SynthesisTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
Association of IL-8-251A>T polymorphisms with oral cancer risk: evidences from a meta-analysis.
Synthesis in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The association between interleukin-8 gene polymorphism and the risk of sepsis in older adults.Journal of orthopaedic surgery and research · 2024Pooled it
- Association betweenMedicina (Kaunas, Lithuania) · 2021Pooled it
- Article
- Gene polymorphisms and oral cancer risk in tobacco habitués.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Association between interleukin 8-251 T/A and +781 C/T polymorphisms and glioma risk.Diagnostic pathology · 2015Article
- Chemokine function in periodontal disease and oral cavity cancer.Frontiers in immunology · 2015Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The findings of associations between interleukin-8 (IL-8) polymorphisms and risk of oral cancer are controversial. We conducted a meta-analysis on the basis of data from all published studies to provide evidence of the current understanding of the genetic association with oral cancer. Eligible studies were identified by means of an electronic search of PubMed, Elsevier, ScienceDirect, EMBASE, EBSCO, and CBM databases for studies published up to March 2013. In accordance with the inclusion and exclusion criteria, a total of six eligible studies were included in the pooled analyses. In the overall analysis, we did not observe any significant associations between the IL-8-251A>T polymorphism and oral cancer risk under any of the genetic models (all P > 0.05). In the stratified analysis by ethnicity, Caucasian individuals with genotype AA had a higher risk of oral cancer under the dominant model (OR = 1.35, 95 % CI 1.09-1.67, P = 0.006). This meta-analysis indicated that the IL-8-251A>T polymorphism was not associated with the susceptibility of oral cancer, while individuals in the Caucasian population with genotype AA had a higher risk of oral cancer under the dominant model.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.