Trial reportProceedings of the National Academy of Sciences of the United States of America2014
Immersive audiomotor game play enhances neural and perceptual salience of weak signals in noise.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed.
- Audiomotor Perceptual Training Enhances Speech Intelligibility in Background Noise.Current biology : CB · 2017Trial
- The human brain modulates sniffs according to fine-grained perceptual features of odours.Nature human behaviour · 2026Article
- Effects of Gamification on Performance and Subjective Listening Effort on a Spatial Release From Masking Task.Journal of speech, language, and hearing research : JSLHR · 2025Article
- An auditory cortical-striatal circuit supports sound-triggered timing to predict future events.PLoS biology · 2025Article
- Auditory Training Alters the Cortical Representation of Complex Sounds.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neural Correlates of Perceptual Plasticity in the Auditory Midbrain and Thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A Brain-Computer Interface for Improving Auditory Attention in Multi-Talker Environments.IEEE access : practical innovations, open solutions · 2025Article
- Sound elicits stereotyped facial movements that provide a sensitive index of hearing abilities in mice.Current biology : CB · 2024Article
- Neural correlates of flexible sound perception in the auditory midbrain and thalamus.bioRxiv : the preprint server for biology · 2024Article
- A Cortico-Striatal Circuit for Sound-Triggered Prediction of Reward Timing.bioRxiv : the preprint server for biology · 2023Article
- Auditory cortex ensembles jointly encode sound and locomotion speed to support sound perception during movement.PLoS biology · 2023Article
- Neurotoxicity and Outcomes from Developmental Lead Exposure: Persistent or Permanent?Environmental health perspectives · 2023Article
- Neural Mechanisms Related to the Enhanced Auditory Selective Attention Following Neurofeedback Training: Focusing on Cortical Oscillations.Applied sciences (Basel, Switzerland) · 2023Article
- Effects of Gamification on Assessment of Spatial Release From Masking.American journal of audiology · 2023Article
- Rabbits use both spectral and temporal cues to discriminate the fundamental frequency of harmonic complexes with missing fundamentals.Journal of neurophysiology · 2022Article
- Auditory Perceptual Exercises in Adults Adapting to the Use of Hearing Aids.Frontiers in psychology · 2022Article
- An Active Sensing Paradigm for Studying Human Auditory Perception.Frontiers in integrative neuroscience · 2022Article
- Training with an auditory perceptual learning game transfers to speech in competition.Journal of cognitive enhancement : towards the integration of theory and practice · 2022Article
- Cochlear neural degeneration disrupts hearing in background noise by increasing auditory cortex internal noise.Neuron · 2021Article
- Improving older adults' understanding of challenging speech: Auditory training, rapid adaptation and perceptual learning.Hearing research · 2021Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
All sensory systems face the fundamental challenge of encoding weak signals in noisy backgrounds. Although discrimination abilities can improve with practice, these benefits rarely generalize to untrained stimulus dimensions. Inspired by recent findings that action video game training can impart a broader spectrum of benefits than traditional perceptual learning paradigms, we trained adult humans and mice in an immersive audio game that challenged them to forage for hidden auditory targets in a 2D soundscape. Both species learned to modulate their angular search vectors and target approach velocities based on real-time changes in the level of a weak tone embedded in broadband noise. In humans, mastery of this tone in noise task generalized to an improved ability to comprehend spoken sentences in speech babble noise. Neural plasticity in the auditory cortex of trained mice supported improved decoding of low-intensity sounds at the training frequency and an enhanced resistance to interference from background masking noise. These findings highlight the potential to improve the neural and perceptual salience of degraded sensory stimuli through immersive computerized games.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.