ArticleGenetics2014
A simple regression-based method to map quantitative trait loci underlying function-valued phenotypes.
Article in Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Leveraging orthology within maize and Arabidopsis QTL to identify genes affecting natural variation in gravitropism.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Bayesian analysis of longitudinal traits in the Korea Association Resource (KARE) cohort.Genomics & informatics · 2022Article
- Correlation and co-localization of QTL for stomatal density, canopy temperature, and productivity with and without drought stress in Setaria.Journal of experimental botany · 2021Article
- Pleiotropy and epistasis within and between signaling pathways defines the genetic architecture of fungal virulence.PLoS genetics · 2021Article
- Functional QTL mapping and genomic prediction of canopy height in wheat measured using a robotic field phenotyping platform.Journal of experimental botany · 2020Article
- Integrating High-Throughput Phenotyping and Statistical Genomic Methods to Genetically Improve Longitudinal Traits in Crops.Frontiers in plant science · 2020Review
- A Gaussian process model and Bayesian variable selection for mapping function-valued quantitative traits with incomplete phenotypic data.Bioinformatics (Oxford, England) · 2019Article
- Three-Dimensional Time-Lapse Analysis Reveals Multiscale Relationships in Maize Root Systems with Contrasting Architectures.The Plant cell · 2019Article
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- The Quantitative Genetic Control of Root Architecture in Maize.Plant & cell physiology · 2018Article
- A machine vision platform for measuring imbibition of maize kernels: quantification of genetic effects and correlations with germination.Plant methods · 2018Article
- Sorghum Dw2 Encodes a Protein Kinase Regulator of Stem Internode Length.Scientific reports · 2017Article
- 3D Sorghum Reconstructions from Depth Images Identify QTL Regulating Shoot Architecture.Plant physiology · 2016Article
- Does 3D Phenotyping Yield Substantial Insights in the Genetics of the Mouse Mandible Shape?G3 (Bethesda, Md.) · 2016Article
- Mapping Quantitative Trait Loci Underlying Function-Valued Traits Using Functional Principal Component Analysis and Multi-Trait Mapping.G3 (Bethesda, Md.) · 2015Article
- Genetics of Rapid and Extreme Size Evolution in Island Mice.Genetics · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Most statistical methods for quantitative trait loci (QTL) mapping focus on a single phenotype. However, multiple phenotypes are commonly measured, and recent technological advances have greatly simplified the automated acquisition of numerous phenotypes, including function-valued phenotypes, such as growth measured over time. While methods exist for QTL mapping with function-valued phenotypes, they are generally computationally intensive and focus on single-QTL models. We propose two simple, fast methods that maintain high power and precision and are amenable to extensions with multiple-QTL models using a penalized likelihood approach. After identifying multiple QTL by these approaches, we can view the function-valued QTL effects to provide a deeper understanding of the underlying processes. Our methods have been implemented as a package for R, funqtl.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.