ArticleToxicology letters2014
Manganese accumulation in bone following chronic exposure in rats: steady-state concentration and half-life in bone.
Article in Toxicology letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 88 citations in OpenAlex.
- Developmental manganese exposure, but not concurrent lead, alters social processing selectively in male mice.iScience · 2026Article
- Manganese: biology, physiology and role in disease.Cell discovery · 2026Review
- The interplay of iron status and manganese biomarkers in U.S. females: NHANES 2015-2018 analysis.Metallomics : integrated biometal science · 2025Article
- Article
- Manganese: From Soil to Human Health-A Comprehensive Overview of Its Biological and Environmental Significance.Nutrients · 2024Review
- Metabolomic and Lipidomic Analysis of Manganese-Associated Parkinsonism: a Case-Control Study in Brescia, Italy.medRxiv : the preprint server for health sciences · 2024Article
- The Manganese-Bone Connection: Investigating the Role of Manganese in Bone Health.Journal of clinical medicine · 2024Review
- Child and Adolescent Manganese Biomarkers and Adolescent Postural Balance in Marietta CARES Cohort Participants.Environmental health perspectives · 2024Article
- The association of manganese levels with red cell distribution width: A population-based study.PloS one · 2024Article
- Association of per- and polyfluoroalkylated substances/heavy metals and bone health in children and adolescents.Frontiers in public health · 2024Article
- Scientific opinion on the tolerable upper intake level for manganese.EFSA journal. European Food Safety Authority · 2023Article
- Heavy metals in drinking water and periodontitis: evidence from the national oral health survey from China.BMC public health · 2023Article
- A State-of-the-Science Review on Metal Biomarkers.Current environmental health reports · 2023Review
- Determination of Concentration of Metals in Grapes Grown in Gonabad Vineyards and Assessment of Associated Health Risks.Biological trace element research · 2023Article
- FeMn and FeMnAg biodegradable alloys: AnHeliyon · 2023Article
- Impact of Environmental Risk Factors on Mitochondrial Dysfunction, Neuroinflammation, Protein Misfolding, and Oxidative Stress in the Etiopathogenesis of Parkinson's Disease.International journal of molecular sciences · 2022Review
- The Abundance of Trace Elements in Human Bone Relative to Bone Type and Bone Pathology.GeoHealth · 2022Article
- Lipid headgroup and side chain architecture determine manganese-induced dose dependent membrane rigidification and liposome size increase.European biophysics journal : EBJ · 2022Article
- Bone manganese is a sensitive biomarker of ongoing elevated manganese exposure, but does not accumulate across the lifespan.Environmental research · 2022Article
- Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Literature data indicate that bone is a major storage organ for manganese (Mn), accounting for 43% of total body Mn. However, the kinetic nature of Mn in bone, especially the half-life (t(1/2)), remained unknown. This study was designed to understand the time-dependence of Mn distribution in rat bone after chronic oral exposure. Adult male rats received 50 mg Mn/kg (as MnCl2) by oral gavage, 5 days per week, for up to 10 weeks. Animals were sacrificed every 2 weeks during Mn administration for the uptake study, and on day 1, week 2, 4, 8, or 12 after the cessation at 6-week Mn exposure for the t(1/2) study. Mn concentrations in bone (MnBn) were determined by AAS analysis. By the end of 6-week's treatment, MnBn appeared to reach the steady state (T(ss)) level, about 2-3.2 fold higher than MnBn at day 0. Kinetic calculation revealed t(1/2)s of Mn in femur, tibia, and humerus bone of 77 (r=0.978), 263 (r=0.988), and 429 (r=0.994) days, respectively; the average t(1/2) in rat skeleton was about 143 days, equivalent to 8.5 years in human bone. Moreover, MnBn were correlated with Mn levels in striatum, hippocampus, and CSF. These data support MnBn to be a useful biomarker of Mn exposure.
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