Evidence map›Paper›PMID 24929828›Full record

ArticleNature genetics2014

Genome-wide association analysis identifies six new loci associated with forced vital capacity.

Daan W Loth, María Soler Artigas, Sina A Gharib, Louise V Wain, Nora Franceschini, Beate Koch, Tess D Pottinger, Albert Vernon Smith, Qing Duan, Chris Oldmeadow and 150 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 3 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 3 syntheses or guidelines pooled it, 148 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

160 authors at 20 institutions in 15 countries.

Daan W Loth1] Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands. [2] Netherlands Health Care Inspectorate, The Hague, the Netherlands. [3].
María Soler Artigas1] Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK. [2] National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK. [3].
Sina A Gharib1] Computational Medicine Core, Center for Lung Biology, University of Washington, Seattle, Washington, USA. [2] Department of Medicine, University of Washington, Seattle, Washington, USA. [3].
Louise V Wain1] Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK. [2] National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK. [3].
Nora Franceschini1] Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. [2] Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. [3].
Beate Koch1] Department of Internal Medicine B-Pneumology, Cardiology, Intensive Care and Infectious Diseases, University Hospital Greifswald, Greifswald, Germany. [2].
Tess D Pottinger1] Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA. [2].
Albert Vernon Smith1] Iceland Heart Association, Kopavogur, Iceland. [2] University of Iceland, Reykjavik, Iceland. [3].
Qing Duan1] Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA. [2].
Chris Oldmeadow1] Hunter Medical Research Institute, University of Newcastle, Newcastle, New South Wales, Australia. [2] Faculty of Health, University of Newcastle, Newcastle, New South Wales, Australia.
Mi Kyeong LeeInstitute of Health and Environment, Seoul National University, Seoul, South Korea.
David P StrachanDivision of Population Health Sciences and Education, St George's, University of London, London, UK.
Alan L James1] Department of Pulmonary Physiology and Sleep Medicine/West Australian Sleep Disorders Research Institute, Nedlands, Western Australia, Australia. [2] School of Medicine and Pharmacology, The University of Western Australia, Perth, Western Australia, Australia. [3] Busselton Population Medical Research Institute, Busselton, Western Australia, Australia.
Jennifer E HuffmanMedical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK.
Veronique VitartMedical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK.
Adaikalavan Ramasamy1] Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, UK. [2] Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Nicholas J WarehamMRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Jaakko Kaprio1] Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland. [2] National Institute for Health and Welfare (THL), Helsinki, Finland. [3] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Xin-Qun WangDivision of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA.
Holly TrochetMedical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK.
Mika KähönenDepartment of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland.
Claudia FlexederInstitute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Eva AlbrechtInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Lorna M Lopez1] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. [2] Department of Psychology, University of Edinburgh, Edinburgh, UK.ORCID 0000000202419783
Kim de Jong1] Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. [2] Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Bharat ThyagarajanDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.
Alexessander Couto AlvesDepartment of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Stefan Enroth1] Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden. [2] Science for Life Laboratory, Uppsala University, Uppsala, Sweden.ORCID 0000000250569137
Ernst Omenaas1] Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway. [2] Department of Clinical Sciences, University of Bergen, Bergen, Norway.
Peter K JoshiCentre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, UK.
Tove Fall1] Science for Life Laboratory, Uppsala University, Uppsala, Sweden. [2] Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Ana ViñuelaDepartment of Twins Research and Genetic Epidemiology, King's College London, London, UK.ORCID 0000000337718537
Lenore J LaunerLaboratory of Epidemiology, Demography and Biometry, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA.
Laura R Loehr1] Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. [2] Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Myriam Fornage1] Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA. [2] Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Guo LiCardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA.
Jemma B WilkPrecision Medicine, Pfizer Global Research and Development, Cambridge, Massachusetts, USA.
Wenbo TangDivision of Nutritional Sciences, Cornell University, Ithaca, New York, USA.
Ani Manichaikul1] Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA. [2] Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.
Lies Lahousse1] Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands. [2] Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
Tamara B HarrisLaboratory of Epidemiology, Demography and Biometry, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA.
Kari E NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Alicja R RudnickaDivision of Population Health Sciences and Education, St George's, University of London, London, UK.
Jennie HuiPathWest Laboratory Medicine Washington, Nedlands, Western Australia, Australia.
Xiangjun Gu1] Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA. [2] Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Thomas LumleyDepartment of Statistics, University of Auckland, Auckland, New Zealand.
Alan F WrightMedical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK.
Nicholas D HastieMedical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK.
Susan CampbellMedical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK.
Rajesh KumarNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Isabelle Pin1] Centre Hospitalier Universitaire de Grenoble, Grenoble, France. [2] INSERM U823, Institut Albert Bonniot, Grenoble, France. [3] Université Joseph Fourier, Grenoble, France.
Robert A ScottMRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Kirsi H Pietiläinen1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. [2] Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland. [3] Division of Internal Medicine, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.
Ida Surakka1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. [2] Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Helsinki, Finland.
Yongmei LiuDepartment of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Elizabeth G Holliday1] Hunter Medical Research Institute, University of Newcastle, Newcastle, New South Wales, Australia. [2] Faculty of Health, University of Newcastle, Newcastle, New South Wales, Australia.
Holger SchulzInstitute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Joachim Heinrich1] Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. [2] Comprehensive Pneumology Center Munich (CPC-M), member of the German Center for Lung Research, Munich, Germany.ORCID 0000000296201629
Gail Davies1] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. [2] Department of Psychology, University of Edinburgh, Edinburgh, UK. [3] Medical Genetics Section, Centre for Genomics and Experimental Medicine, MRC IGMM, University of Edinburgh, Edinburgh, UK. [4] MRC Institute of Genetics and Molecular Medicine, Edinburgh, UK.
Judith M Vonk1] Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. [2] Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Mary WojczynskiDepartment of Statistical Genomics, Washington University, St. Louis, Missouri, USA.
Anneli Pouta1] National Institute for Health and Welfare, Oulu, Finland. [2] Department of Clinical Sciences/Obstetrics and Gynecology, University Hospital of Oulu, University of Oulu, Oulu, Finland.
Asa Johansson1] Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden. [2] Science for Life Laboratory, Uppsala University, Uppsala, Sweden. [3] Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.ORCID 0000000229154498
Sarah H WildCentre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, UK.
Erik Ingelsson1] Science for Life Laboratory, Uppsala University, Uppsala, Sweden. [2] Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. [3] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Fernando Rivadeneira1] Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands. [2] Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Pirro G HysiDepartment of Twins Research and Genetic Epidemiology, King's College London, London, UK.
Gudny EiriksdottirIceland Heart Association, Kopavogur, Iceland.
Alanna C MorrisonSchool of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Jerome I Rotter1] Biomedical Research Institute, Harbor-University of California, Los Angeles (UCLA) Medical Center, Torrance, California, USA. [2] Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, USA.
Wei GaoDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Dirkje S Postma1] Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. [2] Department of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Wendy B WhiteTougaloo College, Jackson, Mississippi, USA.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.
Albert Hofman1] Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands. [2] Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands.
Thor Aspelund1] Iceland Heart Association, Kopavogur, Iceland. [2] University of Iceland, Reykjavik, Iceland.
David CouperDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Lewis J SmithNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Bruce M Psaty1] Department of Medicine, University of Washington, Seattle, Washington, USA. [2] Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA. [3] Department of Epidemiology, University of Washington, Seattle, Washington, USA. [4] Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA.
Kurt LohmanDepartment of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Esteban G Burchard1] Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, USA. [2] Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
André G Uitterlinden1] Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands. [2] Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands. [3] Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands.
Melissa GarciaLaboratory of Epidemiology, Demography and Biometry, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA.
Bonnie R JoubertEpidemiology Branch, National Institute of Environmental Health Sciences, US National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, North Carolina, USA.
Wendy L McArdleSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
A Bill MuskDepartment of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
Nadia HanselDepartment of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Susan R Heckbert1] Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA. [2] Department of Epidemiology, University of Washington, Seattle, Washington, USA. [3] Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA.
Lina Zgaga1] Department of Public Health and Primary Care, Trinity College Dublin, Dublin, Ireland. [2] Adrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb, Croatia.
Joyce B J van Meurs1] Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands. [2] Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands.
Pau NavarroMedical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK.
Igor RudanCentre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, UK.ORCID 0000000169936884
Yeon-Mok Oh1] Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. [2] Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Susan RedlineDepartment of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Deborah L Jarvis1] Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, UK. [2] MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.
Jing Hua ZhaoMRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Taina RantanenGerontology Research Centre, Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
George T O'Connor1] Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts, USA. [2] National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA.
Samuli Ripatti1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. [2] Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Helsinki, Finland. [3] Genetic Epidemiology Group, Wellcome Trust Sanger Institute, Hinxton, UK.
Rodney J Scott1] Hunter Medical Research Institute, University of Newcastle, Newcastle, New South Wales, Australia. [2] Faculty of Health, University of Newcastle, Newcastle, New South Wales, Australia.
Stefan Karrasch1] Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. [2] Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig Maximilians Universität, Munich, Germany. [3] Institute of General Practice, University Hospital Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
Harald GrallertResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Nathan C GaddisResearch Computing Division, Research Triangle Institute International, Research Triangle Park, North Carolina, USA.
John M Starr1] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. [2] Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.
Cisca WijmengaDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Ryan L MinsterDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
David J Lederer1] Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA. [2] Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
Juha Pekkanen1] Department of Environmental Health, National Institute for Health and Welfare (THL), Kuopio, Finland. [2] Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Ulf Gyllensten1] Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden. [2] Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Harry CampbellCentre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, UK.
Andrew P MorrisWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Sven GläserDepartment of Internal Medicine B-Pneumology, Cardiology, Intensive Care and Infectious Diseases, University Hospital Greifswald, Greifswald, Germany.
Christopher J HammondDepartment of Twins Research and Genetic Epidemiology, King's College London, London, UK.ORCID 0000000232272620
Kristin M BurkartDepartment of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
John BeilbyPathWest Laboratory Medicine Washington, Nedlands, Western Australia, Australia.
Stephen B KritchevskySticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Vilmundur Gudnason1] Iceland Heart Association, Kopavogur, Iceland. [2] University of Iceland, Reykjavik, Iceland.
Dana B Hancock1] Epidemiology Branch, National Institute of Environmental Health Sciences, US National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, North Carolina, USA. [2] Behavioral Health Epidemiology Program, Research Triangle Institute International, Research Triangle Park, North Carolina, USA.
O Dale WilliamsFlorida International University, Miami, Florida, USA.
Ozren PolasekDepartment of Public Health, Medical School, University of Split, Split, Croatia.
Tatijana ZemunikDepartment of Medical Biology, Medical School, University of Split, Split, Croatia.
Ivana KolcicDepartment of Public Health, Medical School, University of Split, Split, Croatia.
Marcy F PetriniDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Matthias WjstComprehensive Pneumology Center (CPC), Helmholtz Zentrum München (HMGU), Munich, Germany.
Woo Jin Kim1] Department of Internal Medicine, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea. [2] Environmental Health Center, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea.
David J PorteousMedical Genetics Section, Centre for Genomics and Experimental Medicine, MRC IGMM, University of Edinburgh, Edinburgh, UK.
Generation ScotlandA collaboration between the University Medical Schools and National Health Service (NHS) in Aberdeen, Dundee, Edinburgh and Glasgow, UK.
Blair H SmithMedical Research Institute, University of Dundee, Dundee, UK.
Anne ViljanenGerontology Research Centre, Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
Markku HeliövaaraNational Institute for Health and Welfare (THL), Helsinki, Finland.
John R Attia1] Hunter Medical Research Institute, University of Newcastle, Newcastle, New South Wales, Australia. [2] Faculty of Health, University of Newcastle, Newcastle, New South Wales, Australia.
Ian SayersDivision of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, UK.
Regina HampelInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Christian GiegerInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Ian J Deary1] Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. [2] Department of Psychology, University of Edinburgh, Edinburgh, UK.
H Marike Boezen1] Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. [2] Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Anne NewmanDepartment of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Marjo-Riitta Jarvelin1] Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK. [2] Institute of Health Sciences, University of Oulu, Oulu, Finland. [3] Biocenter Oulu, University of Oulu, Oulu, Finland. [4] Unit of Primary Care, Oulu University Hospital, Oulu, Finland. [5] Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland.
James F WilsonCentre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, UK.
Lars LindDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Bruno H Stricker1] Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands. [2] Netherlands Health Care Inspectorate, The Hague, the Netherlands. [3] Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands. [4] Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands.
Alexander TeumerDepartment for Genetics and Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.ORCID 000000028309094X
Timothy D SpectorDepartment of Twins Research and Genetic Epidemiology, King's College London, London, UK.
Erik MelénInstitute of Environmental Medicine, Karolinska Institutet and Sachs' Children's Hospital, Stockholm, Sweden.
Marjolein J Peters1] Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands. [2] Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, the Netherlands.
Leslie A LangeDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.
R Graham Barr1] Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA. [2] Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
Ken R BrackeDepartment of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
Fien M VerhammeDepartment of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
Joohon Sung1] Institute of Health and Environment, Seoul National University, Seoul, South Korea. [2] Complex Disease and Genetic Epidemiology Branch, Department of Epidemiology, Seoul National University School of Public Health, Seoul, South Korea.
Pieter S HiemstraDepartment of Pulmonology, Leiden University Medical Center, Leiden, the Netherlands.
Patricia A Cassano1] Division of Nutritional Sciences, Cornell University, Ithaca, New York, USA. [2] Department of Public Health, Division of Biostatistics and Epidemiology, Weill Cornell Medical College, New York, New York, USA.
Akshay Sood1] University of New Mexico Health Sciences Center School of Medicine, Albuquerque, New Mexico, USA. [2].
Caroline Hayward1] Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK. [2].
Josée Dupuis1] Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA. [2] National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA. [3].
Ian P Hall1] Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, UK. [2].
Guy G Brusselle1] Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands. [2] Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium. [3] Department of Respiratory Medicine, Erasmus MC, Rotterdam, the Netherlands. [4].
Martin D Tobin1] Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK. [2] National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK. [3].
Stephanie J London1] Epidemiology Branch, National Institute of Environmental Health Sciences, US National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, North Carolina, USA. [2].
Institute of Genetics and Cancer · GBHelmholtz Zentrum München · DEUniversity of Edinburgh · GBNational Institutes of Health · USUniversity of North Carolina at Chapel Hill · USUppsala University · SEErasmus MC · NLHunter Medical Research Institute · AUUniversity Medical Center Groningen · NLColumbia University · USGhent University Hospital · BEKing's College London · GBUniversitätsmedizin Greifswald · DEUniversity of Helsinki · FIBoston University · USThe University of Texas Health Science Center at Houston · USUniversity of Split · HRWake Forest University · USAddenbrooke's Hospital · GBCornell University · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
Long Life Family Study: Data Management and Coordinating CenterU01AG023746 · NIA · WASHINGTON UNIVERSITY · PI PROVINCE, MICHAEL A. · 2004 to 2018
$29.2M
Pulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8M
Plasma beta-amyloid in long lived families: genetics and risk of ADU01AG023749 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI COSENTINO, STEPHANIE ANN, LEE, JOSEPH HYUNGWOO · 2004 to 2018
$13.0M
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Genetics and Environment in Adult Respiratory, Allergic and Cardiac diseaseZIAES043012 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE · 2009 to 2025
$6.4M
Subclinical Interstitial Lung Disease in MESA and FAR-ILDR01HL103676 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GARCIA, CHRISTINE KIM · 2011 to 2020
$6.4M
CLINICAL PROJECT: Age, Gene/Environment Susceptibility Study on the Multi-omics of Aging: A clinical epidemiologic prospective studyZIAAG007380 · NIA · NATIONAL INSTITUTE ON AGING · PI LAUNER, LENORE J · 2009 to 2025
$6.1M
The Brown Initiative in HIV and AIDS Clinical Research for Minority CommunitiesR25MH083620 · NIMH · MIRIAM HOSPITAL · PI NUNN, AMY STEWART · 2008 to 2025
$3.7M
Biotechnology and Biological Sciences Research Council BB/F019394/1Chief Scientist Office CZB/4/505Chief Scientist Office CZB/4/710Chief Scientist Office CZD/16/6/4Chief Scientist Office ETM/55Department of Health SRF/01/010Intramural NIH HHS Z01 ES043012Medical Research Council G0100266Medical Research Council G0700704Medical Research Council G0701863Medical Research Council G0902313Medical Research Council G1000861Medical Research Council MC_PC_U127561128Medical Research Council MC_PC_U127592696Medical Research Council MC_U106179471Medical Research Council MC_UU_12015/1Medical Research Council MR/K026992/1Medical Research Council MR/L016400/1NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001079NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL103676NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL117078NIA NIH HHS R01 AG023629NIA NIH HHS U01 AG023746NIA NIH HHS U01 AG023749NIDDK NIH HHS P30 DK063491NIMH NIH HHS R25 MH083620
6 · The paper itself

Abstract

Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P < 5 × 10(-8)) with FVC in or near EFEMP1, BMP6, MIR129-2-HSD17B12, PRDM11, WWOX and KCNJ2. Two loci previously associated with spirometric measures (GSTCD and PTCH1) were related to FVC. Newly implicated regions were followed up in samples from African-American, Korean, Chinese and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and the pathogenesis of restrictive lung disease.

Indexed as

Genome, HumanGenome-Wide Association StudyCohort StudiesDatabases, GeneticFollow-Up StudiesForced Expiratory VolumeGenetic LociGenetic Predisposition to DiseaseHumansLung DiseasesMeta-Analysis as TopicPolymorphism, Single NucleotidePrognosisQuantitative Trait LociRespiratory Function TestsSpirometry

Identifiers

PMID24929828
PMCPMC4140093
OpenAlexW2007669329

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.