ArticleJournal of the American Medical Informatics Association : JAMIA
Don't fuel the fire: decreasing intravenous haloperidol use in high risk patients via a customized electronic alert.
Article in Journal of the American Medical Informatics Association : JAMIA. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- The Effect of Computerized Alerts on Prescribing and Patient Outcomes: A Systematic Review.Applied clinical informatics · 2025Pooled it
- Impact of an Alert-Based Inpatient Clinical Decision Support Tool to Prevent Drug-Induced Long QT Syndrome: Large-Scale, System-Wide Observational Study.Journal of medical Internet research · 2025Observational
- A polygenic risk score for the QT interval is an independent predictor of drug-induced QT prolongation.PloS one · 2024Article
- Interpretable Machine Learning Prediction of Drug-Induced QT Prolongation: Electronic Health Record Analysis.Journal of medical Internet research · 2022Article
- Rationale and design of the Novel Uses of adaptive Designs to Guide provider Engagement in Electronic Health Records (NUDGE-EHR) pragmatic adaptive randomized trial: a trial protocol.Implementation science : IS · 2021Article
- Assessing Prescriber Behavior with a Clinical Decision Support Tool to Prevent Drug-Induced Long QT Syndrome.Applied clinical informatics · 2021Article
- Clinician Perspectives on Electronic Health Records, Communication, and Patient Safety Across Diverse Medical Oncology Practices.Journal of oncology practice · 2019Article
- Cranky comments: detecting clinical decision support malfunctions through free-text override reasons.Journal of the American Medical Informatics Association : JAMIA · 2019Article
- Primary care provider adherence to an alert for intensification of diabetes blood pressure medications before and after the addition of a "chart closure" hard stop.Journal of the American Medical Informatics Association : JAMIA · 2018Article
- Reining in the QTc: reducing the risk of Torsades de Pointes across a major health system.Journal of the American Medical Informatics Association : JAMIA · 2018Article
- Schizophrenia: synthetic strategies and recent advances in drug design.MedChemComm · 2018Review
- Providers' Response to Clinical Decision Support for QT Prolonging Drugs.Journal of medical systems · 2017Article
- Biomedical informatics advancing the national health agenda: the AMIA 2015 year-in-review in clinical and consumer informatics.Journal of the American Medical Informatics Association : JAMIA · 2017Review
- A Survey of the Literature on Unintended Consequences Associated with Health Information Technology: 2014-2015.Yearbook of medical informatics · 2016Review
- Antipsychotic medication utilization in nonpsychiatric hospitalizations.Journal of hospital medicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Delivering useful clinical decision support to providers who are ordering high risk drugs for high risk patients is imperative for safe pharmacotherapy. This paper presents a focused electronic clinical decision support intervention designed to decrease the risk of corrected QT interval (QTc) related adverse drug events in a high risk patient population. Results showed that a customized alert can both decrease the number of alerts sent to providers while still improving the safety of prescribing practices for intravenous haloperidol. The alert leveraged components of the electronic health record to significantly decrease the rate of inappropriate prescription of intravenous haloperidol in patients with QTc >500 ms from 50% to 14%. The results also suggest providers may abandon the appropriate prescription of a medication in response to an alert. The findings support the necessity of careful targeting of electronic alerts and monitoring for unintended consequences when implementing these types of electronic alerts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.