Evidence map›Paper›PMID 24927122›Full record

ArticlePloS one2014

Altered expression of hypoxia-inducible factor-1α (HIF-1α) and its regulatory genes in gastric cancer tissues.

Jihan Wang, Zhaohui Ni, Zipeng Duan, Guoqing Wang, Fan Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 60 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jihan WangDepartment of Pathogenobiology, Jilin Key Laboratory of Biomedical Materials, College of Basic Medical Science, Jilin University, Changchun, China.
Zhaohui NiDepartment of Pathogenobiology, Jilin Key Laboratory of Biomedical Materials, College of Basic Medical Science, Jilin University, Changchun, China.
Zipeng DuanDepartment of Pathogenobiology, Jilin Key Laboratory of Biomedical Materials, College of Basic Medical Science, Jilin University, Changchun, China.
Guoqing WangDepartment of Pathogenobiology, Jilin Key Laboratory of Biomedical Materials, College of Basic Medical Science, Jilin University, Changchun, China; The Key Laboratory for Bionics Engineering, Ministry of Education, China, Jilin University, Changchun, China.
Fan LiDepartment of Pathogenobiology, Jilin Key Laboratory of Biomedical Materials, College of Basic Medical Science, Jilin University, Changchun, China; The Key Laboratory for Bionics Engineering, Ministry of Education, China, Jilin University, Changchun, China.
Jilin Medical University · CNJilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tissue hypoxia induces reprogramming of cell metabolism and may result in normal cell transformation and cancer progression. Hypoxia-inducible factor 1-alpha (HIF-1α), the key transcription factor, plays an important role in gastric cancer development and progression. This study aimed to investigate the underlying regulatory signaling pathway in gastric cancer using gastric cancer tissue specimens. The integration of gene expression profile and transcriptional regulatory element database (TRED) was pursued to identify HIF-1α ↔ NFκB1 → BRCA1 → STAT3 ← STAT1 gene pathways and their regulated genes. The data showed that there were 82 differentially expressed genes that could be regulated by these five transcription factors in gastric cancer tissues and these genes formed 95 regulation modes, among which seven genes (MMP1, TIMP1, TLR2, FCGR3A, IRF1, FAS, and TFF3) were hub molecules that are regulated at least by two of these five transcription factors simultaneously and were associated with hypoxia, inflammation, and immune disorder. Real-Time PCR and western blot showed increasing of HIF-1α in mRNA and protein levels as well as TIMP1, TFF3 in mRNA levels in gastric cancer tissues. The data are the first study to demonstrate HIF-1α-regulated transcription factors and their corresponding network genes in gastric cancer. Further study with a larger sample size and more functional experiments is needed to confirm these data and then translate into clinical biomarker discovery and treatment strategy for gastric cancer.

Indexed as

Gene Expression Regulation, NeoplasticGenes, RegulatorHumansHypoxia-Inducible Factor 1, alpha SubunitInterferon Regulatory Factor-1Matrix Metalloproteinase 1PeptidesReceptors, IgGStomach NeoplasmsTissue Inhibitor of Metalloproteinase-1Toll-Like Receptor 2Trefoil Factor-3FCGR3A protein, humanHypoxia-Inducible Factor 1, alpha SubunitInterferon Regulatory Factor-1IRF1 protein, humanMatrix Metalloproteinase 1MMP1 protein, humanPeptidesReceptors, IgGTFF3 protein, humanTIMP1 protein, humanTissue Inhibitor of Metalloproteinase-1TLR2 protein, humanToll-Like Receptor 2Trefoil Factor-3

Identifiers

PMID24927122
PMCPMC4057318
OpenAlexW2110573224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.