ArticleProceedings of the National Academy of Sciences of the United States of America2014
GroEL from the endosymbiont Buchnera aphidicola betrays the aphid by triggering plant defense.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.
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102 citing papers in PubMed, 219 citations in OpenAlex.
- Honeydew microbial ecology: a neglected frontier in multitrophic networks.FEMS microbiology ecology · 2026Review
- Molecular and transcriptional regulation of plant defense responses to aphid infestation.Stress biology · 2026Review
- Cross-kingdom signaling manipulation by insect-associated microbial symbionts: Linking molecular mechanisms to pest management strategies.Pest management science · 2026Review
- Molecular interface of plant-insect warfare: functions and applications of salivary effectors in piercing-sucking pests.Pest management science · 2026Review
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- Plant-Aphid Interactions in Cereal Crops: Wheat Plant Defense and Aphid Saliva-Mediated Coevolutionary Arms Race.Insects · 2026Review
- Is the endophyte-based plant protection against aphids mediated by changes in the insect microbiome?Insect science · 2026Article
- Pea transcriptional and phytohormonal responses to adapted and non-adapted aphid biotypes at early stages of infestation.Scientific reports · 2026Article
- Symbiotic weaponry: the role of bacterial mediators in aphid-plant defense conflicts.Archives of microbiology · 2026Review
- Endosymbionts affect plant virus transmission by winged and wingless aphids.ISME communications · 2026Article
- Viral Systemic Movement Is Enhanced by Alteration of a Structural Phloem Protein by the Insect Vector.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Aphid effector Mp10 balances immune suppression and defence activation through EDS1-dependent modulation of plant DAMP responses.The New phytologist · 2025Article
- Transcriptomic analysis reveals candidate molecular pathways involved in pea (Pisum sativum L.) resistance to pea aphid (Acyrthosiphon pisum Harris) biotypes.BMC genomics · 2025Article
- Plant-aphid interactions: recent trends in plant resistance to aphids.Stress biology · 2025Review
- Identification and functional analysis of putative effector proteins fromFrontiers in plant science · 2025Article
- Bacteria Derived from Diamondback Moth,Insects · 2024Article
- Molecular Interactions Between Plants and Aphids: Recent Advances and Future Perspectives.Insects · 2024Review
- The molecular dynamics between reactive oxygen species (ROS), reactive nitrogen species (RNS) and phytohormones in plant's response to biotic stress.Plant cell reports · 2024Review
- The perception and evolution of flagellin, cold shock protein and elongation factor Tu from vector-borne bacterial plant pathogens.Molecular plant pathology · 2024Article
- Salivary Protein Cyclin-Dependent Kinase-like from Grain AphidInternational journal of molecular sciences · 2024Article
42 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aphids are sap-feeding plant pests and harbor the endosymbiont Buchnera aphidicola, which is essential for their fecundity and survival. During plant penetration and feeding, aphids secrete saliva that contains proteins predicted to alter plant defenses and metabolism. Plants recognize microbe-associated molecular patterns and induce pattern-triggered immunity (PTI). No aphid-associated molecular pattern has yet been identified. By mass spectrometry, we identified in saliva from potato aphids (Macrosiphum euphorbiae) 105 proteins, some of which originated from Buchnera, including the chaperonin GroEL. Because GroEL is a widely conserved bacterial protein with an essential function, we tested its role in PTI. Applying or infiltrating GroEL onto Arabidopsis (Arabidopsis thaliana) leaves induced oxidative burst and expression of PTI early marker genes. These GroEL-induced defense responses required the known coreceptor BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED RECEPTOR KINASE 1. In addition, in transgenic Arabidopsis plants, inducible expression of groEL activated PTI marker gene expression. Moreover, Arabidopsis plants expressing groEL displayed reduced fecundity of the green peach aphid (Myzus persicae), indicating enhanced resistance against aphids. Furthermore, delivery of GroEL into tomato (Solanum lycopersicum) or Arabidopsis through Pseudomonas fluorescens, engineered to express the type III secretion system, also reduced potato aphid and green peach aphid fecundity, respectively. Collectively our data indicate that GroEL is a molecular pattern that triggers PTI.
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