ArticleInsect biochemistry and molecular biology2014
Juvenile hormone regulates Aedes aegypti Krüppel homolog 1 through a conserved E box motif.
Article in Insect biochemistry and molecular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 87 citations in OpenAlex.
- Involvement of Taiman in juvenile hormone signaling controlling sexual maturation in a male moth.Current research in insect science · 2026Article
- Identification of an atypical microRNA with sequence variation in the silkworm Bombyx mori.PloS one · 2026Article
- Histone deacetylases synergistically regulate juvenile hormone signaling in the yellow fever mosquito, Aedes aegypti.Insect biochemistry and molecular biology · 2025Article
- Possible Regulation of Larval Juvenile Hormone Titers inInsects · 2023Article
- Evolution of sex determination in crustaceans.Marine life science & technology · 2023Review
- Involvement of Methoprene-tolerant and Krüppel homolog 1 in juvenile hormone-mediated vitellogenesis of female Liposcelis entomophila (End.) (Psocoptera: Liposcelididae).Archives of insect biochemistry and physiology · 2023Article
- Knockdown ofBiology · 2022Article
- Juvenile hormone-induced histone deacetylase 3 suppresses apoptosis to maintain larval midgut in the yellow fever mosquito.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Review
- Purification of an insect juvenile hormone receptor complex enables insights into its post-translational phosphorylation.The Journal of biological chemistry · 2021Article
- Epoxidation of juvenile hormone was a key innovation improving insect reproductive fitness.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Coleopteran-specific StaufenC functions likeRNA biology · 2021Article
- Krüppel-homolog 1 exerts anti-metamorphic and vitellogenic functions in insects via phosphorylation-mediated recruitment of specific cofactors.BMC biology · 2021Article
- Detection of juvenile hormone agonists by a new reporter gene assay using yeast expressing Drosophila methoprene-tolerant.FEBS open bio · 2021Article
- Identification of juvenile hormone-induced posttranslational modifications of methoprene tolerant and Krüppel homolog 1 in the yellow fever mosquito, Aedes aegypti.Journal of proteomics · 2021Article
- Juvenile Hormone-Sensitive Ribosomal Activity Enhances Viral Replication in Aedes aegypti.mSystems · 2021Article
- Reporter gene assays for screening and identification of novel molting hormone- and juvenile hormone-like chemicals.Journal of pesticide science · 2021Article
- Involvement ofFrontiers in physiology · 2021Article
- CREB-binding protein regulates metamorphosis and compound eye development in the yellow fever mosquito, Aedes aegypti.Biochimica et biophysica acta. Gene regulatory mechanisms · 2020Article
- Double-stranded RNAs targeting inhibitor of apoptosis gene show no significant cross-species activity.Archives of insect biochemistry and physiology · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Juvenile hormone (JH) plays important roles in regulation of many physiological processes including development, reproduction and metabolism in insects. However, the molecular mechanisms of JH signaling pathway are not completely understood. To elucidate the molecular mechanisms of JH regulation of Krüppel homolog 1 gene (Kr-h1) in Aedes aegypti, we employed JH-sensitive Aag-2 cells developed from the embryos of this insect. In Aag-2 cells, AaKr-h1 gene is induced by nanomolar concentration of JH III, its expression peaked at 1.5 h after treatment with JH III. RNAi studies showed that JH induction of this gene requires the presence of Ae. aegypti methoprene-tolerant (AaMet). A conserved 13 nucleotide JH response element (JHRE, TGCCTCCACGTGC) containing canonical E box motif (underlined) identified in the promoter of AaKr-h1 is required for JH induction of this gene. Critical nucleotides in the JHRE required for JH action were identified by employing mutagenesis and reporter assays. Reporter assays also showed that basic helix loop helix (bHLH) domain of AaMet is required for JH induction of AaKr-h1. 5' rapid amplification of cDNA ends method identified two isoforms of AaKr-h1, AaKr-h1α and AaKr-h1β, the expression of both isoforms is induced by JH III, but AaKr-h1α is the predominant isoform in both Aag-2 cells and Ae. aegypti larvae.
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