ArticleMedical oncology (Northwood, London, England)2014
URG11 predicts poor prognosis of pancreatic cancer by enhancing epithelial-mesenchymal transition-driven invasion.
Article in Medical oncology (Northwood, London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Prognostic Analysis of Lactic Acid Metabolism Genes in Oral Squamous Cell Carcinoma.International dental journal · 2024Article
- Expression Analysis of Early Metastatic Seeding of Colorectal Cancer.Annals of surgical oncology · 2024Article
- VWCE as a potential biomarker associated with immune infiltrates in breast cancer.Cancer cell international · 2021Article
- Monosomy 3 Influences Epithelial-Mesenchymal Transition Gene Expression in Uveal Melanoma Patients; Consequences for Liquid Biopsy.International journal of molecular sciences · 2020Article
- VWCE Functions as a Tumor Suppressor in Breast Cancer Cells.Frontiers in oncology · 2020Article
- URG11 promotes proliferation and induced apoptosis of LNCaP cells.International journal of molecular medicine · 2019Article
- URG11 Regulates Prostate Cancer Cell Proliferation, Migration, and Invasion.BioMed research international · 2018Article
- LncRNA NEAT1 Impacts Cell Proliferation and Apoptosis of Colorectal Cancer via Regulation of Akt Signaling.Pathology oncology research : POR · 2017Article
- LincRNA-p21 predicts favorable clinical outcome and impairs tumorigenesis in diffuse large B cell lymphoma patients treated with R-CHOP chemotherapy.Clinical and experimental medicine · 2017Article
- Knockdown of Upregulated Gene 11 (URG11) Inhibits Proliferation, Invasion, and β-Catenin Expression in Non-Small Cell Lung Cancer Cells.Oncology research · 2016Article
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Authors and funding
3 authors at 3 institutions in 1 country.
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Abstract
The poor prognosis and high recurrent rate of pancreatic cancer (PC) necessitates the discovery of new predictive markers of PC invasion and prognosis. In this study, we evaluated the expression pattern of up-regulated gene 11 (URG11) in a tissue microarray with 18 pairs of PC and adjacent normal tissues. It was shown that URG11 was significantly up-regulated in PC tissues. High expression levels of URG11 were detected in all PC specimens, but were rarely detected in adjacent non-tumorous tissues. In addition, high expression of URG11 was correlated to poor prognosis. Furthermore, it was discovered that URG11 was correlated to epithelial-mesenchymal transition (EMT) markers and clinical pathological parameters indicative of high PC invasion, while knockdown of URG11 significantly changed the expression pattern of EMT markers and decreased the invasion of PC cells. These findings indicate that URG11 might enhance the invasion of PC by inducing EMT and thus lead to poor PC prognosis. Thus, URG11 has the potential to be a new predictive biomarker of PC invasion and prognosis, which may help in the diagnosis and treatment of PC patients.
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