ArticleNeuromolecular medicine2014
HIF-1α genetic variants and protein expression confer the susceptibility and prognosis of gliomas.
Article in Neuromolecular medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Serum apelin levels and cardiovascular diseases.Northern clinics of Istanbul · 2022Review
- Association of the hypoxia-inducible factor-1α (HIF-1α) gene polymorphisms with prognosis in ovarian clear cell carcinoma.Journal of ovarian research · 2019Article
- Observational
- Article
- Ruta graveolens L. induces death of glioblastoma cells and neural progenitors, but not of neurons, via ERK 1/2 and AKT activation.PloS one · 2015Article
- Clinical and prognostic significance of HIF-1α in glioma patients: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Article
- Tumor PHD2 expression is correlated with clinical features and prognosis of patients with HCC receiving liver resection.Medicine · 2014Article
- OPN Polymorphism Is Related to the Chemotherapy Response and Prognosis in Advanced NSCLC.International journal of genomics · 2014Article
- Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the role of HIF-1α genetic polymorphism of c.1772C>T and c.1790G>A in the incidence and prognosis of gliomas in a Chinese cohort, a total of 387 gliomas patients and 437 age- and sex-matched healthy controls were recruited. The genetic polymorphism of c.1772C>T and c.1790G>A was determined. We found that the genotype distribution at c.1772C>T showed significant difference between patients and controls. Multivariable analyses showed a significantly higher risk for gliomas in 1772TT genotype carriers (odds ratio 2.68, with CC as reference). In addition, we also found a significantly higher risk for grade III + IV gliomas was observed in 1772TT genotype carriers (odds ratio 2.21, with CC as reference). The overall survival rates in patients with 1772TT or 1772CT genotype were markedly lower compared with patients with CC (both P < 0.01). Our in vitro studies revealed that HIF-1α regulates the proliferation, migration and invasion of human glioma U251 cells. This study suggests that the c.1772C>T polymorphisms may be used as a molecular marker for gliomas occurrence, grades and clinical outcome in gliomas patients.
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