ArticleBMC systems biology2014
Network-dosage compensation topologies as recurrent network motifs in natural gene networks.
Article in BMC systems biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 13 citations in OpenAlex.
- Article
- Intrinsic health as a foundation for a science of health.Science advances · 2025Review
- The duplication of genomes and genetic networks and its potential for evolutionary adaptation and survival during environmental turmoil.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Modeling aging and its impact on cellular function and organismal behavior.Experimental gerontology · 2021Review
- A synthetic circuit for buffering gene dosage variation between individual mammalian cells.Nature communications · 2021Article
- High-resolution studies of lysis-lysogeny decision-making in bacteriophage lambda.The Journal of biological chemistry · 2019Review
- The Systems Biology of Single-Cell Aging.iScience · 2018Review
- Multi-component gene network design as a survival strategy in diverse environments.BMC systems biology · 2018Article
- Coupling of DNA Replication and Negative Feedback Controls Gene Expression for Cell-Fate Decisions.iScience · 2018Article
- Noise reduction as an emergent property of single-cell aging.Nature communications · 2017Article
- Noise reduction facilitated by dosage compensation in gene networks.Nature communications · 2016Article
- A cell size- and cell cycle-aware stochastic model for predicting time-dynamic gene network activity in individual cells.BMC systems biology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlobal noise in gene expression and chromosome duplication during cell-cycle progression cause inevitable fluctuations in the effective number of copies of gene networks in cells. These indirect and direct alterations of network copy numbers have the potential to change the output or activity of a gene network. For networks whose specific activity levels are crucial for optimally maintaining cellular functions, cells need to implement mechanisms to robustly compensate the effects of network dosage fluctuations.
resultsHere, we determine the necessary conditions for generalized N-component gene networks to be network-dosage compensated and show that the compensation mechanism can robustly operate over large ranges of gene expression levels. Furthermore, we show that the conditions that are necessary for network-dosage compensation are also sufficient. Finally, using genome-wide protein-DNA and protein-protein interaction data, we search the yeast genome for the abundance of specific dosage-compensation motifs and show that a substantial percentage of the natural networks identified contain at least one dosage-compensation motif.
conclusionsOur results strengthen the hypothesis that the special network topologies that are necessary for network-dosage compensation may be recurrent network motifs in eukaryotic genomes and therefore may be an important design principle in gene network assembly in cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.