Evidence map›Paper›PMID 24931043›Full record

ReviewNature reviews. Microbiology2014

Motility and more: the flagellum of Trypanosoma brucei.

Gerasimos Langousis, Kent L Hill

Abstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 1 pooled it
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 1 synthesis or guideline pooled it, 193 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Form and function in biological filaments: a physicist's review.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025
    Review
  8. CryoEM structure of thebioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. Modelling motility of Trypanosoma brucei.PLoS computational biology · 2025
    Article
  11. Article
  12. Article
  13. FAP20 is required for flagellum assembly inMolecular biology of the cell · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. FAP20 is required for flagellum assembly inbioRxiv : the preprint server for biology · 2024
    Article
  18. Article
  19. FAZ assembly in bloodstream formMolecular biology of the cell · 2023
    Article
  20. Article

43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Gerasimos LangousisDepartment of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California 90095, USA.
Kent L Hill1] Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California 90095, USA. [2] Molecular Biology Institute, University of California, Los Angeles, California 90095, USA.
University of California, Los Angeles · US

Funding

Biochemical and Functional Analysis of TrypaninR01AI052348 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HILL, KENT L · 2002 to 2023
$7.4M
Host-specific cell surface receptors on African trypanosomesR21AI094333 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HILL, KENT L · 2012 to 2013
$424k
NIAID NIH HHS R01 AI052348NIAID NIH HHS R01AI052348NIAID NIH HHS R21 AI094333NIAID NIH HHS R21AI094333
6 · The paper itself

Abstract

Trypanosoma brucei is a pathogenic unicellular eukaryote that infects humans and other mammals in sub-Saharan Africa. A central feature of trypanosome biology is the single flagellum of the parasite, which is an essential and multifunctional organelle that facilitates cell propulsion, controls cell morphogenesis and directs cytokinesis. Moreover, the flagellar membrane is a specialized subdomain of the cell surface that mediates attachment to host tissues and harbours multiple virulence factors. In this Review, we discuss the structure, assembly and function of the trypanosome flagellum, including canonical roles in cell motility as well as novel and emerging roles in cell morphogenesis and host-parasite interactions.

Indexed as

AnimalsCell DivisionCell MovementFlagellaHost-Parasite InteractionsHumansInsect VectorsTrypanosoma brucei bruceiTrypanosomiasis, AfricanTsetse Flies

Identifiers

PMID24931043
PMCPMC4278896
OpenAlexW2072340281

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.