ArticleAtherosclerosis2014
Determinants of cerebrovascular remodeling: do large brain arteries accommodate stenosis?
Article in Atherosclerosis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
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- Parent Artery Disease-Related Stroke: What Is the Impact on Endovascular Treatment? A Narrative Review.Journal of clinical medicine · 2026Review
- Epidemiology, Pathophysiology, and Medical Management of Intracranial Atherosclerotic Disease.Journal of neuroendovascular therapy · 2026Review
- Accurate and fully automated diameter measurements of Circle of Willis arteries on MRA imaging.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- Intracranial atherosclerotic disease and neurodegeneration: a narrative review and plausible mechanisms.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2024Review
- Global intracranial arterial tortuosity is associated with intracranial atherosclerotic burden.Scientific reports · 2024Article
- Focused Update on Intracranial Atherosclerosis: Introduction, Highlights, and Knowledge Gaps.Stroke · 2024Review
- Review
- Cerebral artery and brain pathology correlates of antemortem cerebral artery 4D flow MRI.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Patterns and implications of artery remodeling based on high-resolution vessel wall imaging in symptomatic severe basilar artery stenosis.Quantitative imaging in medicine and surgery · 2023Article
- Dolichoectasia: a brain arterial disease with an elusive treatment.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Determinants and Outcomes of Asymptomatic Intracranial Atherosclerotic Stenosis.Journal of the American College of Cardiology · 2021 · on this mapArticle
- Prevalence and Clinical Correlates of Intracranial Dolichoectasia in Individuals With Ischemic Stroke.Stroke · 2021Article
- Genetic and Environmental Contributions to Variation in the Posterior Communicating Collaterals of the Circle of Willis.Translational stroke research · 2019Article
- Article
- Brain vascular intima vulnerability among HIV-positive and negative individuals.AIDS (London, England) · 2018Article
- Correlation of Adventitial Vasa Vasorum with Intracranial Atherosclerosis: A Postmortem Study.Journal of stroke · 2018Article
- Histopathological Differences Between the Anterior and Posterior Brain Arteries as a Function of Aging.Stroke · 2017Article
- Systemic Atherosclerosis Relate to Brain Arterial Diameters: The Northern Manhattan Study.Cerebrovascular diseases (Basel, Switzerland) · 2017Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveIt is hypothesized that outward remodeling in systemic arteries is a compensatory mechanism for lumen area preservation in the face of increasing arterial stenosis. Large brain arteries have also been studied, but it remains unproven if all assumptions about arterial remodeling can be replicated in the cerebral circulation.
methodsThe sample included 196 autopsied subjects with a mean age of 55 years; 63 % were men, and 74 % non-Hispanic whites. From each of 1396 dissected cadaveric large arteries of the circle of Willis, the areas of the lumen, intima, media, and adventitia were measured. Internal elastic lamina (IEL) area was defined as the area encircled by this layer. Stenosis was calculated by dividing the plaque area by the IEL area and multiplying by 100.
resultsPlotting stenosis against lumen area or stratified by arterial size showed no preservation of the lumen in the setting of growing stenosis. We could not find an association between greater IEL proportion and stenosis (B = 0.44, P = 0.86). Stratifying arteries by their size, we found that smaller arteries have greater lumen reduction at any degree of stenosis (B = -23.65, P ≤ 0.0001), and although larger arteries show a positive association between IEL proportion and stenosis, this was no longer significant after adjusting for covariates (B = 6.0, P = 0.13).
conclusionsWe cannot confirm the hypothesis that large brain arteries undergo outward remodeling as an adaptive response to increasing degrees of stenosis. We found that the lumen decreases proportionally to the degree of stenosis.
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Registered trials
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