ReviewEnvironmental health perspectives2014
Evaluating potential response-modifying factors for associations between ozone and health outcomes: a weight-of-evidence approach.
Review in Environmental health perspectives, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Geospatial indicators of exposure, sensitivity, and adaptive capacity to assess neighbourhood variation in vulnerability to climate change-related health hazards.Environmental health : a global access science source · 2021Pooled it
- A Systematic Review and Meta-Analysis of Short-Term Ambient Ozone Exposure and COPD Hospitalizations.International journal of environmental research and public health · 2020Pooled it
- Air pollution, cardiovascular endpoints and susceptibility by stress and material resources: a systematic review of the evidence.Environmental health : a global access science source · 2017Pooled it
- Climate and air pollution are associated with pediatric respiratory hospitalizations in São Paulo, Brazil.Frontiers in pediatrics · 2026Article
- Short-Term Effect of Ozone Exposure on Small Airway Function in Adult Asthma Patients with PMToxics · 2025Article
- Acute air pollution exposure and gastrointestinal cancer mortality: a case-crossover study in coastal China.Frontiers in public health · 2025Article
- Sociodemographic Determinants of Extreme Heat and Ozone Risk Among Older Adults in 3 Sun Belt Cities.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Current practice and recommendations for advancing how human variability and susceptibility are considered in chemical risk assessment.Environmental health : a global access science source · 2023Review
- Increased tropospheric ozone levels as a public health issue during COVID-19 lockdown and estimation the related pulmonary diseases.Atmospheric pollution research · 2022Article
- Confounding by Socioeconomic Status in Epidemiological Studies of Air Pollution and Health: Challenges and Opportunities.Environmental health perspectives · 2021Review
- Prenatal and Postnatal Cigarette Smoke Exposure Is Associated With Increased Risk of Exacerbated Allergic Airway Immune Responses: A Preclinical Mouse Model.Frontiers in immunology · 2021Article
- Air pollution and children's respiratory health: a scoping review of socioeconomic status as an effect modifier.International journal of public health · 2020Article
- Early life exposure to air pollution and incidence of childhood asthma, allergic rhinitis and eczema.The European respiratory journal · 2020Article
- Variability in ambient ozone and fine particle concentrations and population susceptibility among Canadian health regions.Canadian journal of public health = Revue canadienne de sante publique · 2019Article
- Modulation of the lung inflammatory response to ozone by the estrous cycle.Physiological reports · 2019Article
- Examining Joint Effects of Air Pollution Exposure and Social Determinants of Health in Defining "At-Risk" Populations Under the Clean Air Act: Susceptibility of Pregnant Women to Hypertensive Disorders of Pregnancy.World medical & health policy · 2018Article
- Leveraging human genetic and adverse outcome pathway (AOP) data to inform susceptibility in human health risk assessment.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Ozone Exposure, Cardiopulmonary Health, and Obesity: A Substantive Review.Chemical research in toxicology · 2017Review
- Ozone and childhood respiratory disease in three US cities: evaluation of effect measure modification by neighborhood socioeconomic status using a Bayesian hierarchical approach.Environmental health : a global access science source · 2017Article
- Ozone Inhalation Provokes Glucocorticoid-Dependent and -Independent Effects on Inflammatory and Metabolic Pathways.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpidemiologic and experimental studies have reported a variety of health effects in response to ozone (O3) exposure, and some have indicated that certain populations may be at increased or decreased risk of O3-related health effects.
objectivesWe sought to identify potential response-modifying factors to determine whether specific groups of the population or life stages are at increased or decreased risk of O3-related health effects using a weight-of-evidence approach.
methodsEpidemiologic, experimental, and exposure science studies of potential factors that may modify the relationship between O3 and health effects were identified in U.S. Environmental Protection Agency's 2013 Integrated Science Assessment for Ozone and Related Photochemical Oxidants. Scientific evidence from studies that examined factors that may influence risk were integrated across disciplines to evaluate consistency, coherence, and biological plausibility of effects. The factors identified were then classified using a weight-of-evidence approach to conclude whether a specific factor modified the response of a population or life stage, resulting in an increased or decreased risk of O3-related health effects. DISCUSSION: We found "adequate" evidence that populations with certain genotypes, preexisting asthma, or reduced intake of certain nutrients, as well as different life stages or outdoor workers, are at increased risk of O3-related health effects. In addition, we identified other factors (i.e., sex, socioeconomic status, and obesity) for which there was "suggestive" evidence that they may increase the risk of O3-related health effects.
conclusionsUsing a weight-of-evidence approach, we identified a diverse group of factors that should be considered when characterizing the overall risk of health effects associated with exposures to ambient O3.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.