ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2015
Effect of open wedge high tibial osteotomy on the lateral tibiofemoral compartment in sheep. Part III: analysis of the microstructure of the subchondral bone and correlations with the articular cartilage and meniscus.
Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Residual coronary malformation after tibial shaft fracture alters the contact status of the meniscus and cartilage in the knee joint: a computational study.Frontiers in surgery · 2024Article
- Fixation method can affect posterior tibial slope in opening-wedge high tibial osteotomy: a retrospective study.Journal of orthopaedic surgery and research · 2023Article
- Discharging the medial knee compartment: comparison of pressure distribution and kinematic shifting after implantation of an extra-capsular absorber system (ATLAS) and open-wedge high tibial osteotomy-a biomechanical in vitro analysis.Archives of orthopaedic and trauma surgery · 2023Article
- High tibial osteotomy to neutral alignment improves medial knee articular cartilage composition.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022Article
- A high-resolution cross-species comparative analysis of the subchondral bone provides insight into critical topographical patterns of the osteochondral unit.Clinical and translational medicine · 2022Article
- The Effect of Body Mass Index and Metformin on Matrix Gene Expression in Arthritic Primary Human Chondrocytes.Cartilage · 2021Article
- [Relevance of meniscus loss for the progression of osteoarthritis and treatment options for early arthritis].Der Orthopade · 2021Review
- Advances in modern osteotomies around the knee : Report on the Association of Sports Traumatology, Arthroscopy, Orthopaedic surgery, Rehabilitation (ASTAOR) Moscow International Osteotomy Congress 2017.Journal of experimental orthopaedics · 2019Review
- Improved clinical outcome after medial open-wedge osteotomy despite cartilage lesions in the lateral compartment.PloS one · 2019Article
- Meniscal pathologies on MRI correlate with increased bone tracer uptake in SPECT/CT.European radiology · 2018Article
- Longitudinal changes in subchondral bone structure as assessed with MRI are associated with functional outcome after high tibial osteotomy.Journal of ISAKOS : joint disorders & orthopaedic sports medicine · 2018Article
- High tibial osteotomy accelerates lateral compartment osteoarthritis in discoid meniscus patients.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2018Article
- Large correction in opening wedge high tibial osteotomy with resultant joint-line obliquity induces excessive shear stress on the articular cartilage.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2018Article
- Comparison of the efficiency of an extra-articular absorber system and high tibial osteotomy for unloading the medial knee compartment: an in vitro study.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2017Article
- Progression of medial compartmental osteoarthritis 2-8 years after lateral closing-wedge high tibial osteotomy.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2017Article
- [Meniscal lesion. A pre-osteoarthritic condition of the knee joint].Der Orthopade · 2017Review
- Factors affecting cartilage repair after medial opening-wedge high tibial osteotomy.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2017Article
- Osteotomy configuration of the proximal wedge and analysis of the affecting factors in the medial open-wedge high tibial osteotomy.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2017Article
- Is overcorrection preferable for repair of degenerated articular cartilage after open-wedge high tibial osteotomy?Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2017Article
- The role of meniscal tissue in joint protection in early osteoarthritis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2016Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeFirst, to evaluate whether medial open wedge high tibial osteotomy (HTO) induces alterations of the microstructure of the lateral tibial subchondral bone plate of sheep. Second, to test the hypothesis that specific correlations exist between topographical structural alterations of the subchondral bone, the cartilage and the lateral meniscus.
methodsThree experimental groups received biplanar osteotomies of the right proximal tibiae: (a) closing wedge HTO (4.5° of tibial varus), (b) opening wedge HTO (4.5° tibial valgus; standard correction) and (c) opening wedge HTO (9.5° of valgus; overcorrection), each of which was compared to the non-osteotomised contralateral proximal tibiae. After 6 months, subchondral bone structure indices were measured by computed tomography. Correlations between the subchondral bone, the articular cartilage and the lateral meniscus were determined.
resultsIncreased loading by valgus overcorrection led to an enlarged specific bone surface (BS/BV) in the subarticular spongiosa compared with unloading by varisation. The subchondral bone plate was 3.9-fold thicker in the central region of the lateral tibial plateau than in the submeniscal periphery. Its thickness in the central region significantly correlated with the thickness of the articular cartilage. In the submeniscal region, such correlation did not exist. In general, a higher degree of osteoarthritis (OA) correlated with alterations of the subchondral bone plate microstructure. OA of the submeniscal articular cartilage also correlated with worse matrix staining of the lateral meniscus.
conclusionOsteoarthritis changes are associated with alterations of the subchondral bone plate microstructure. Specific topographical relationships exist in the central region between the articular cartilage and subchondral bone plate thickness, and in the submeniscal periphery between and the articular cartilage and lateral meniscus. From a clinical perspective, the combined follow-up data from this and the previous two investigations suggest that open wedge valgus HTO is a safe procedure for the lateral compartment to manage medial osteoarthritis of the knee with varus malalignment in the short term.
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