ArticleProceedings of the National Academy of Sciences of the United States of America2014
Evolutionary developmental transcriptomics reveals a gene network module regulating interspecific diversity in plant leaf shape.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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83 citing papers in PubMed, 184 citations in OpenAlex.
- The genomic basis of adaptive leaf variation in the Galápagos giant daisies.Nature communications · 2026Article
- The C2H2-type zinc finger protein SlHair5 acts as a regulatory node coordinating trichome development and leaf morphogenesis in tomato.Plant cell reports · 2026Article
- Organ-level gene-regulatory networks inferred from transcriptomic data reveal context-specific regulation and highlight novel regulators of ripening and ABA-mediated responses in tomato.Plant communications · 2025Article
- Titanium ions promote tomato growth and increase stress resistance.BMC plant biology · 2025Article
- Gene expression and pollen performance indicate altered postmating selection between Solanum species with different mating systems.G3 (Bethesda, Md.) · 2025Article
- Shaping leaves through TALE homeodomain transcription factors.Journal of experimental botany · 2024Review
- Dynamic patterns of gene expressional and regulatory variations in cotton heterosis.Frontiers in plant science · 2024Article
- Identification of a potential homeodomain-like gene governing leaf size and venation architecture in birch.Frontiers in plant science · 2024Article
- Ancient allopatry and ecological divergence act together to promote plant diversity in mountainous regions: evidence from comparative phylogeography of two genera in the Sino-Himalayan region.BMC plant biology · 2023Article
- Diversity and genetic architecture of agro-morphological traits in a core collection of European traditional tomato.Journal of experimental botany · 2023Article
- Deciphering the Molecular Mechanisms of Autonomic Nervous System Neuron Induction through Integrative Bioinformatics Analysis.International journal of molecular sciences · 2023Article
- Diversity of tomato leaf form provides novel insights into breeding.Breeding science · 2023Article
- Overexpression of theInternational journal of molecular sciences · 2023Article
- Model-based reconstruction of whole organ growth dynamics reveals invariant patterns in leaf morphogenesis.Quantitative plant biology · 2023Article
- Genome-wide characterization of the TALE homeodomain family and the KNOX-BLH interaction network in tomato.Plant molecular biology · 2022Article
- Molecular mechanisms underlying leaf development, morphological diversification, and beyond.The Plant cell · 2022Review
- Evolution of miRNA-Binding Sites and Regulatory Networks in Cichlids.Molecular biology and evolution · 2022Article
- Heinz-resistant tomato cultivars exhibit a lignin-based resistance to field dodder (Cuscuta campestris) parasitism.Plant physiology · 2022Article
- Review
- Brachypodium distachyon UNICULME4 and LAXATUM-A are redundantly required for development.Plant physiology · 2022Article
23 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite a long-standing interest in the genetic basis of morphological diversity, the molecular mechanisms that give rise to developmental variation are incompletely understood. Here, we use comparative transcriptomics coupled with the construction of gene coexpression networks to predict a gene regulatory network (GRN) for leaf development in tomato and two related wild species with strikingly different leaf morphologies. The core network in the leaf developmental GRN contains regulators of leaf morphology that function in global cell proliferation with peripheral gene network modules (GNMs). The BLADE-ON-PETIOLE (BOP) transcription factor in one GNM controls the core network by altering effective concentration of the KNOTTED-like HOMEOBOX gene product. Comparative network analysis and experimental perturbations of BOP levels suggest that variation in BOP expression could explain the diversity in leaf complexity among these species through dynamic rewiring of interactions in the GRN. The peripheral location of the BOP-containing GNM in the leaf developmental GRN and the phenotypic mimics of evolutionary diversity caused by alteration in BOP levels identify a key role for this GNM in canalizing the leaf morphospace by modifying the maturation schedule of leaves to create morphological diversity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.