ArticlePloS one2014
Correlation of intra-tumor 18F-FDG uptake heterogeneity indices with perfusion CT derived parameters in colorectal cancer.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Limits of radiomic-based entropy as a surrogate of tumor heterogeneity: ROI-area, acquisition protocol and tissue site exert substantial influence.Scientific reports · 2017Trial
- Tumour Microenvironment-Informed Radiotheranostics: Why and How Nuclear Medicine Could Advance Precision Oncology in the Decade Ahead.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Imaging of young-onset colorectal cancer: what the radiologist needs to know.Abdominal radiology (New York) · 2025Review
- Feasibility of different meningioma delineation approaches on [Discover oncology · 2025Article
- Intratumor heterogeneity: A new perspective on colorectal cancer research.Cancer medicine · 2020Review
- AI-based applications in hybrid imaging: how to build smart and truly multi-parametric decision models for radiomics.European journal of nuclear medicine and molecular imaging · 2019Review
- Noninvasive assessment and quantification of tumor vascularization using [18F]FDG-PET/CT and CE-CT in a tumor model with modifiable angiogenesis-an animal experimental prospective cohort study.EJNMMI research · 2019Article
- Comparison of radiomics machine-learning classifiers and feature selection for differentiation of sacral chordoma and sacral giant cell tumour based on 3D computed tomography features.European radiology · 2019Article
- Metabolic Imaging Phenotype Using Radiomics of [Molecular imaging and biology · 2019Article
- Robustness versus disease differentiation when varying parameter settings in radiomics features: application to nasopharyngeal PET/CT.European radiology · 2018Article
- Investigating multi-radiomic models for enhancing prediction power of cervical cancer treatment outcomes.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2018Article
- Reproducibility of F18-FDG PET radiomic features for different cervical tumor segmentation methods, gray-level discretization, and reconstruction algorithms.Journal of applied clinical medical physics · 2017Article
- A Novel Framework for Automated Segmentation and Labeling of Homogeneous Versus Heterogeneous Lung Tumors in [Molecular imaging and biology · 2017Article
- Prediction of Recurrence by Preoperative Intratumoral FDG Uptake Heterogeneity in Endometrioid Endometrial Cancer.Translational oncology · 2017Article
- Characterization of PET/CT images using texture analysis: the past, the present… any future?European journal of nuclear medicine and molecular imaging · 2017Review
- [European journal of hybrid imaging · 2017Article
- Value ofThe British journal of radiology · 2016Article
- Applications and limitations of radiomics.Physics in medicine and biology · 2016Review
- Development of a nomogram combining clinical staging with (18)F-FDG PET/CT image features in non-small-cell lung cancer stage I-III.European journal of nuclear medicine and molecular imaging · 2016Article
- A Study on the Basic Criteria for Selecting Heterogeneity Parameters of F18-FDG PET Images.PloS one · 2016Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
methodsThirty patients with proven colorectal cancer prospectively underwent integrated 18F-FDG PET/DCE-CT to assess the metabolic-flow phenotype. Both CT blood flow parametric maps and PET images were analyzed. Correlations between PET heterogeneity and perfusion CT were assessed by Spearman's rank correlation analysis.
resultsBlood flow visualization provided by DCE-CT images was significantly correlated with 18F-FDG PET metabolically active tumor volume as well as with uptake heterogeneity for patients with stage III/IV tumors (|ρ|:0.66 to 0.78; p-value<0.02).
conclusionThe positive correlation found with tumor blood flow indicates that intra-tumor heterogeneity of 18F-FDG PET accumulation reflects to some extent tracer distribution and consequently indicates that 18F-FDG PET intra-tumor heterogeneity may be associated with physiological processes such as tumor vascularization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.