ArticleJournal of assisted reproduction and genetics2014
Efficacy of ovarian tissue cryopreservation in a major European center.
Article in Journal of assisted reproduction and genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Comparison of the quality of ovarian tissue cryopreservation by conventional slow cryopreservation and vitrification-a systematic review and meta-analysis.Journal of ovarian research · 2025Pooled it
- A Systematic Review of Ovarian Tissue Transplantation Outcomes by Ovarian Tissue Processing Size for Cryopreservation.Frontiers in endocrinology · 2022Pooled it
- New advances in ovarian autotransplantation to restore fertility in cancer patients.Cancer metastasis reviews · 2015Pooled it
- Functional Tissue Analysis Reveals Successful Cryopreservation of Human Osteoarthritic Synovium.PloS one · 2016Trial
- Revascularization of human ovarian cortical grafts is not equally efficient from both sides of the cortex tissue.Frontiers in endocrinology · 2025Article
- Gene expression analysis of ovarian follicles and stromal cells in girls with Turner syndrome.Molecular human reproduction · 2024Article
- Evaluating the safety and efficacy of cryopreserved ovarian tissue transplantation in leukemia patients with different bone marrow remission status using xenotransplantation.Frontiers in endocrinology · 2024Article
- Comparative effects of a calcium chelator (BAPTA-AM) and melatonin on cryopreservation-induced oxidative stress and damage in ovarian tissue.Scientific reports · 2023Article
- Nanowarming improves survival of vitrified ovarian tissue and follicular development in a sheep model.Heliyon · 2023Article
- Effects of hypoxia-preconditioned HucMSCs on neovascularization and follicle survival in frozen/thawed human ovarian cortex transplanted to immunodeficient mice.Stem cell research & therapy · 2022Article
- High cryo-resistance of SARS-CoV-2 virus: Increased risk of re-contamination at transplantation of cryopreserved ovarian tissue after COVID-19 pandemic.Cryobiology · 2021Review
- Concept Paper on the Technique of Cryopreservation, Removal and Transplantation of Ovarian Tissue for Fertility Preservation.Geburtshilfe und Frauenheilkunde · 2019Article
- Structure of preantral follicles, oxidative status and developmental competence of in vitro matured oocytes after ovary storage at 4 °C in the domestic cat model.Reproductive biology and endocrinology : RB&E · 2018Article
- A transportation network for human ovarian tissue is indispensable to success for fertility preservation.Journal of assisted reproduction and genetics · 2017Review
- Complete protection against cryodamage of cryopreserved whole bovine and human ovaries using DMSO as a cryoprotectant.Journal of assisted reproduction and genetics · 2017Article
- Ovarian tissue transport to expand access to fertility preservation: from animals to clinical practice.Reproduction (Cambridge, England) · 2016Review
- Clinically applied procedures for human ovarian tissue cryopreservation result in different levels of efficacy and efficiency.Journal of assisted reproduction and genetics · 2016Article
- Fertility Preservation Options for Men and Women With Cancer.Reviews in urology · 2015Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the effect of cryopreservation and thawing of ovarian tissue from oncological patients opting for fertility preservation on ovarian tissue viability.
methodsIn this prospective cohort study, the ovarian tissue viability before and after cryopreservation and thawing was measured for 25 newly diagnosed oncological patients who had their ovarian tissue cryopreserved. Outcome measures were follicle integrity (histology), follicle viability (Calcein viability assay), steroid hormone production (estradiol and progesterone production in vitro) and overall tissue viability (glucose uptake in vitro). This study was conducted at a Cryobank for storage of ovarian tissue in a university hospital.
resultsCryopreserved/thawed ovarian tissue showed a decreased glucose uptake when compared to tissue that had not been cryopreserved. In addition, a diminished E2 and P4 production was observed after cryopreservation and thawing, despite the fact that numbers of viable follicles as determined by the Calcein viability assay were comparable. Histological examination revealed a higher percentage of degenerated follicles after cryopreservation and thawing.
conclusionsOvarian tissue cryopreservation and thawing impairs the viability of ovarian tissue in oncological patients opting for fertility preservation.
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