ArticleThe Libyan journal of medicine2014
Oxidative stress and lung function profiles of male smokers free from COPD compared to those with COPD: a case-control study.
Article in The Libyan journal of medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Nutrition as a modifiable factor in the onset and progression of pulmonary function impairment in COPD: a systematic review.Nutrition reviews · 2022Pooled it
- Systematic Review of Physical Activity, Sedentary Behaviour and Sleep Among Adults Living with Chronic Respiratory Disease in Low- and Middle-Income Countries.International journal of chronic obstructive pulmonary disease · 2022Pooled it
- Exhaled nitric oxide in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis.International journal of chronic obstructive pulmonary disease · 2018Pooled it
- Circulating biomarkers of oxidative stress in chronic obstructive pulmonary disease: a systematic review.Respiratory research · 2016Pooled it
- Impact of the Tobacco-Smoking Status on the Phagocyte-Derived Generation of Reactive Oxygen Species: New Modification of the Whole-Blood Chemiluminescence Assay.Luminescence : the journal of biological and chemical luminescence · 2026Article
- Right Ventricular Strain and Left Ventricular Strain Using Speckle Tracking Echocardiography-Independent Prognostic Associations in COPD Alongside NT-proBNP.Diseases (Basel, Switzerland) · 2025Article
- Impact of smoking on redox homeostasis and 8-OHdG levels in COPD patients: a cross-sectional comparative study.BMC pulmonary medicine · 2025Article
- Reactive Oxygen Species and Antioxidative Defense in Chronic Obstructive Pulmonary Disease.Antioxidants (Basel, Switzerland) · 2021Review
- Reliability and Usefulness of Different Biomarkers of Oxidative Stress in Chronic Obstructive Pulmonary Disease.Oxidative medicine and cellular longevity · 2020Review
- Total Antioxidant Status in Stable Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2020Article
- Cell-free hemoglobin promotes primary graft dysfunction through oxidative lung endothelial injury.JCI insight · 2018Article
- Abdominal adiposity intensifies the negative effects of ambient air pollution on lung function in Korean men.International journal of obesity (2005) · 2017Article
- Are healthy smokers really healthy?Tobacco induced diseases · 2016Review
- Redox Changes Induced by General Anesthesia in Critically Ill Patients with Multiple Traumas.Molecular biology international · 2015Review
- Defining obstructive ventilatory defect in 2015.The Libyan journal of medicine · 2015Article
- Oxidative stress and free radicals in COPD--implications and relevance for treatment.International journal of chronic obstructive pulmonary disease · 2014Review
- How to Stage Airflow Limitation in Stable Chronic Obstructive Pulmonary Disease Male Patients?American journal of men's healthArticle
- The Impacts of Ramadan Intermittent Fasting on Oxidant/Antioxidant Stress Biomarkers of Stable Chronic Obstructive Pulmonary Disease Male Patients.American journal of men's healthArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe mechanisms of smoking tobacco leading to chronic obstructive pulmonary disease (COPD) are beginning to be understood. However, conclusions about the role of blood or lung oxidative stress markers were disparate.
aimsTo investigate the oxidative stress in blood or lung associated with tobacco smoke and to evaluate its effect on pulmonary function data and its relation with physical activity.
methodsIt is a case-control study. Fifty-four male-smokers of more than five pack-years (PY) and aged 40-60 years were included (29 Non-COPD, 16 COPD). Physical activity score was determined. Blood sample levels of malondialdehyde (MDA), protein-cys-SH (PSH), and Glutathione (GSH) were measured. Fractional exhaled nitric oxide (FeNO) and plethysmographic measurements were performed. Correlation coefficients (r) evaluated the association between oxidative stress markers and independent variables (plethysmographic data and physical activity score).
resultsNon-COPD (48 ± 6 years) and COPD (49 ± 5 years) groups had similar tobacco consumption patterns, that is, 27 ± 14 PY versus 30 ± 19 PY, respectively. Compared to the Non-COPD group, the COPD group had significantly lower levels of GSH and PSH, that is, mean ± SE were 40 ± 6 versus 25 ± 5 µg/mL and 54 ± 10 versus 26 ± 5 µg/g of hemoglobin, respectively. However, MDA level and FeNO values were similar. In the COPD group, none of the oxidative stress markers was significantly correlated with plethysmographic data or physical activity score. In the Non-COPD group, GSH was significantly correlated with physical activity score (r = 0.47) and PSH was significantly correlated with total lung capacity (TLC) (r = -0.50), residual volume (r = 0.41), and physical activity score (r = 0.62). FeNO was significantly correlated with TLC of the COPD group (r = -0.48).
conclusionCompared to the Non-COPD group, the COPD group had a marked decrease in blood antioxidant markers (GSH and PSH) but similar blood oxidant (MDA) or lung (FeNO) burden.
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