ArticleAngewandte Chemie (International ed. in English)2014
Photodegradable hydrogels for capture, detection, and release of live cells.
Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Self-Immolative Gels: Programmable Degradation Using Self-Immolative Linkers and Polymers.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Spatial control of PEG-lipid interfaces at cell surface enables on-demand adhesion and enzymatic detachment of suspension cells.Science and technology of advanced materials · 2026Article
- Large-scale acoustic single cell trapping and selective releasing.Lab on a chip · 2025Article
- Preparation of Composite Hydrogels Based on Cysteine-Silver Sol and Methylene Blue as Promising Systems for Anticancer Photodynamic Therapy.Gels (Basel, Switzerland) · 2024Article
- Photoactive hydrogels for pre-concentration, labelling, and controlled release of proteins.The Analyst · 2023Article
- Cell therapy biomanufacturing: integrating biomaterial and flow-based membrane technologies for production of engineered T-cells.Advanced materials technologies · 2023Article
- Current Advances in 3D Bioprinting for Cancer Modeling and Personalized Medicine.International journal of molecular sciences · 2022Review
- Spatiotemporal patterning of photoresponsive DNA-based hydrogels to tune local cell responses.Nature communications · 2021Article
- Core-shell hydrogel microcapsules enable formation of human pluripotent stem cell spheroids and their cultivation in a stirred bioreactor.Scientific reports · 2021Article
- Three-Dimensional Avian Hematopoietic Stem Cell Cultures as a Model for Studying Disease Pathogenesis.Frontiers in cell and developmental biology · 2021Review
- Next-Generation Biomaterials for Culture and Manipulation of Stem Cells.Cold Spring Harbor perspectives in biology · 2020Article
- Photo-Cleavable Peptide-Poly(Ethylene Glycol) Conjugate Surfaces for Light-Guided Control of Cell Adhesion.Micromachines · 2020Article
- Probe-target hybridization depends on spatial uniformity of initial concentration condition across large-format chips.Scientific reports · 2020Article
- Imaging-assisted hydrogel formation for single cell isolation.Scientific reports · 2020Article
- Immunofunctional photodegradable poly(ethylene glycol) hydrogel surfaces for the capture and release of rare cells.Colloids and surfaces. B, Biointerfaces · 2019Article
- Designing Photolabile Ruthenium Polypyridyl Crosslinkers for Hydrogel Formation and Multiplexed, Visible-light Degradation.RSC advances · 2019Article
- Squaramide-Based Supramolecular Materials for Three-Dimensional Cell Culture of Human Induced Pluripotent Stem Cells and Their Derivatives.Biomacromolecules · 2018Article
- Multiorgan Microphysiological Systems for Drug Development: Strategies, Advances, and Challenges.Advanced healthcare materials · 2018Review
- Controlling the Release of Small, Bioactive Proteins via Dual Mechanisms with Therapeutic Potential.Advanced healthcare materials · 2017Article
- Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment.Chemical reviews · 2017Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Cells may be captured and released using a photodegradable hydrogel (photogel) functionalized with antibodies. Photogel substrates were used to first isolate human CD4 or CD8 T-cells from a heterogeneous cell suspension and then to release desired cells or groups of cells by UV-induced photodegradation. Flow cytometry analysis of the retrieved cells revealed approximately 95% purity of CD4 and CD8 T-cells, suggesting that this substrate had excellent specificity. To demonstrate the possibility of sorting cells according to their function, photogel substrates that were functionalized with anti-CD4 and anti-TNF-α antibodies were prepared. Single cells captured and stimulated on such substrates were identified by the fluorescence "halo" after immunofluorescent staining and could be retrieved by site-specific exposure to UV light through a microscope objective. Overall, it was demonstrated that functional photodegradable hydrogels enable the capture, analysis, and sorting of live cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.