Evidence map›Paper›PMID 24927125›Full record

SynthesisPloS one2014

Diabetes mellitus and risk of thyroid cancer: a meta-analysis.

Yohwan Yeo, Seung-Hyun Ma, Yunji Hwang, Pamela L Horn-Ross, Ann Hsing, Kyu-Eun Lee, Young Joo Park, Do-Joon Park, Keun-Young Yoo, Sue K Park

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04298684 (Efficacy of Metformin Versus Sitagliptin on Benign Thyroid Nodules Size in Type 2 Diabetes), which is not on this map. Cited by 69 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 12 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04298684 phase4unknown statusstarted 2021, after this paper: background citation

Efficacy of Metformin Versus Sitagliptin on Benign Thyroid Nodules Size in Type 2 Diabetes: a 2-years Prospective Multicentric Study

Ran2021Enrolled90Registered outcomes9Posted comparisons0ConditionsDiabetes Mellitus, Type 2, Thyroid Nodule (Benign)ArmsMetformin, Sitagliptin
PMID 26154837PMID 27987248PMID 22232784PMID 28196954PMID 29158735PMID 29858981PMID 30233494PMID 3899825PMID 9839117PMID 2480830PMID 23395200PMID 22278418other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 12 syntheses or guidelines pooled it, 97 citations in OpenAlex.

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  7. Type 2 Diabetes and Cancer: An Umbrella Review of Observational and Mendelian Randomization Studies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
    Pooled it
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Yohwan YeoDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
Seung-Hyun MaDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea; Cancer Research Institute, Seoul National University, Seoul, Korea.
Yunji HwangCancer Research Institute, Seoul National University, Seoul, Korea; Department of Biomedical Science, Seoul National University Graduate School, Seoul, Korea.
Pamela L Horn-RossCancer Prevention Institute of California, Fremont, California, United States of America.
Ann HsingCancer Prevention Institute of California, Fremont, California, United States of America.
Kyu-Eun LeeDepartment of Surgery, Seoul National University College of Medicine, Seoul, Korea.
Young Joo ParkDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Do-Joon ParkDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Keun-Young YooDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
Sue K ParkDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea; Cancer Research Institute, Seoul National University, Seoul, Korea; Department of Biomedical Science, Seoul National University Graduate School, Seoul, Korea.
Seoul National University · KRCancer Prevention Institute of California · USCancer Research Institute · USNew Generation University College · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDiabetes mellitus (DM) is an important risk factor for endocrine cancers; however, the association with thyroid cancer is not clear. We performed a systematic review and meta-analysis to clarify the association between thyroid cancer and DM.

methodsWe searched MEDLINE, PUBMED and EMBASE databases through July 2012, using search terms related to diabetes mellitus, cancer, and thyroid cancer. We conducted a meta-analysis of the risk of incidence of thyroid cancer from pre-existing diabetes. Of 2,123 titles initially identified, sixteen articles met our inclusion criteria. An additional article was identified from a bibliography. Totally, 14 cohort and 3 case-control studies were selected for the meta-analysis. The risks were estimated using random-effects model and sensitivity test for the studies which reported risk estimates and used different definition of DM.

resultsCompared with individuals without DM, the patients with DM were at 1.34-fold higher risk for thyroid cancer (95% CI 1.11-1.63). However, there was heterogeneity in the results (p<0.0001). Sensitivity tests and studies judged to be high quality did not show heterogeneity and DM was associated with higher risk for thyroid cancer in these sub-analyses (both of RRs = 1.18, 95% CIs 1.08-1.28). DM was associated with a 1.38-fold increased risk of thyroid cancer in women (95% CI 1.13-1.67) after sensitivity test. Risk of thyroid cancer in men did not remain significant (RR 1.11, 95% CI 0.80-1.53).

conclusionsCompared with their non-diabetic counterparts, women with pre-existing DM have an increased risk of thyroid cancer.

Indexed as

Cohort StudiesDatabases, BibliographicDiabetes ComplicationsDiabetes MellitusFemaleHumansIncidenceMaleRisk FactorsSex FactorsThyroid Neoplasms

Identifiers

PMID24927125
PMCPMC4057085
OpenAlexW2054033780

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.