Evidence map›Paper›PMID 24927679›Full record

ArticleBiomaterials2014

Tough and flexible CNT-polymeric hybrid scaffolds for engineering cardiac constructs.

Mahshid Kharaziha, Su Ryon Shin, Mehdi Nikkhah, Seda Nur Topkaya, Nafiseh Masoumi, Nasim Annabi, Mehmet R Dokmeci, Ali Khademhosseini

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed.

  1. Article
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  8. Article
  9. Novel Electroactive Therapeutic Platforms for Cardiac Arrhythmia Management.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
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  11. Review
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  13. Article
  14. Article
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mahshid KharazihaBiomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Woman's Hospital, Harvard Medical School, Boston, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan, 8415683111, Iran.
Su Ryon ShinBiomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Woman's Hospital, Harvard Medical School, Boston, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
Mehdi NikkhahBiomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Woman's Hospital, Harvard Medical School, Boston, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Seda Nur TopkayaBiomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Woman's Hospital, Harvard Medical School, Boston, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Ege University, Faculty of Pharmacy, Department of Analytical Chemistry, Izmir, TR-35100 Turkey.
Nafiseh MasoumiBiomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Woman's Hospital, Harvard Medical School, Boston, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Nasim AnnabiBiomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Woman's Hospital, Harvard Medical School, Boston, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
Mehmet R DokmeciBiomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Woman's Hospital, Harvard Medical School, Boston, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
Ali KhademhosseiniBiomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Woman's Hospital, Harvard Medical School, Boston, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul 130-701, Republic of Korea; Department of Physics, King Abdulaziz University, Jeddah 21569, Saudi Arabia. Electronic address: alik@rics.bwh.harvard.edu.

Funding

Microengineered Osteons for Bone Tissue EngineeringR01AR057837 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI YANG, YUNZHI · 2010 to 2018
$5.1M
3D combinatorial microenvironments for effective cell based therapyR01HL099073 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI KHADEMHOSSEINI, ALI, LIAO, RONGLIH · 2010 to 2013
$2.6M
Microfabricated Vascularized 3D Tissue Engineered ConstructsR01HL092836 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI KHADEMHOSSEINI, ALI · 2008 to 2012
$2.4M
Microengineered environments for epithelial-mesenchymal interactions (SysCODE 7RL1DE019024 · NIDCR · BRIGHAM AND WOMEN'S HOSPITAL · PI KHADEMHOSSEINI, ALI · 2007 to 2011
$1.9M
Engineering Vascularized Bone Tissues By Microfabrication And ScaffoldingR01DE021468 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI YANG, YUNZHI · 2011 to 2014
$1.8M
A Microfabrication Platform for Direct Printing Vascularized Functional Tissue CoR01EB012597 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, SHAOCHEN · 2010 to 2013
$1.4M
MICROFLUIDIC SYSTEM FOR SCREENING STEM CELL MICROENVIRONMENTSR01EB008392 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI KHADEMHOSSEINI, ALI · 2009 to 2010
$820k
NHLBI NIH HHS HL092836NHLBI NIH HHS HL099073NHLBI NIH HHS R01 HL092836NHLBI NIH HHS R01 HL099073NIAMS NIH HHS AR057837NIAMS NIH HHS R01 AR057837NIBIB NIH HHS EB008392NIBIB NIH HHS EB012597NIBIB NIH HHS R01 EB008392NIBIB NIH HHS R01 EB012597NIDCR NIH HHS DE019024NIDCR NIH HHS DE021468NIDCR NIH HHS R01 DE021468NIDCR NIH HHS RL1 DE019024
6 · The paper itself

Abstract

In the past few years, a considerable amount of effort has been devoted toward the development of biomimetic scaffolds for cardiac tissue engineering. However, most of the previous scaffolds have been electrically insulating or lacked the structural and mechanical robustness to engineer cardiac tissue constructs with suitable electrophysiological functions. Here, we developed tough and flexible hybrid scaffolds with enhanced electrical properties composed of carbon nanotubes (CNTs) embedded aligned poly(glycerol sebacate):gelatin (PG) electrospun nanofibers. Incorporation of varying concentrations of CNTs from 0 to 1.5% within the PG nanofibrous scaffolds (CNT-PG scaffolds) notably enhanced fiber alignment and improved the electrical conductivity and toughness of the scaffolds while maintaining the viability, retention, alignment, and contractile activities of cardiomyocytes (CMs) seeded on the scaffolds. The resulting CNT-PG scaffolds resulted in stronger spontaneous and synchronous beating behavior (3.5-fold lower excitation threshold and 2.8-fold higher maximum capture rate) compared to those cultured on PG scaffold. Overall, our findings demonstrated that aligned CNT-PG scaffold exhibited superior mechanical properties with enhanced CM beating properties. It is envisioned that the proposed hybrid scaffolds can be useful for generating cardiac tissue constructs with improved organization and maturation.

Indexed as

AnimalsBiocompatible MaterialsCells, CulturedDecanoatesElectric ConductivityGelatinGlycerolMyocardiumMyocytes, CardiacNanofibersNanotubes, CarbonPolymersRats, Sprague-DawleyTissue EngineeringTissue ScaffoldsBiocompatible MaterialsDecanoatesGelatinGlycerolNanotubes, Carbonpoly(glycerol-sebacate)PolymersCarbon Nanotubes (CNTs)Cardiac tissue engineeringCardiomyocytePoly(glycerol sebacate):gelatinScaffold

Identifiers

PMID24927679
PMCPMC4114042

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.