ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2015
Optimizing electrical impedance myography measurements by using a multifrequency ratio: a study in Duchenne muscular dystrophy.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Electrical Impedance Myography in Health and Physical Exercise: A Systematic Review and Future Perspectives.Frontiers in physiology · 2021Pooled it
- Inter-session reliability of electrical impedance myography in children in a clinical trial setting.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2015Trial
- Multifrequency Electrical Impedance Myography Enhanced with Machine Learning for Screening Patients with Neuromuscular Disorders.Annals of biomedical engineering · 2026Article
- Electrical impedance myography captures features of muscle structure measured by MRI and transcriptomic analysis in facioscapulohumeral muscular dystrophy.Journal of neuromuscular diseases · 2026Article
- 0.33Science advances · 2026Article
- Electrical impedance myography as a marker of muscle mass in rats with simulated Anorexia Nervosa.Journal of electrical bioimpedance · 2025Article
- Machine learning-enhanced electrical impedance myography to diagnose and track spinal muscular atrophy progression.Physiological measurement · 2024Article
- Electrical impedance myography detects dystrophin-related muscle changes in mdx mice.Skeletal muscle · 2023Article
- Feasibility Analysis and Implementation of Head-Mounted Electrical Impedance Respiratory Monitoring.Biosensors · 2022Article
- Performing In Vivo and Ex Vivo Electrical Impedance Myography in Rodents.Journal of visualized experiments : JoVE · 2022Article
- Estimating myofiber cross-sectional area and connective tissue deposition with electrical impedance myography: A study in D2-mdx mice.Muscle & nerve · 2021Article
- Electrical impedance myography: A critical review and outlook.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021Review
- Interrater and Intrarater Reliability of Electrical Impedance Myography: A Comparison between Large and Small Handheld Electrode Arrays.Journal of healthcare engineering · 2021Article
- Exploring the relationship between electrical impedance myography and quantitative ultrasound parameters in Duchenne muscular dystrophy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2019Article
- Separation of Subcutaneous Fat From Muscle in Surface Electrical Impedance Myography Measurements Using Model Component Analysis.IEEE transactions on bio-medical engineering · 2019Article
- Reducing sample size requirements for future ALS clinical trials with a dedicated electrical impedance myography system.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2018Article
- Electrical impedance myography in facioscapulohumeral muscular dystrophy: A 1-year follow-up study.Muscle & nerve · 2018Observational
- Electrical impedance myography in individuals with collagen 6 and laminin α-2 congenital muscular dystrophy: a cross-sectional and 2-year analysis.Muscle & nerve · 2018Article
- Non-invasive assessment of muscle injury in healthy and dystrophic animals with electrical impedance myography.Muscle & nerve · 2017Article
- Sensitivity distribution simulations of surface electrode configurations for electrical impedance myography.Muscle & nerve · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveElectrical impedance myography (EIM) is an electrophysiological technique for neuromuscular evaluation that is impacted by subcutaneous fat (SF). Exploiting the differing frequency dependences of muscle and fat, we assessed a 2-frequency EIM phase ratio in Duchenne muscular dystrophy (DMD) boys.
methodsTwenty-eight DMD boys aged 2-13years underwent EIM and the 6-minute walk test (6MWT). For each subject, 50kHz phase data was input into the numerator while 20-500kHz phase values were input into the denominator. We then performed correlation analyses seeking to identify the denominator frequency that simultaneously optimized SF and 6MWT correlations. This optimized ratio was then tested in 24 healthy boys.
results50kHz phase correlated to 6MWT in DMD boys with R=0.52, p=0.0066, and to SF thickness with R=-0.67, p<0.001. An optimized ratio of 50/200kHz phase reduced the correlation of SF thickness to R=-0.075, p=0.45 while improving the relationship to the 6MWT (R=0.60, p=0.001). In normal subjects, the optimization decreased SF correlation from R=0.61 from R=0.16 with 6MWT correlation remaining unchanged.
conclusionsThe 50/200kHz EIM phase ratio removes the impact of SF while maintaining EIM's association with function. SIGNIFICANCE: The use of a phase ratio may enhance EIM's application for evaluation of neuromuscular disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.