ReviewTrends in neurosciences2014
Prefrontal cortical regulation of fear learning.
Review in Trends in neurosciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
109 citing papers in PubMed, 1 synthesis or guideline pooled it, 195 citations in OpenAlex.
- The impact of affective information on working memory: A pair of meta-analytic reviews of behavioral and neuroimaging evidence.Psychological bulletin · 2019Pooled it
- Prefrontal-raphe-habenular circuit drives fear memory recall and updating.Nature communications · 2026Article
- A ventral striatal learning signal reflecting individual differences in the success of fear extinction.Molecular psychiatry · 2026Article
- Oxytocin attenuates fear learning via enhancing somatostatin interneuron-mediated local GABAergic inhibition in the prelimbic cortex.Science advances · 2026Article
- Adolescent Stress Exposure: Behavioral Consequences and Molecular Mechanisms in Corticolimbic Networks.bioRxiv : the preprint server for biology · 2026Article
- Prefrontal chandelier cells encode stimulus salience to influence learning in male mice.Nature communications · 2026Article
- MASSAG model: Towards an integrative neuroscience framework linking emotional trauma, pain, and mechanisms of force-based manipulations.Neuroscience and biobehavioral reviews · 2026Review
- A Prefrontal Neuromodulation Route for Post-Traumatic Olfactory Dysfunction: A Perspective Supported by Recovery During Left-DLPFC rTMS.Brain sciences · 2026Article
- Representational dynamics during extinction of fear memories in the human brain.Nature human behaviour · 2026Article
- Adolescent stress exposure: behavioral consequences and molecular mechanisms in corticolimbic networks.Frontiers in cellular neuroscience · 2026Article
- Article
- Integrating Aversive Memories in the Basolateral Amygdala.Biological psychiatry · 2025Review
- Developmental differences in threat learning are associated with changes in frontal-central theta activity.European child & adolescent psychiatry · 2025Article
- Article
- The locus coeruleus influences behavior by coordinating effective integration of fear memories and sensory input.PLoS biology · 2025Article
- Not the same as it ever was: A review of memory modification, updating, and distortion in humans and rodents.Neuroscience and biobehavioral reviews · 2025Review
- Microglial repopulation reverses radiation-induced cognitive dysfunction by restoring medial prefrontal cortex activity and modulating leukotriene-C4 synthesis.Acta neuropathologica communications · 2025Article
- Extinction of contextual fear memory is facilitated in TRPM2 knockout mice.Molecular brain · 2025Article
- The Role of Basolateral Amygdala and Medial Prefrontal Cortex in Fear: A Systematic Review.Cureus · 2025Review
- Dissociable dorsal medial prefrontal cortex ensembles are necessary for cocaine seeking and fear conditioning in mice.Translational psychiatry · 2024Article
49 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The prefrontal cortex regulates the expression of fear based on previously learned information. Recently, this brain area has emerged as being crucial in the initial formation of fear memories, providing new avenues to study the neurobiology underlying aberrant learning in anxiety disorders. Here we review the circumstances under which the prefrontal cortex is recruited in the formation of memory, highlighting relevant work in laboratory animals and human subjects. We propose that the prefrontal cortex facilitates fear memory through the integration of sensory and emotional signals and through the coordination of memory storage in an amygdala-based network.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.