ArticleArthritis research & therapy2014
Elevated C-reactive protein is associated with lower increase in knee muscle strength in patients with knee osteoarthritis: a 2-year follow-up study in the Amsterdam Osteoarthritis (AMS-OA) cohort.
Article in Arthritis research & therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Meta-analysis of serum C-reactive protein and cartilage oligomeric matrix protein levels as biomarkers for clinical knee osteoarthritis.BMC musculoskeletal disorders · 2018Pooled it
- Trial
- Effects of a Mediterranean Diet Compared with the Low-Fat Diet on Patients with Knee Osteoarthritis: A Randomized Feeding Trial.International journal of clinical practice · 2022Trial
- Association between traditional Chinese Medicine and osteoarthritis outcome: A 5-year matched cohort study.Heliyon · 2024Article
- Metabolic syndrome increases osteoarthritis risk: findings from the UK Biobank prospective cohort study.BMC public health · 2024Article
- Monomeric C reactive protein (mCRP) regulates inflammatory responses in human and mouse chondrocytes.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- Diagnostic criteria for early hip osteoarthritis: first steps, based on the CHECK study.Rheumatology (Oxford, England) · 2021Article
- Towards developing diagnostic criteria for early knee osteoarthritis: data from the CHECK study.Rheumatology (Oxford, England) · 2021Article
- A Next Generation Formulation of Curcumin Ameliorates Experimentally Induced Osteoarthritis in RatsFrontiers in immunology · 2021Article
- Comparison of Postoperative Effects between Medial Pivot Prosthesis and Posterior Stabilized Prosthesis.Orthopaedic surgery · 2020Article
- Course and predictors of upper leg muscle strength over 48 months in subjects with knee osteoarthritis: Data from the osteoarthritis initiative.Osteoarthritis and cartilage open · 2020Article
- Quadriceps Weakness in Individuals with Coexisting Medial and Lateral Osteoarthritis.JB & JS open access · 2019Article
- Article
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Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe aim of this study was to examine the associations of elevated serum C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) with change in muscle strength in patients with established knee osteoarthritis (OA), at 2 years.
methodsData from 186 patients with knee OA were gathered at baseline and at 2-year follow-up. CRP (in milligrams per liter) and ESR (in millimeters per hour) were measured in serum from patients' blood. Strength of quadriceps and hamstrings muscles was assessed by using an isokinetic dynamometer. The association of inflammatory markers with change in knee muscle strength was analyzed by using uni- and multi-variate linear regression models.
resultsPatients with elevated CRP values at both baseline and 2-year follow-up exhibited a lower increase in knee muscle strength for a period of 2 years (β = -0.22; P = 0.01) compared with the group with non-elevated levels at both times of assessment. The association persisted after adjustment for relevant confounders. Elevated ESR values at both times of assessment were not significantly associated with change in knee muscle strength (β = -0.05; P = 0.49).
conclusionsOur results indicate that elevated CRP values are related to a lower gain in muscle strength over time in patients with established knee OA. Although the mechanism to explain this relationship is not fully elucidated, these results suggest inflammation as a relevant factor influencing muscle strength in this group of patients.
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