SynthesisClinical infectious diseases : an official publication of the Infectious Diseases Society of America2014
Vertical transmission of hepatitis C virus: systematic review and meta-analysis.
Synthesis in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 192 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Vertical Transmission of Hepatitis C in Adult Children of Female Baby Boomers
An Observational Study of Mother-Infant Outcomes Following Antenatal Exposure to Direct-Acting Antivirals: the Treatment in Pregnancy for Hepatitis C ("TiP-HepC") Registry
Who cites it
192 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- FIGO guideline on liver disease and pregnancy.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Guideline
- Pooled it
- Epidemiologic profile of hepatitis C virus infection and genotype distribution in Burkina Faso: a systematic review with meta-analysis.BMC infectious diseases · 2021Pooled it
- Hepatitis C Guidance 2019 Update: American Association for the Study of Liver Diseases-Infectious Diseases Society of America Recommendations for Testing, Managing, and Treating Hepatitis C Virus Infection.Hepatology (Baltimore, Md.) · 2020Guideline
- Article
- No Risk, Severe Consequence: Hepatitis C Criminalization in Indiana Involves Only Non-Transmissible Exposures.AIDS and behavior · 2026Article
- IMPAACT 2041: Designing the Study of Glecaprevir/Pibrentasvir Treatment During Pregnancy.Open forum infectious diseases · 2026Article
- Prevalence of Hepatitis B, Hepatitis C, and HTLV-1 Using an Expanded Testing Panel Among Pregnant Women in Two Cities in Colombia, 2024-2025Revista colombiana de obstetricia y ginecologia · 2026Article
- DAAs in pregnancy are the only potential intervention to decrease vertical transmission: Pregnancy DAA data support safety.Hepatology communications · 2026Article
- Seroprevalence of hepatitis C antibodies in pregnant women in the state of Paraná, Brazil.Clinics (Sao Paulo, Brazil) · 2026Article
- Care strategies for pregnant people and women living with hepatitis C in North America.AJOG global reports · 2026Article
- Preexisting Liver Disease and Pregnancy: Optimizing Care to Optimize Outcomes.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026Review
- Joinpoint regression and age-period-cohort analyses of global and Chinese acute hepatitis C incidence trends, 1990-2021.Frontiers in public health · 2026Article
- 2025 KASL clinical practice guidelines for management of hepatitis C.Clinical and molecular hepatology · 2026Article
- Prevalence of neurodevelopmental disorders in children with chronic hepatitis C in British Columbia.Canadian liver journal · 2025Article
- Hepatitis C virus testing in infants, a move to early screening by HCV RNA at 2 months of age.Paediatrics & child health · 2025Article
- Hepatitis C virus in childhood and pregnancy.Infectious diseases & immunity · 2025Review
- Prevalence of hepatitis C virus infection in Qatar's resident population based on a national screening campaign.Scientific reports · 2025Article
- Fast pacing India's fight against viral hepatitis: Targets & action points.The Indian journal of medical research · 2025Article
- Update on Pediatric Hepatitis C Infection.Current gastroenterology reports · 2025Review
132 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe conducted a systematic review of estimates of hepatitis C virus (HCV) vertical transmission risk to update current estimates published more than a decade ago.
methodsPubMed and Embase were searched and 109 articles were included. Pooled estimates of risk were generated for children born to HCV antibody-positive and viremic women, aged ≥18 months, separately by maternal human immunodeficiency virus (HIV) coinfection.
resultsMeta-analysis of the risk of vertical HCV infection to children of HCV antibody-positive and RNA-positive women was 5.8% (95% confidence interval [CI], 4.2%-7.8%) for children of HIV-negative women and 10.8% (95% CI, 7.6%-15.2%) for children of HIV-positive women. The adjusted meta-regression model explained 51% of the between-study variation in the 25 included risk estimates. Maternal HIV coinfection was the most important determinant of vertical transmission risk (adjusted odds ratio, 2.56 [95% CI, 1.50-4.43]). Additional methodological (follow-up rate and definition of infection in children) and risk factors independently predicted HCV infection and need to be captured and reported by future studies of vertical transmission. Studies assessing the contribution of nonvertical exposures in early childhood to HCV prevalence among children at risk of vertical transmission are needed.
conclusionsMore than 1 in every 20 children delivered by HCV chronically infected women are infected, highlighting that vertical transmission likely constitutes the primary transmission route among children. These updated estimates are a basis for decision making in prioritization of research into risk-reducing measures, and inform case management in clinical settings, especially for HIV-positive women in reproductive age.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.