ArticleBiology open2014
Shape and position of the node and notochord along the bilateral plane of symmetry are regulated by cell-extracellular matrix interactions.
Article in Biology open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Mesodermal fibronectin controls cell shape, polarity, and mechanotransduction in the second heart field during cardiac outflow tract development.Developmental cell · 2025Article
- Article
- Cell-Extracellular Matrix Interactions Play Multiple Essential Roles in Aortic Arch Development.Circulation research · 2021Article
- Protein phosphatase 1 regulatory subunit 35 is required for ciliogenesis, notochord morphogenesis, and cell-cycle progression during murine development.Developmental biology · 2020Article
- Systems Analysis of Biliary Atresia Through Integration of High-Throughput Biological Data.Frontiers in physiology · 2020Article
- The role of integrins inDevelopment (Cambridge, England) · 2019Article
- Photo-patterned oxygen sensing films based on Pt porphyrin for controlling cell growth and studying metabolism.RSC advances · 2019Article
- Demystification of animal symmetry: symmetry is a response to mechanical forces.Biology direct · 2017Article
- Cilia in vertebrate left-right patterning.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Notochord morphogenesis in mice: Current understanding & open questions.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Review
- A high-content platform to characterise human induced pluripotent stem cell lines.Methods (San Diego, Calif.) · 2016Article
- Neural crest cell-autonomous roles of fibronectin in cardiovascular development.Development (Cambridge, England) · 2016Article
- Fibronectin signals through integrin α5β1 to regulate cardiovascular development in a cell type-specific manner.Developmental biology · 2015Article
- Mesodermal expression of integrin α5β1 regulates neural crest development and cardiovascular morphogenesis.Developmental biology · 2014Article
- Mechanisms of left-right asymmetry and patterning: driver, mediator and responder.F1000prime reports · 2014Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The node and notochord (and their equivalents in other species) are essential signaling centers, positioned along the plane of bilateral symmetry in developing vertebrate embryos. However, genes and mechanisms regulating morphogenesis of these structures and their placement along the embryonic midline are not well understood. In this work, we provide the first evidence that the position of the node and the notochord along the bilateral plane of symmetry are under genetic control and are regulated by integrin α5β1 and fibronectin in mice. We found that the shape of the node is often inverted in integrin α5-null and fibronectin-null mutants, and that the positioning of node and the notochord is often skewed away from the perceived plane of embryonic bilateral of symmetry. Our studies also show that the shape and position of the notochord are dependent on the shape and embryonic placement of the node. Our studies suggest that fibronectin regulates the shape of the node by affecting apico-basal polarity of the nodal cells. Taken together, our data indicate that cell-extracellular matrix interactions mediated by integrin α5β1 and fibronectin regulate the geometry of the node as well as the placement of the node and notochord along the plane of bilateral symmetry in the mammalian embryo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.