Evidence map›Paper›PMID 24927736›Full record

ArticleHuman molecular genetics2014

Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade.

Kristen S Purrington, Seth Slettedahl, Manjeet K Bolla, Kyriaki Michailidou, Kamila Czene, Heli Nevanlinna, Stig E Bojesen, Irene L Andrulis, Angela Cox, Per Hall and 157 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human molecular genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Association ofmedRxiv : the preprint server for health sciences · 2023
    Article
  2. Article
  3. Validation of the BOADICEA model and a 313-variant polygenic risk score for breast cancer risk prediction in a Dutch prospective cohort.Genetics in medicine : official journal of the American College of Medical Genetics · 2020
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Discriminatory power of common genetic variants in personalized breast cancer diagnosis.Proceedings of SPIE--the International Society for Optical Engineering · 2016
    Article
  9. Article
  10. Article
  11. Risk determination and prevention of breast cancer.Breast cancer research : BCR · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

167 authors at 20 institutions in 25 countries.

Kristen S PurringtonDepartment of Health Sciences Research, Department of Oncology, Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, USA.
Seth SlettedahlDepartment of Health Sciences Research.
Manjeet K BollaCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care.
Kyriaki MichailidouCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care.
Kamila CzeneDepartment of Medical Epidemiology and Biostatistics.
Heli NevanlinnaDepartment of Obstetrics and Gynecology.
Stig E BojesenCopenhagen General Population Study, Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.
Irene L AndrulisOntario Cancer Genetics Network, Department of Molecular Genetics.
Angela CoxCRUK/YCR Sheffield Cancer Research Centre, Department of Oncology.
Per HallDepartment of Medical Epidemiology and Biostatistics.
Jane CarpenterAustralian Breast Cancer Tissue Bank.
Drakoulis YannoukakosMolecular Diagnostics Laboratory INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA.
Peter A FaschingUniversity Breast Center Franconia, Department of Gynecology and Obstetrics, David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, USA.
Arto MannermaaSchool of Medicine, Institute of Clinical Medicine, Oncology, Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland, Imaging Center, Department of Clinical Pathology.
Robert WinqvistLaboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu University Hospital/NordLab Oulu, Oulu, Finland.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Consortium (DKTK), Heidelberg, Germany.
Annika LindblomDepartment of Molecular Medicine and Surgery.
Georgia Chenevix-TrenchDepartment of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Javier BenitezHuman Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain, Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain.
Anthony SwerdlowDivision of Genetics and Epidemiology, Division of Breast Cancer Research, Institute of Cancer Research, Sutton, UK.
Vessela KristensenDepartment of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway, Faculty of Medicine (Faculty Division Ahus), University of Oslo (UiO), Oslo, Norway.
Pascal GuénelInserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France, University Paris-Sud, UMRS 1018, Villejuif, France.
Alfons MeindlDivision of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany.
Hatef DarabiDepartment of Medical Epidemiology and Biostatistics.
Mikael ErikssonDepartment of Medical Epidemiology and Biostatistics.
Rainer FagerholmDepartment of Obstetrics and Gynecology, Oncology and Clinical Genetics.
Kristiina AittomäkiDepartment of Clinical Genetics.
Carl BlomqvistDepartment of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Børge G NordestgaardDepartment of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.
Sune F NielsenCopenhagen General Population Study.
Henrik FlygerDepartment of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Xianshu WangDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, USA.
Curtis OlswoldDepartment of Health Sciences Research.
Janet E OlsonDepartment of Health Sciences Research.
Anna Marie MulliganDepartment of Laboratory Medicine and Pathobiology, Laboratory Medicine Program, University Health Network, Toronto, Canada.
Julia A KnightProsserman Centre for Health Research, Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.
Sandrine TchatchouLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada.
Malcolm W R ReedCRUK/YCR Sheffield Cancer Research Centre, Department of Oncology.
Simon S CrossAcademic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK.
Jianjun LiuHuman Genetics Division, Genome Institute of Singapore, Singapore, Singapore.
Jingmei LiHuman Genetics Division, Genome Institute of Singapore, Singapore, Singapore.
Keith HumphreysDepartment of Medical Epidemiology and Biostatistics.
Christine ClarkeWestmead Institute for Cancer Research, Sydney Medical School Westmead, University of Sydney at the Westmead Millennium Institute, Westmead, Australia.
Rodney ScottDivision of Genetics, Hunter Area Pathology Service and University of Newcastle, Newcastle, Australia.
ABCTB Investigators
Florentia FostiraMolecular Diagnostics Laboratory INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece.
George FountzilasDepartment of Medical Oncology, "Papageorgiou" Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece.
Irene KonstantopoulouMolecular Diagnostics Laboratory INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece.
Brian E HendersonDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA.
Fredrick SchumacherDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA.
Loic Le MarchandEpidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, USA.
Arif B EkiciInstitute of Human Genetics.
Arndt HartmannInstitute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
Matthias W BeckmannUniversity Breast Center Franconia, Department of Gynecology and Obstetrics.
Jaana M HartikainenSchool of Medicine, Institute of Clinical Medicine, Oncology, Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland, Imaging Center, Department of Clinical Pathology.
Veli-Matti KosmaSchool of Medicine, Institute of Clinical Medicine, Oncology, Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland, Imaging Center, Department of Clinical Pathology.
Vesa KatajaSchool of Medicine, Institute of Clinical Medicine, Oncology, Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland, Cancer Center, Kuopio University Hospital, Kuopio, Finland.
Arja Jukkola-VuorinenDepartment of Oncology.
Katri PylkäsLaboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu University Hospital/NordLab Oulu, Oulu, Finland.
Saila KauppilaDepartment of Pathology, Oulu University Hospital, University of Oulu, Oulu, Finland.
Aida Karina DieffenbachDivision of Clinical Epidemiology and Aging Research, German Cancer Consortium (DKTK), Heidelberg, Germany.
Christa StegmaierSaarland Cancer Registry, Saarbrücken, Germany.
Volker ArndtDivision of Clinical Epidemiology and Aging Research.
Sara MargolinDepartment of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Australian Ovarian Cancer Study Group
kConFab Investigators
Rosemary BalleineWestmead Millenium Institute for Medical Research, Sydney, Australia.
Jose Ignacio Arias PerezServicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain.
M Pilar ZamoraServicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain.
Primitiva MenéndezServicio de Anatomía Patológica.
Alan AshworthBreakthrough Breast Cancer Research Centre and Division of Breast Cancer Research.
Michael JonesDivision of Genetics and Epidemiology.
Nick OrrBreakthrough Breast Cancer Research Centre and Division of Breast Cancer Research.
Patrick ArveuxCenter Georges-Francois Leclerc, Registry of Gynecologic Tumors, Dijon, France.
Pierre KerbratCentre Eugène Marquis, Department of Medical Oncology, Rennes, France.
Thérèse TruongInserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France, University Paris-Sud, UMRS 1018, Villejuif, France.
Peter BugertGerman Red Cross Blood Service of Baden-Württemberg-Hessen, Mannheim, Germany, Medical Faculty Mannheim, Institute of Transfusion Medicine and Immunology, Heidelberg University, Heidelberg, Germany.
Amanda E TolandDepartment of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, USA.
Christine B AmbrosoneRoswell Park Cancer Institute, Buffalo, USA.
France LabrècheDepartment of Environmental & Occupational Health and of Social & Preventive Medicine, School of Public Health, Université de Montréal, Montreal, Canada.
Mark S GoldbergDepartment of Medicine, McGill University, Montreal, Canada, Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, Montreal, Canada.
Martine DumontCancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City, Canada.
Argyrios ZiogasDepartment of Epidemiology, University of California Irvine, Irvine, USA.
Eunjung LeeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA.
Gillian S DiteCentre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health.
Carmel ApicellaCentre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health.
Melissa C SoutheyDepartment of Pathology.
Jirong LongDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, USA.
Martha ShrubsoleDepartment of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, USA.
Sandra Deming-HalversonDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, USA.
Filomena FicarazziCogentech Cancer Genetic Test Laboratory, Milan, Italy, IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy.
Monica BarileDivision of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy.
Paolo PeterlongoIFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy.
Katarzyna DurdaDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Katarzyna Jaworska-BieniekDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Robert A E M TollenaarDepartment of Surgical Oncology.
Caroline SeynaeveFamily Cancer Clinic, Department of Medical Oncology, Erasmus MC-Daniel den Hoed Cancer Centrer, Rotterdam, The Netherlands.
GENICA Network
Thomas BrüningInstitute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum, Germany.
Yon-Dschun KoDepartment of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany.
Carolien H M Van DeurzenDepartment of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands.
John W M MartensDepartment of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Mieke KriegeDepartment of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Jonine D FigueroaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, USA.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, USA.
Jolanta LissowskaDepartment of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Warsaw, Poland.
Ian TomlinsonWellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
Michael J KerinClinical Science Institute, University Hospital Galway, Galway, Ireland.
Nicola MillerClinical Science Institute, University Hospital Galway, Galway, Ireland.
Andreas SchneeweissDepartment of Obstetrics and Gynecology, National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany.
William J TapperFaculty of Medicine, University of Southampton, Southampton, UK.
Susan M GertyFaculty of Medicine, University of Southampton, Southampton, UK.
Lorraine DurcanFaculty of Medicine, University of Southampton, Southampton, UK.
Catriona McleanAnatomical Pathology, The Alfred Hospital, Melbourne, Australia.
Roger L MilneCentre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia, Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia.
Laura BagliettoCentre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia, Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia.
Isabel dos Santos SilvaNon-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.
Olivia FletcherBreakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.
Nichola JohnsonBreakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.
Laura J Van'T VeerNetherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Sten CornelissenNetherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Asta FörstiDivision of Molecular Genetic Epidemiology, Center for Primary Health Care Research, University of Lund, Malmö, Sweden.
Diana TorresMolecular Genetics of Breast Cancer, Institute of Human Genetics, Pontificia University Javeriana, Bogota, Colombia.
Thomas RüdigerInstitute of Pathology, Städtisches Klinikum Karlsruhe, Karlsruhe, Germany.
Anja RudolphDivision of Cancer Epidemiology.
Dieter Flesch-JanysDepartment of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany.
Stefan NickelsDivision of Cancer Epidemiology.
Caroline WeltensUniversital Hospital Gasthuisberg, Leuven, Belgium.
Giuseppe FlorisUniversital Hospital Gasthuisberg, Leuven, Belgium.
Matthieu MoisseLaboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium, Vesalius Research Center (VRC), VIB, Leuven, Belgium.
Joe DennisCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care.
Qin WangCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care.
Alison M DunningCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Mitul ShahCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Judith BrownCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care.
Jacques SimardCancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City, Canada.
Hoda Anton-CulverDepartment of Epidemiology, University of California Irvine, Irvine, USA.
Susan L NeuhausenBeckman Research Institute of City of Hope, Duarte, USA.
John L HopperCentre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health.
Natalia BogdanovaDepartment of Radiation Oncology.
Thilo DörkDepartment of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, USA.
Paolo RadiceUnit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy and.
Anna JakubowskaDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Jan LubinskiDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Peter DevilleeDepartment of Human Genetics & Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
Hiltrud BrauchDr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany, University of Tübingen, Tübingen, Germany.
Maartje HooningDepartment of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Montserrat García-ClosasBreakthrough Breast Cancer Research Centre and Division of Breast Cancer Research.
Elinor SawyerDivision of Cancer Studies, Kings College London, Guy's Hospital, London, UK.
Barbara BurwinkelDepartment of Obstetrics and Gynecology, Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Frederick MarmeeDepartment of Obstetrics and Gynecology, National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany.
Diana M EcclesFaculty of Medicine, University of Southampton, Southampton, UK.
Graham G GilesCentre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia, Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia.
Julian PetoNon-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.
Marjanka SchmidtNetherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Annegien BroeksNetherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Ute HamannMolecular Genetics of Breast Cancer.
Jenny Chang-ClaudeDivision of Cancer Epidemiology.
Diether LambrechtsLaboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium, Vesalius Research Center (VRC), VIB, Leuven, Belgium.
Paul D P PharoahCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Douglas EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
V Shane PankratzDepartment of Health Sciences Research.
Susan SlagerDepartment of Health Sciences Research.
Celine M VachonDepartment of Health Sciences Research.
Fergus J CouchDepartment of Health Sciences Research, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, USA, couch.fergus@mayo.edu.
Department of Medical Sciences · BYErasmus MC Cancer Institute · NLPomeranian Medical University · PLThe Netherlands Cancer Institute · NLUniversity of Cambridge · GBUniversity of Eastern Finland · FIUniversity of Southampton · GBUniversity of Southern California · USBreast Cancer Research Foundation · USGerman Cancer Research Center · DEHeidelberg University · DEInstitute of Cancer Research · GBNational Centre of Scientific Research "Demokritos" · GROulu University Hospital · FIThe University of Melbourne · AUVanderbilt University · USCentre hospitalier universitaire de Québec · CAGenome Institute of Singapore · SGIFOM · ITLondon School of Hygiene & Tropical Medicine · GB

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Felicity Enders · 1985 to 2026
$151.3M
Hormone-Related CancersZIACP010126 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI GIERACH, GRETCHEN · 2009 to 2025
$103.5M
The Role of CHFR in Tumorigenesis and Paclitaxel-Sensitivity in Breast CancerP50CA116201 · NCI · MAYO CLINIC ROCHESTER · PI PETER C LUCAS · 2005 to 2026
$49.9M
Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
CALIFORNIA TEACHERS STUDYR01CA077398 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BERNSTEIN, LESLIE · 1998 to 2014
$29.7M
GENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTSR01CA063464 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2001 to 2005
$23.2M
Multiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2M
Northern California Cooperative Family Registry for Breast CancerU01CA069417 · NCI · NORTHERN CALIFORNIA CANCER CENTER · PI JOHN, ESTHER M. · 1995 to 2010
$22.4M
Breast Cancer Family Registry CohortUM1CA164920 · NCI · CANCER PREVENTION INSTIT OF CALIFORNIA · PI ANDRULIS, IRENE, BUYS, SAUNDRA S · 2012 to 2017
$12.7M
Characterizing Genetic Susceptibility to Breast and Prostate Cancer; the BPC3U01CA098758 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2003 to 2010
$11.0M
Epidemiologic StudiesU19CA148065 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI AHSAN, HABIBUL, BRUGGE, JOAN SIEFERT · 2010 to 2014
$10.6M
Cancer Research UK 10124Cancer Research UK 16561Cancer Research UK 16563Cancer Research UK 16565Cancer Research UK C12292/A11174Cancer Research UK C1281/A12014Cancer Research UK C1287/A10118Cancer Research UK C1287/A 10710Cancer Research UK C1287/A12014Cancer Research UK C490/A10124Cancer Research UK C5047/A10692Cancer Research UK C5047/A15007Cancer Research UK C5047/A8384CIHR CRN-87521NCATS NIH HHS UL1 TR000135NCI NIH HHS 1U19 CA148065NCI NIH HHS 1U19 CA148112NCI NIH HHS 1U19 CA148537NCI NIH HHS CA098758NCI NIH HHS CA116201NCI NIH HHS CA128978NCI NIH HHS CA132839NCI NIH HHS CA54281NCI NIH HHS CA63464NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA068485NCI NIH HHS P30 CA68485NCI NIH HHS P50 CA116201NCI NIH HHS R01 CA054281NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA077398NCI NIH HHS R01 CA100374NCI NIH HHS R01CA100374NCI NIH HHS R01 CA128978NCI NIH HHS R01 CA132839NCI NIH HHS R01 CA77398NCI NIH HHS R37 CA054281NCI NIH HHS RFA-CA-06-503NCI NIH HHS U01 CA063464NCI NIH HHS U01 CA069417NCI NIH HHS U01 CA069467NCI NIH HHS U01 CA069638NCI NIH HHS U01 CA098758NCI NIH HHS U01 CA69417NCI NIH HHS U01 CA69467NCI NIH HHS U01 CA69638NCI NIH HHS U19 CA148065NCI NIH HHS U19 CA148112NCI NIH HHS U19 CA148537NCI NIH HHS UM1 CA164920Wellcome Trust 090532
6 · The paper itself

Abstract

Mitotic index is an important component of histologic grade and has an etiologic role in breast tumorigenesis. Several small candidate gene studies have reported associations between variation in mitotic genes and breast cancer risk. We measured associations between 2156 single nucleotide polymorphisms (SNPs) from 194 mitotic genes and breast cancer risk, overall and by histologic grade, in the Breast Cancer Association Consortium (BCAC) iCOGS study (n = 39 067 cases; n = 42 106 controls). SNPs in TACC2 [rs17550038: odds ratio (OR) = 1.24, 95% confidence interval (CI) 1.16-1.33, P = 4.2 × 10(-10)) and EIF3H (rs799890: OR = 1.07, 95% CI 1.04-1.11, P = 8.7 × 10(-6)) were significantly associated with risk of low-grade breast cancer. The TACC2 signal was retained (rs17550038: OR = 1.15, 95% CI 1.07-1.23, P = 7.9 × 10(-5)) after adjustment for breast cancer risk SNPs in the nearby FGFR2 gene, suggesting that TACC2 is a novel, independent genome-wide significant genetic risk locus for low-grade breast cancer. While no SNPs were individually associated with high-grade disease, a pathway-level gene set analysis showed that variation across the 194 mitotic genes was associated with high-grade breast cancer risk (P = 2.1 × 10(-3)). These observations will provide insight into the contribution of mitotic defects to histological grade and the etiology of breast cancer.

Indexed as

Genetic VariationBreast NeoplasmsCarrier ProteinsCase-Control StudiesFemaleHaplotypesHumansNeoplasm StagingPolymorphism, Single NucleotideReceptor, Fibroblast Growth Factor, Type 2Risk FactorsTumor Suppressor ProteinsCarrier ProteinsReceptor, Fibroblast Growth Factor, Type 2TACC2 protein, humanTumor Suppressor Proteins

Identifiers

PMID24927736
PMCPMC4204763
OpenAlexW2147060099

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