ArticleBMC research notes2014
Doppler ultrasound findings correlate with tissue vascularity and inflammation in surgical pathology specimens from patients with small intestinal Crohn's disease.
Article in BMC research notes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 60 citations in OpenAlex.
- Diagnostic accuracy of the international bowel ultrasound segmental activity score for assessing disease activity in Crohn's disease.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- Bowel Wall Vascularization in Crohn's Disease: Exploratory Comparison of Vendor-Derived Vascular Index, ImageJ-Based Quantification, and Blinded Video-Based Doppler Scoring.Diagnostics (Basel, Switzerland) · 2026Article
- Intestinal Ultrasound-Guided Precision Medicine in Inflammatory Bowel Diseases: A Narrative Review.Journal of personalized medicine · 2026Review
- Development and validation of a novel intestinal ultrasound score for predicting endoscopic activity of ileocecal ulcers in intestinal Behçet's disease.Journal of gastroenterology · 2026Article
- Submucosal hyper-echogenicity on intestinal ultrasound is associated with fat deposition and predicts treatment non-response in patients with ulcerative colitis.Journal of Crohn's & colitis · 2025Article
- Quantitative assessment of ultrasound microvessel imaging in Crohn's disease: correlation with pathological inflammation.European radiology · 2025Article
- Transabdominal intestinal ultrasound and its parameters used in the assessment of pediatric inflammatory bowel disease.World journal of clinical pediatrics · 2024Article
- A Comprehensive Multidisciplinary Approach to Diagnosing Chronic Inflammatory Bowel Diseases: Integration of Clinical, Endoscopic, and Imaging Modalities.Diagnostics (Basel, Switzerland) · 2024Review
- Intestinal ultrasound for intestinal Behçet disease reflects endoscopic activity and histopathological findings.Intestinal research · 2024Article
- Assessment of Ileal Crohn's Disease Activity by Gastrointestinal Ultrasound and MR Enterography: A Pilot Study.Life (Basel, Switzerland) · 2023Article
- How to Evaluate Fibrosis in IBD?Diagnostics (Basel, Switzerland) · 2023Review
- Treat to transmural healing: how to incorporate intestinal ultrasound into the treatment of inflammatory bowel disease.The British journal of radiology · 2022Review
- Ultrasound Elastography in the Assessment of the Intestinal Changes in Inflammatory Bowel Disease-Systematic Review.Journal of clinical medicine · 2021Review
- Bowel Ultrasound in Inflammatory Bowel Disease: How Far in the Grayscale?Life (Basel, Switzerland) · 2021Review
- Ultrasonographic Evaluation of Intestinal Fibrosis and Inflammation in Crohn's Disease. The State of the Art.Frontiers in pharmacology · 2021Review
- Ultrasound findings of Crohn's disease: correlation with MR enterography.Abdominal radiology (New York) · 2021Review
- Role of contrast-enhanced ultrasound in evaluation of the bowel.Abdominal radiology (New York) · 2018Review
- Light and sound - emerging imaging techniques for inflammatory bowel disease.World journal of gastroenterology · 2016Review
- Update on Magnetic Resonance Imaging and Ultrasound Evaluation of Crohn's Disease.Gastroenterology & hepatology · 2016Article
- Impact of Intestinal Ultrasound on Classification and Management of Crohn's Disease Patients with Inconclusive Colonoscopy.Canadian journal of gastroenterology & hepatology · 2016Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCrohn's disease (CD) is routinely evaluated using clinical symptoms, laboratory variables, and the CD activity index (CDAI). However, clinical parameters are often nonspecific and do not precisely reflect the actual activity of CD small-intestinal lesions. The purposes of this prospective study were to compare color Doppler ultrasound (US) findings with histological findings from surgically resected specimens and confirm the hypothesis that color Doppler US can distinguish tissue inflammation and fibrosis.
methodsAmong 1764 consecutive patients who underwent color Doppler US examinations, 10 patients with CD (12 small-intestinal CD lesions) who underwent US examinations before elective small-intestine resection were evaluated in the present study. Areas of thickened intestinal walls were evaluated in terms of blood flow using color Doppler US imaging. The blood flow was semiquantitatively classified as "hyper-flow" and "hypo-flow" according to the Limberg score. Resected lesions were macroscopically and histopathologically processed. Inflammatory cell infiltration, fibrosis and vascularity were evaluated by myeloperoxidase (granulocytes), CD163 (macrophages), CD79a (B cells), CD3 (T cells), Masson's trichrome (fibrosis), and factor VIII staining (vascular walls). All histopathological images were entered into virtual slide equipment and quantified using a quantitative microscopy integrated system (TissueMorph™).
resultsThere were no significant differences in disease features or laboratory findings between "hypo-flow" lesions (n = 4) and "hyper-flow" lesions (n = 8). Histopathologically, "hyper-flow" lesions showed significantly greater bowel wall vascularity (factor VIII) (p = 0.047) and inflammatory cell infiltration, including CD163 macrophages (p = 0.008), CD3 T cells, and CD79a B cells (p = 0.043), than did "hypo-flow" lesions. There was no apparent association between the blood flow and CDAI.
conclusionsIn this study, active CD lesions were macroscopically visible in surgical specimens of patients with increased blood flow on preoperative color Doppler US imaging. Additionally, these CD lesions exhibited significantly greater vascularity and numbers of inflammatory leukocytes microscopically. Color Doppler US may predict tissue inflammation and fibrosis in small-intenstinal CD lesions.
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