Trial reportProceedings of the National Academy of Sciences of the United States of America2014
Resting GABA and glutamate concentrations do not predict visual gamma frequency or amplitude.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 105 citations in OpenAlex.
- No effects of transcranial direct current stimulation on visual evoked potential and peak gamma frequency.Cognitive processing · 2022Trial
- Tagged MEG measures binocular rivalry in a cortical network that predicts alternation rate.PloS one · 2019Trial
- Concurrent Multimodal Imaging Demonstrates That EEG-Based Excitation/Inhibition Balance Reflects Glutamate and GABA Balance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Neurochemical-hemodynamic-electrophysiological coupling in the neonatal brain: a multimodal MRS-fMRI-EEG investigation.Frontiers in neuroscience · 2026Article
- Article
- 40 Hz Steady-State Response in Human Auditory Cortex Is Shaped by Gabaergic Neuronal Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- GABAergic inhibition shapes behavior and neural dynamics in human visual working memory.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Excitation-Inhibition Imbalance in Migraine: From Neurotransmitters to Brain Oscillations.International journal of molecular sciences · 2023Review
- Individual/Peak Gamma Frequency: What Do We Know?Brain sciences · 2023Review
- The Possibility of Eidetic Memory in a Patient Report of Epileptogenic Zone in Right Temporo-Parietal-Occipital Cortex.Life (Basel, Switzerland) · 2023Article
- From mechanisms to markers: novel noninvasive EEG proxy markers of the neural excitation and inhibition system in humans.Translational psychiatry · 2022Review
- Investigating the neurochemistry of the human visual system using magnetic resonance spectroscopy.Brain structure & function · 2022Review
- Article
- Six-dimensional dynamic tractography atlas of language connectivity in the developing brain.Brain : a journal of neurology · 2021Article
- Visual gamma oscillations predict sensory sensitivity in females as they do in males.Scientific reports · 2021Article
- Article
- The visual cortex produces gamma band echo in response to broadband visual flicker.PLoS computational biology · 2021Article
- Interictal Activity Is Associated With Slower Binocular Rivalry in Idiopathic Generalized Epilepsy.Frontiers in neurology · 2021Article
- High γ-Aminobutyric Acid Content Within the Medial Prefrontal Cortex Is a Functional Signature of Somatic Symptoms Disorder in Patients With Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2020Article
- Methodological considerations for a better somatosensory gating paradigm: The impact of the inter-stimulus interval.NeuroImage · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
Gamma band oscillations arise in neuronal networks of interconnected GABAergic interneurons and excitatory pyramidal cells. A previous study found a correlation between visual gamma peak frequency, as measured with magnetoencephalography, and resting GABA levels, as measured with magnetic resonance spectroscopy (MRS), in 12 healthy volunteers. If true, this would allow studies in clinical populations testing modulation of this relationship, but this finding has not been replicated. We addressed this important question by measuring gamma oscillations and GABA, as well as glutamate, in 50 healthy volunteers. Visual gamma activity was evoked using an established gratings paradigm, and we applied a beamformer spatial filtering technique to extract source-reconstructed gamma peak frequency and amplitude from the occipital lobe. We determined gamma peak frequency and amplitude from the location with maximal activation and from the location of the MRS voxel to assess the relationship of GABA with gamma. Gamma peak frequency was estimated from the highest value of the raw spectra and by a Gaussian fit to the spectra. MRS data were acquired from occipital cortex. We did not replicate the previously found correlation between gamma peak frequency and GABA concentration. Calculation of a Bayes factor provided strong evidence in favor of the null hypothesis. We also did not find a correlation between gamma activity and glutamate or between gamma and the ratio of GABA/glutamate. Our results suggest that cortical gamma oscillations do not have a consistent, demonstrable relationship to excitatory/inhibitory network activity as proxied by MRS measurements of GABA and glutamate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.