ArticleBrain research2014
Role of medial prefrontal and orbitofrontal monoamine transporters and receptors in performance in an adjusting delay discounting procedure.
Article in Brain research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Dopaminergic modulation of reward discounting in healthy rats: a systematic review and meta-analysis.Psychopharmacology · 2021Pooled it
- The effects of prelimbic inhibition on time-based intervention and impulsive choice.Behavioural brain research · 2027Article
- Optogenetic inhibition reveals distinct contributions of medial prefrontal cortex to intertemporal choice in young and aged rats.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Revisiting the Role of Serotonin in Attention-Deficit Hyperactivity Disorder: New Insights from Preclinical and Clinical Studies.Clinical drug investigation · 2025Review
- Dopaminergic modulation of sensitivity to immediate and delayed punishment during decision-making.Cognitive, affective & behavioral neuroscience · 2024Article
- Reduced serotonergic transmission alters sensitivity to cost and reward via 5-HT1A and 5-HT1B receptors in monkeys.PLoS biology · 2024Article
- Relationship between two forms of impulsivity in mice at baseline and under acute and sub-chronic atomoxetine treatment.Progress in neuro-psychopharmacology & biological psychiatry · 2023Article
- Selective chemogenetic inactivation of corticoaccumbal projections disrupts trait choice impulsivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Rejecting impulsivity as a psychological construct: A theoretical, empirical, and sociocultural argument.Psychological review · 2021Article
- Effects of d-amphetamine and MK-801 on impulsive choice: Modulation by schedule of reinforcement and delay length.Behavioural brain research · 2019Article
- The effect of 5-HTThe journal of physiological sciences : JPS · 2019Article
- The use of laser capture microdissection to identify specific pathways and mechanisms involved in impulsive choice in rats.Heliyon · 2019Article
- Optogenetic dissection of basolateral amygdala contributions to intertemporal choice in young and aged rats.eLife · 2019Article
- Juvenile exposure to methylphenidate and guanfacine in rats: effects on early delay discounting and later cocaine-taking behavior.Psychopharmacology · 2019Article
- Brain and Cognition for Addiction Medicine: From Prevention to Recovery Neural Substrates for Treatment of Psychostimulant-Induced Cognitive Deficits.Frontiers in psychiatry · 2019Review
- Executive (dys)function after stroke: special considerations for behavioral pharmacology.Behavioural pharmacology · 2018Review
- 5-HTPsychopharmacology · 2018Article
- Contributions of medial prefrontal cortex to decision making involving risk of punishment.Neuropharmacology · 2018Article
- Enhanced dopamine D2 autoreceptor function in the adult prefrontal cortex contributes to dopamine hypoactivity following adolescent social stress.The European journal of neuroscience · 2018Article
- Dissecting drug effects in preclinical models of impulsive choice: emphasis on glutamatergic compounds.Psychopharmacology · 2018Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Performance in an adjusting delay discounting procedure is predictive of drug abuse vulnerability; however, the shared underlying specific prefrontal neural systems linking delay discounting and increased addiction-like behaviors are unclear. Rats received direct infusions of methylphenidate (MPH; 6.25, 25.0, or 100μg), amphetamine (AMPH; 0.25, 1.0, or 4.0μg), or atomoxetine (ATO; 1.0, 4.0, or 16.0μg) into either medial prefrontal cortex (mPFC) or orbitofrontal cortex (OFC) immediately prior to performance in an adjusting delay task. These drugs were examined because they are efficacious in treating impulse control disorders. Because dopamine (DA) and serotonin (5-HT) receptors are implicated in impulsive behavior, separate groups of rats received microinfusions of the DA receptor-selective drugs SKF 81297 (0.1 or 0.4µg), SCH 23390 (0.25 or 1.0µg), quinpirole (1.25 or 5.0µg), and eticlopride (0.25 or 1.0µg), or received microinfusions of the 5-HT receptor-selective drugs 8-OH-DPAT (0.025 or 0.1μg), WAY 100635 (0.01 or 0.04μg), DOI (2.5 or 10.0μg), and ketanserin (0.1 or 0.4μg). Impulsive choice was not altered significantly by MPH, AMPH, or ATO into either mPFC or OFC, indicating that neither of these prefrontal regions alone may mediate the systemic effect of ADHD medications on impulsive choice. However, quinpriole (1.25μg) and eticlopride infused into mPFC increased impulsive choice, whereas 8-OH-DPAT infused into OFC decreased impulsive choice. These latter results demonstrate that blockade of DA D2 receptors in mPFC or activation of 5-HT1A receptors in OFC increases impulsive choice in the adjusting delay procedure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.