ArticleAmerican journal of respiratory and critical care medicine2014
Risk of current asthma among adult smokers with respiratory syncytial virus illnesses in early life.
Article in American journal of respiratory and critical care medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Assessing the strength of evidence for a causal effect of respiratory syncytial virus lower respiratory tract infections on subsequent wheezing illness: a systematic review and meta-analysis.The Lancet. Respiratory medicine · 2020Pooled it
- Non-atopic rhinitis at age 6 is associated with subsequent development of asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Trial
- The life course impact of adverse childhood experiences on chronic pulmonary disease: the roles of inflammatory response and social buffering.Innovation in aging · 2026Article
- Predictors of prolonged length of stay in adult patients with respiratory syncytial virus infections - a multi-center historical cohort study.Frontiers in microbiology · 2024Article
- How early life respiratory viral infections impact airway epithelial development and may lead to asthma.Frontiers in pediatrics · 2024Review
- Creatine Kinase Is Decreased in Childhood Asthma.American journal of respiratory and critical care medicine · 2023Article
- Winds of change a tale of: asthma and microbiome.Frontiers in microbiology · 2023Review
- Lower respiratory illnesses in childhood are associated with the presence of air trapping in early adulthood.Respiratory medicine · 2023Article
- A Durable Relationship: Respiratory Syncytial Virus Bronchiolitis and Asthma past Their Golden Anniversary.Vaccines · 2020Review
- Review
- Differential asthma odds following respiratory infection in children from three minority populations.PloS one · 2020Article
- Aims, Study Design, and Enrollment Results From the Assessing Predictors of Infant Respiratory Syncytial Virus Effects and Severity Study.JMIR research protocols · 2019Article
- Host Components Contributing to Respiratory Syncytial Virus Pathogenesis.Frontiers in immunology · 2019Review
- Air pollutants and early origins of respiratory diseases.Chronic diseases and translational medicine · 2018Article
- CD38 modulates respiratory syncytial virus-driven proinflammatory processes in human monocyte-derived dendritic cells.Immunology · 2018Article
- American Thoracic Society/National Heart, Lung, and Blood Institute Asthma-Chronic Obstructive Pulmonary Disease Overlap Workshop Report.American journal of respiratory and critical care medicine · 2017Article
- The Burden and Long-term Respiratory Morbidity Associated with Respiratory Syncytial Virus Infection in Early Childhood.Infectious diseases and therapy · 2017Review
- Respiratory Syncytial Virus Infection: An Illness for All Ages.Clinics in chest medicine · 2017Review
- Recent advances in understanding lung function development.F1000Research · 2017Review
- A Distinct Low Lung Function Trajectory from Childhood to the Fourth Decade of Life.American journal of respiratory and critical care medicine · 2016Article
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Authors and funding
6 authors.
Funding
Abstract
rationaleRisk of subsequent asthma-like symptoms after early-life lower respiratory illness (LRI) caused by respiratory syncytial virus (RSV) is increased during the first decade of childhood and diminished thereafter by adolescence.
objectivesTo determine the relation of early-life RSV-LRI on adult asthma-like symptoms and its interactive role with adult smoking.
methodsA total of 1,246 nonselected infants were enrolled at birth and prospectively followed. Virologically confirmed RSV-LRIs were assessed during the first 3 years of life. At age 22, 24, 26, and 29 years, current asthma and smoking behavior were evaluated by questionnaire. Peak flow variability was assessed at age 26 and expressed as amplitude % mean. A longitudinal analysis was used to investigate the relation of RSV-LRI and active smoking to adult outcomes. MEASUREMENTS AND MAIN
resultsNeither RSV-LRI nor active smoking were directly associated with increased current adult asthma or peak flow variability. However, there was a significant interaction between RSV-LRI and active smoking in relation to current asthma (P for interaction = 0.004) and peak flow variability (P for interaction = 0.04). Among subjects with early RSV-LRI, those who actively smoked were 1.7 times more likely to have current asthma (95% confidence interval, 1.2-2.3; P = 0.003) and had greater amplitude % mean (10.0% vs. 6.4%; P = 0.02) than nonsmokers. Among subjects without early RSV-LRI, there was no difference in asthma risk or peak flow variability between active smokers and nonsmokers.
conclusionsSmoking is associated with increased risk of having asthma in young adults who had RSV-LRI in early life but not among subjects without these illnesses.
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