ArticleMicrobiology (Reading, England)2014
The lone S41 family C-terminal processing protease in Staphylococcus aureus is localized to the cell wall and contributes to virulence.
Article in Microbiology (Reading, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 35 citations in OpenAlex.
- Tail-specific protease is an essentialInfection and immunity · 2024Article
- Genome-wide association study for yield-related traits in faba bean (Frontiers in plant science · 2024Article
- Evolution and Role of Proteases inBiomolecules · 2023Review
- The identification of two M20B family peptidases required for full virulence inFrontiers in cellular and infection microbiology · 2023Article
- In Silico Genome-Scale Analysis of Molecular Mechanisms Contributing to the Development of a Persistent Infection with Methicillin-ResistantInternational journal of molecular sciences · 2022Article
- Genomic Insights into the Distribution of Peptidases and Proteolytic Capacity amongMicrobiology spectrum · 2022Article
- Bacterial Carboxyl-Terminal Processing Proteases Play Critical Roles in the Cell Envelope and Beyond.Journal of bacteriology · 2022Review
- Article
- Temperature Influences the Composition and Cytotoxicity of Extracellular Vesicles in Staphylococcus aureus.mSphere · 2021Article
- Carboxy-Terminal Processing Protease Controls Production of Outer Membrane Vesicles and Biofilm inMicroorganisms · 2021Article
- The Tail-Specific Protease Is Important for Legionella pneumophila To Survive Thermal Stress in Water and inside Amoebae.Applied and environmental microbiology · 2021Article
- Article
- Mutation of the Carboxy-Terminal Processing Protease inPathogens (Basel, Switzerland) · 2020Article
- SosA inhibits cell division in Staphylococcus aureus in response to DNA damage.Molecular microbiology · 2019Article
- Patterns of inter- and intrasubspecific homologous recombination inform eco-evolutionary dynamics of Xylella fastidiosa.The ISME journal · 2019Article
- Article
- A Small RNA Transforms the Multidrug Resistance of Pseudomonas aeruginosa to Drug Susceptibility.Molecular therapy. Nucleic acids · 2019Article
- An unconventional RNA-based thermosensor within the 5' UTR of Staphylococcus aureus cidA.PloS one · 2019Article
- Detailed Soluble Proteome Analyses of a Dairy-IsolatedFrontiers in nutrition · 2019Article
- The Intracellular Cyclophilin PpiB Contributes to the Virulence of Staphylococcus aureus Independently of Its Peptidyl-ProlylInfection and immunity · 2018Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Staphylococcus aureus is a versatile pathogen of humans and a continued public health concern due to the rise and spread of multidrug-resistant strains. As part of an ongoing investigation into the pathogenic mechanisms of this organism we previously demonstrated that an intracellular N-terminal processing protease is required for S. aureus virulence. Following on from this, here we examine the role of CtpA, the lone C-terminal processing protease of S. aureus. CtpA, a member of the S41 family, is a serine protease whose homologues in Gram-negative bacteria have been implicated in a range of biological functions, including pathogenesis. We demonstrate that S. aureus CtpA is localized to the bacterial cell wall and expression of the ctpA gene is maximal upon exposure to conditions encountered during infection. Disruption of the ctpA gene leads to decreased heat tolerance and increased sensitivity when exposed to components of the host immune system. Finally we demonstrate that the ctpA(-) mutant strain is attenuated for virulence in a murine model of infection. Our results represent the first characterization of a C-terminal processing protease in a pathogenic Gram-positive bacterium and show that it plays a critical role during infection.
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