time-course showed ICH-induced CD47 upregulation from 4h to day-14, with a peak at day-3. CD47 positive cells were neurons, microglia/macrophage and oliogodendrocytes. Brain CD47 levels were lower in the ipsilateral white and gray matter in pigs which had deferoxamine treatment. In conclusion, CD47 expression was increased in the perihematomal white and gray matter after ICH. Deferoxamine and iron may modulate CD47 expression.

Indexed as

AnimalsAstrocytesBrainCD47 AntigenCerebral HemorrhageDeferoxamineDisease Models, AnimalFunctional LateralityGray MatterIron Chelating AgentsMacrophagesMaleMicrogliaNeuronsOligodendrogliaSwineCD47 AntigenDeferoxamineIron Chelating AgentsCD47Cerebral hemorrhageDeferoxaminePig

Identifiers

PMID24931767
PMCPMC4121112
OpenAlexW2003508423

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.