Evidence map›Paper›PMID 24928036›Full record

ArticleVirology2014

Cell entry of lymphocytic choriomeningitis virus is restricted in myotubes.

Masaharu Iwasaki, Shuzo Urata, Yoshitake Cho, Nhi Ngo, Juan C de la Torre

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
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4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Masaharu IwasakiDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA.
Shuzo UrataDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA.
Yoshitake ChoDepartment of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA.
Nhi NgoDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA.
Juan C de la TorreDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA. Electronic address: juanct@scripps.edu.
Scripps Research Institute · US

Funding

REVERSE GENETICS OF ARENAVIRUSESR01AI047140 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI DE LA TORRE, JUAN C. · 2001 to 2011
$3.0M
Targeting the processing of the arenavirus glycoprotein for anti-viral therapy.R01AI079665 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI DE LA TORRE, JUAN C. · 2009 to 2012
$1.9M
Anti-interferon Activity of the Arenavirus NucleoproteinR01AI077719 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI DE LA TORRE, JUAN C., MARTINEZ-SOBRIDO, LUIS · 2009 to 2012
$1.6M
NIAID NIH HHS R01 AI047140NIAID NIH HHS R01AI047140NIAID NIH HHS R01 AI077719NIAID NIH HHS R01AI077719NIAID NIH HHS R01 AI079665NIAID NIH HHS R01AI079665
6 · The paper itself

Abstract

In mice persistently infected since birth with the prototypic arenavirus lymphocytic choriomeningitis viurs, viral antigen and RNA are readily detected in most organs and cell types but remarkably absent in skeletal muscle. Here we report that mouse C2C12 myoblasts that are readily infected by LCMV, become highly refractory to LCMV infection upon their differentiation into myotubes. Myotube's resistance to LCMV was not due to an intracellular restriction of virus replication but rather an impaired cell entry mediated by the LCMV surface glycoprotein. Our findings provide an explanation for the observation that in LCMV carrier mice myotubes, which are constantly exposed to blood-containing virus, remain free of viral antigen and RNA despite myotubes express high levels of the LCMV receptor alpha dystroglycan and do not pose an intracellular blockade to LCMV multiplication.

Indexed as

Virus InternalizationAnimalsCaveolin 3Cell LineGene Expression RegulationLymphocytic choriomeningitis virusMiceMicroRNAsMuscle Fibers, SkeletalVirus ReplicationCaveolin 3MicroRNAsArenavirusCell entryLCMVMyoblastMyotubeSkeletal muscle

Identifiers

PMID24928036
PMCPMC4108482
OpenAlexW2091055131

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.