ArticleGenetics2014
A critical component of meiotic drive in Neurospora is located near a chromosome rearrangement.
Article in Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Divergence and conservation of the meiotic recombination machinery.Nature reviews. Genetics · 2024Review
- Enforcement of Postzygotic Species Boundaries in the Fungal Kingdom.Microbiology and molecular biology reviews : MMBR · 2022Review
- A-to-I mRNA editing controls spore death induced by a fungal meiotic drive gene in homologous and heterologous expression systems.Genetics · 2022Article
- Isolation ofmicroPublication biology · 2022Article
- Molecular Mechanisms and Evolutionary Consequences of Spore Killers in Ascomycetes.Microbiology and molecular biology reviews : MMBR · 2021Review
- Advances in understanding the evolution of fungal genome architecture.F1000Research · 2020Review
- A cross-eyed geneticist's view IV. Neurospora genes and inversions collude to cheat Mendel.Journal of biosciences · 2019Article
- Combinations ofeLife · 2019Article
- Fertility Costs of Meiotic Drivers.Current biology : CB · 2019Review
- Identification ofGenetics · 2019Article
- Convergent evolution of complex genomic rearrangements in two fungal meiotic drive elements.Nature communications · 2018Article
- Veni, vidi, vici: the success of wtf meiotic drivers in fission yeast.Yeast (Chichester, England) · 2018Review
- Genetic Villains: Killer Meiotic Drivers.Trends in genetics : TIG · 2018Review
- Article
- Article
- Crosses Heterozygous for Hybrid Neurospora Translocation Strains Show Transmission Ratio Distortion Disfavoring Homokaryotic Ascospores Made Following Alternate Segregation.G3 (Bethesda, Md.) · 2016Article
- A Meiotic Drive Element in the Maize Pathogen Fusarium verticillioides Is Located Within a 102 kb Region of Chromosome V.G3 (Bethesda, Md.) · 2016Article
- AFungal genetics reports · 2016Article
- Endogenous Small RNA Mediates Meiotic Silencing of a Novel DNA Transposon.G3 (Bethesda, Md.) · 2015Article
- Trichoderma reesei meiosis generates segmentally aneuploid progeny with higher xylanase-producing capability.Biotechnology for biofuels · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Neurospora fungi harbor a group of meiotic drive elements known as Spore killers (Sk). Spore killer-2 (Sk-2) and Spore killer-3 (Sk-3) are two Sk elements that map to a region of suppressed recombination. Although this recombination block is limited to crosses between Sk and Sk-sensitive (Sk(S)) strains, its existence has hindered Sk characterization. Here we report the circumvention of this obstacle by combining a classical genetic screen with next-generation sequencing technology and three-point crossing assays. This approach has allowed us to identify a novel locus called rfk-1, mutation of which disrupts spore killing by Sk-2. We have mapped rfk-1 to a 45-kb region near the right border of the Sk-2 element, a location that also harbors an 11-kb insertion (Sk-2(INS1)) and part of a >220-kb inversion (Sk-2(INV1)). These are the first two chromosome rearrangements to be formally identified in a Neurospora Sk element, providing evidence that they are at least partially responsible for Sk-based recombination suppression. Additionally, the proximity of these chromosome rearrangements to rfk-1 (a critical component of the spore-killing mechanism) suggests that they have played a key role in the evolution of meiotic drive in Neurospora.
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