ArticleExperimental eye research2014
BAC-EDTA transepithelial riboflavin-UVA crosslinking has greater biomechanical stiffening effect than standard epithelium-off in rabbit corneas.
Article in Experimental eye research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Transepithelial corneal cross-linking: a review.International ophthalmology · 2026Review
- Riboflavin-UV crosslinking of the cornea: Wound healing and biomechanics.Experimental eye research · 2025Review
- In Vivo Femtosecond Laser Machined Transepithelial Nonlinear Optical Corneal Crosslinking Compared to Ultraviolet Corneal Crosslinking.Translational vision science & technology · 2024Article
- A review of the epithelial and stromal effects of corneal collagen crosslinking.The ocular surface · 2023Review
- Recent advances in medicinal compounds related to corneal crosslinking.Frontiers in pharmacology · 2023Review
- Evaluation of effects of riboflavin and/or ultraviolet-A on survival of rat limbal epithelial stem cells inIndian journal of ophthalmology · 2023Article
- Ovalbumin-Induced Allergic Inflammation Diminishes Cross-Linked Collagen Structures in an Experimental Rabbit Model of Corneal Cross-Linking.Frontiers in medicine · 2022Article
- Compressional Optical Coherence Elastography of the Cornea.Photonics · 2021Article
- Current perspectives on corneal collagen crosslinking (CXL).Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018Review
- Quantifying the effects of hydration on corneal stiffness with noncontact optical coherence elastography.Journal of cataract and refractive surgery · 2018Article
- Outcomes of iontophoretic corneal collagen crosslinking in keratoconic eyes with very thin corneas.Medicine · 2017Article
- Optical coherence elastography for evaluating customized riboflavin/UV-A corneal collagen crosslinking.Journal of biomedical optics · 2017Article
- Optical coherence elastography - OCT at work in tissue biomechanics [Invited].Biomedical optics express · 2017Review
- Corneal Cross-Linking with Riboflavin and UV-A in the Mouse Cornea in Vivo: Morphological, Biochemical, and Physiological Analysis.Translational vision science & technology · 2017Article
- Evaluating the Effects of Riboflavin/UV-A and Rose-Bengal/Green Light Cross-Linking of the Rabbit Cornea by Noncontact Optical Coherence Elastography.Investigative ophthalmology & visual science · 2016Article
- Collagen cross-linking: when and how? A review of the state of the art of the technique and new perspectives.Eye and vision (London, England) · 2015Review
- Comparison of ocular discomfort after three different epithelial debridement techniques for corneal collagen cross-linking in keratoconus treatment.Therapeutic advances in ophthalmologyArticle
- Noncontact Elastic Wave Imaging Optical Coherence Elastography for Evaluating Changes in Corneal Elasticity Due to Crosslinking.IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics SocietyArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Studies suggest that standard corneal collagen crosslinking (CXL) is a safe and effective treatment to stiffen the cornea for keratoconus and other ectatic corneal disorders. The purpose of the present study was to compare the biomechanical effects of transepithelial benzalkonium chloride-EDTA (BAC-EDTA) riboflavin-UVA crosslinking to standard epithelium-off riboflavin-UVA crosslinking in a rabbit model. Corneal stiffness was quantified using optical coherence elastography at two months after treatment. The mean lateral-to-axial displacement ratio for the BAC-EDTA transepithelial CXL group was lower (greater stiffness) [0.062 ± 0.042, mean ± SD] than epithelium-off CXL (mean ± SD: 0.065 ± 0.045) or untreated control eyes (0.069 ± 0.044). Using ANOVA with Tukey correction, a statistically significant difference was found between the BAC-EDTA transepithelial CXL group and standard epithelium-off CXL (p = 0.0019) or the untreated control (p < 0.0001) groups. A graph of the probability density functions for biomechanical stiffness also showed a greater shift in stiffening in the BAC-EDTA transepithelial CXL group than the standard epithelium-off CXL or untreated control group. These results demonstrated that the biomechanical stiffening effect produced by BAC-EDTA transepithelial CXL was greater than that produced by standard epithelium-off CXL in a rabbit model.
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