ArticleBrain, behavior, and immunity2014
Kinetic characteristics of euflammation: the induction of controlled inflammation without overt sickness behavior.
Article in Brain, behavior, and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Neuroinflammation strokes the brain: A double-edged sword in ischemic stroke.Neural regeneration research · 2026Article
- Redox Regulation of the NLRP3 Inflammasome and its Implications for Immunization-related Neuroinflammation.Molecular neurobiology · 2026Review
- Pretreatment with the psychedelic DOI mitigates LPS-induced hippocampal inflammation and behavioral impairments in mice.BMC neuroscience · 2026Article
- Converged avenues: depression and Alzheimer's disease- shared pathophysiology and novel therapeutics.Molecular biology reports · 2024Review
- Viewpoint: Is lipopolysaccharide a hormone or a vitamin?Brain, behavior, and immunity · 2023Review
- Liposaccharide-induced sustained mild inflammation fragments social behavior and alters basolateral amygdala activity.Psychopharmacology · 2023Article
- Leukotrienes vs. Montelukast-Activity, Metabolism, and Toxicity Hints for Repurposing.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Environmental pollutant exposure can exacerbate COVID-19 neurologic symptoms.Medical hypotheses · 2020Article
- Immunoneuropsychiatry - novel perspectives on brain disorders.Nature reviews. Neurology · 2019Review
- Mammary tumor and mastectomy synergistically promote neuroinflammation in a breast cancer survivor model.Brain research · 2019Article
- Inflammatory Response in the CNS: Friend or Foe?Molecular neurobiology · 2017Review
- Euflammation Attenuates Central and Peripheral Inflammation and Cognitive Consequences of an Immune Challenge after Tumor Development.Neuroimmunomodulation · 2017Article
- Neuroinflammation and Infection: Molecular Mechanisms Associated with Dysfunction of Neurovascular Unit.Frontiers in cellular and infection microbiology · 2017Review
- Neuroinflammation: the devil is in the details.Journal of neurochemistry · 2016Review
- Euflammation attenuates peripheral inflammation-induced neuroinflammation and mitigates immune-to-brain signaling.Brain, behavior, and immunity · 2016Article
- Review
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Authors and funding
4 authors.
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Abstract
We found recently that controlled progressive challenge with subthreshold levels of E. coli can confer progressively stronger resistance to future reinfection-induced sickness behavior to the host. We have termed this type of inflammation "euflammation". In this study, we further characterized the kinetic changes in the behavior, immunological, and neuroendocrine aspects of euflammation. Results show euflammatory animals only display transient and subtle sickness behaviors of anorexia, adipsia, and anhedonia upon a later infectious challenge which would have caused much more severe and longer lasting sickness behavior if given without prior euflammatory challenges. Similarly, infectious challenge-induced corticosterone secretion was greatly ameliorated in euflammatory animals. At the site of E.coli priming injections, which we termed euflammation induction locus (EIL), innate immune cells displayed a partial endotoxin tolerant phenotype with reduced expression of innate activation markers and muted inflammatory cytokine expression upon ex vivo LPS stimulation, whereas innate immune cells outside EIL displayed largely opposite characteristics. Bacterial clearance function, however, was enhanced both inside and outside EIL. Finally, sickness induction by an infectious challenge placed outside the EIL was also abrogated. These results suggest euflammation could be used as an efficient method to "train" the innate immune system to resist the consequences of future infectious/inflammatory challenges.
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